20th IVBM
Helsinki, Finland
June 3-7, 2018
Abstracts due March 19!
Vasculata 2018
St. Louis, MO
July 23 - 26, 2018
Vascular Biology
Newport, RI
October 14-18, 2018
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Shop at Amazon?
Help Support NAVBO
Use this link to shop for everyone and everything
smile.amazon.com/ch/52-1917956 and Amazon will donate to NAVBO
First time? Great!!! You'll earn 1.5% for NAVBO from March 12-31!!
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Register for Today's Webinar with Ondine Cleaver
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Webinar Featuring Ondine Cleaver
There is still space available for today's 1:00pm EST webinar,
GTPase regulation of actomyosin during blood vessel tubulogenesis, by Ondine Cleaver, UT Southwestern Medical Center.
It's free for current NAVBO members!
To register go to:
http://www.navbo.org/events/webinars/665-webinar032018
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Next Webinar is April 5
- featuring Jessica Wagenseil of Washington University in St. Louis
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Register for Vascular Biology and Vasculata
Registration is now open for our annual meeting,
Vascular Biology (October 14-18 in Newport, RI). Go to
www.navbo.org/vb2018
You can also register now for
Vasculata 2018 (July 23-26, St. Louis, MO). Go to
www.navbo.org/vasculata.
Remember workshops fill up quickly, so register soon!
You can also
submit an abstract for either meeting. Go to the appropriate meeting web site.
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Abstract submission closes: March 19, 2018
Trainee Members Apply for a Travel Award
NAVBO is supporting more travel awards to this year's IVBM than for previous IVBMs held outside of North America - up to 8 awards valued at $1,200 each. Apply for an award at
http://www.navbo.org/awards/trainee-awards/ivbm-travel-awards
Award application deadline is also March 19!
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Vascular Calcification - Call for Papers
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NAVBO Research Topic on Vascular Calcification 
NAVBO has joined with Frontiers, publishers of
Frontiers In Cardiovascular Medicine,and co-editors
Dwight Towler, UT Southwestern Medical Center and
Yabing Chen, University of Alabama, to assemble a collection of papers in the research topic of Vascular Calcification.
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Don't Miss This Year's March For Science
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Stand United in Supporting Science
Did you know that the 2018 March for Science is just around the corner? As a partner of MFS, we are standing up for the common good by supporting evidence- and science-based policy on April 14, and we hope you will be a part of it.
Last year, more than one million people from around the world gathered to support science at the largest pro-science march in history. We want to continue to send our message of support.
Vote for Science Campaign
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The Lab of Dr. Stryder Meadows
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Who benefits from-and pays for-the work of creating an equitable and inclusive work environment?
Expecting graduate students to shoulder the burden of efforts that honor and celebrate diversity, benefiting the broader university community-without compensation or accountability-is by its nature exploitative, argues Prabhdeep Kehal, a doctoral student in sociology at Brown University. Writing in
Inside Higher Ed
, Kehal notes that "[t]hroughout my postsecondary career, much of my time has been dedicated to supporting diversity and inclusion initiatives. I volunteered this labor as if these institutions were entitled to my time. Very rarely was I asked to engage, because the assumption was that I would engage. After experiencing years of slow progress, I came to see more clearly an immense gap between an institution's intention for inclusion and their investment in it." The author's experience, and that of others cited, has left a sense of frustration alongside their commitment to the value of diversity and inclusion in the academy.
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Staying Ahead of the Game
 Greetings from New Orleans! My name is Stryder Meadows and I am an Assistant Professor at Tulane University. In 2014, I dove head first into the most challenging undertaking of my life. I uprooted my family and started my own research lab in a new state. Reflecting on the past 3 years, I would like to think I've had some professional successes while minimizing the hiccups along the way. I'm happy to have the opportunity to share my thoughts and opinions about my journey, and hope that my experiences prove useful to future independent investigators. We are all somewhat thrown into this position with no road map for establishing a thriving research program, so be proactive in seeking advice and stay ahead of the game.
Focus on the science: You already know this but it's important to keep in mind - science drives everything. So get in the lab and stay focused! If you're like myself, you will have a tendency to get interested and distracted by too many potential projects. Don't do this - work hard and place your energy on the most promising projects that will drive your lab. Make sure these projects differentiate yourself from your postdoc advisor. And don't be afraid to use your start up funds because you need the resources and man/woman power to build a solid body of work for that first big grant.
Getting funded: The obvious goal is to get big money grants, but don't forget about all those smaller grants out there, including those from your own institute. Take advantage of grants that are designed for new investigators. Acquiring these grants will look good on your resume, help with the research finances, and give you additional writing practice for your first big grant. In terms of the obtaining your first big grant, my advice is to hold off until you have a good, solid body of work. It takes time to build a story, and very few new investigators are going to get that big grant unless they've built a story, started publishing, etc. Be sure to have your mentors and colleagues look at your grants. A common mistake of a new investigator is to try and put too much into that first R01. Established investigators have been through this process many times and will know how to keep your grant focused.
continue reading . . .
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Welcome to our New Members:
Liana Boraas, Yale University
Emma Erlich, Washington University in St. Louis
Yu Hisano, Boston Children's Hospital
Umamah Tarvala, National Heart and Lung Institute
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Recent Publications by NAVBO Members
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| Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels
Pflugers Archiv - European Journal of Physiology
Following chronic hypoxia (CH), the systemic vasculature exhibits blunted vasoconstriction due to endothelial-dependent hyperpolarization (EDH). Read more Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca2+ entry
American Journal of Physiology Heart and Circulatory Physiology
Endothelial dysfunction in chronic hypoxia (CH)-induced pulmonary hypertension is characterized by reduced store-operated Ca2+ entry (SOCE) and diminished Ca2+-dependent production of endothelium-derived vasodilators. Read more RhoA increases ASIC1 plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia
American Journal of Physiology Cell Physiology
Increases in pulmonary arterial smooth muscle cell (PASMC) intracellular Ca2+ levels and enhanced RhoA/Rho kinase-dependent Ca2+ sensitization are key determinants of PASMC contraction, migration, and proliferation accompanying the development of hypoxic pulmonary hypertension. Read more Uptake of fatty acids by a single endothelial cell investigated by Raman spectroscopy supported by AFM
Analyst
In this work, confocal Raman imaging was used to study the formation of lipid droplets (LDs) in vitro in a single endothelial cell upon incubation with polyunsaturated fatty acids (10 or 25 µM) including arachidonic acid (AA) and its deuterated analog (AA-d8), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Read more Robust oil-core nanocapsules with hyaluronate-based shells as promising nanovehicles for lipophilic compounds
Nanoscale
The design of nanodelivery systems has been recently considered as a solution to the major challenge in pharmaceutical research - poor bioavailability of lipophilic drugs. Read more Endothelial immune activation programs cell-fate decisions and angiogenesis by inducing DLL4 through TLR4-ERK-FOXC2 signalling
The Journal of Physiology
Endothelial cells (EC) mediate a specific and robust immune response to bacteria in sepsis through the activation of Toll-Like Receptor (TLR) signalling. Read more Molecular Regulation of Sprouting Angiogenesis
Comprehensive Physiology
The term angiogenesis arose in the 18th century. Several studies over the next 100 years laid the groundwork for initial studies performed by the Folkman laboratory, which were at first met with some opposition. Read more Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1
Circulation
BACKGROUND: Arterial stiffness and wall shear stress are powerful determinants of cardiovascular health, and arterial stiffness is associated with increased cardiovascular mortality. Read more |
Experimental Reproducibility in Crisis
There is a reproducibility crisis occurring in the life sciences that impacts all researchers, influencing the collection, analysis, and interpretation of their data. Recent surveys have shown that more than half of researchers struggle to reproduce not only the results of their fellow scientists, but their own experimental data as well. To help scientists wrestle with this thorny issue, Science magazine is hosting a webinar on Wednesday March 14, 2018. Viewers will learn how irreproducible or questionable data can result in time-consuming, costly repetition of studies and, in some cases, misinterpreted or incorrect conclusions. Participants include John Ioannidis, M.D., D.Sc., from Stanford University and Gregor Witte, Ph.D., from Ludwig Maximillian Universität in Munich.
Updated Parent Program Announcements for NIH Fellowships Released
Welcome tidings for pre- and post-doctoral trainees in search of fellowship support: the NIH has issued 2018 program announcements for their family of Ruth L. Kirschstein National Research Service Awards (NRSAs). Opportunities include sponsorship for Individual
Predoctoral Fellows to Promote Diversity in Health-Related Research (F31), Individual Fellowships for Students at Institutions with NIH-Funded Institutional
Predoctoral Dual-Degree Training Programs (F30),
Individual Postdoctoral Fellowships (F32), and
Individual Predoctoral Fellowships (F31). This family of programs is long-standing, and its components have been reliably re-issued at 2-3 year intervals; nevertheless, it is reassuring for trainees-and their mentors-to see the current crop emerge.
Speaking of NIH funding...it translates!
From STAT
A study recently published in PNAS by researchers at Bentley University documents the importance of federal support for basic research: NIH-funded studies contributed to the science that underlies every one of the 210 new drugs approved by the FDA between 2010 and 2016. The study, led by Dr. Fred Ledley of Bentley's Center for Integration of Science and Industry, is novel in its examination of the links, both direct and indirect, between NIH sponsorship and the advent of FDA-approved drugs. The authors conclude with a strong case for continued federal funding of basic science - which some view as under threat by the current administration. Of the 210 approved agents, 84 were considered "first-in-class," that is, treating disease through novel mechanisms or molecular targets.
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