June 28, 2018

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Vasculata 2018 
St. Louis, MO
July 23 - 26, 2018
Supported in part by the:  

Vascular Biology 
Newport, RI 
October 14-18, 2018 

Lymphatic Forum 2019
Austin, TX
May 31 - June 1, 2019
Next webinar is June 14
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Vascular Biology 2018 - October 14-18 in Newport!
New Venue for Vascular Biology

Vascular Biology 2018 will feature the Vascular Inflammation Workshop and the Biology of Signaling in the Cardiovascular System Workshop.  Our new venue, in Newport, RI, is Gurney's Newport Resort and Marina located on Goat Island.  Just a 10 minute walk from downtown Newport!

Plan now to attend!  Go to www.navbo.org/vb2018 for the meeting program, registration, abstract submission, award applications and more!
Attend Vasculata 2018 in St. Louis
Plan to attend Vasculata this summer July 23-26 in St. Louis

Next NAVBO Webinar
Sign up now for our August 2 Webinar with Michael Dellinger 

Our webinar attendees requested a webinar on Lymphatics, so please join us on August 2 at 1:00pm EDT for Dr. Dellinger's presentation, "Lymphatic Vessels and Vanishing Bones: Animal Models of Lymphatic Anomalies with Bone Involvement."  Dr. Dellinger is an Assistant Professor at UT Southwestern Medical Center. 

The webinar is sponsored by the Lymphatic Malformation Institute and the Lymphangomatosis & Gorham's Disease Alliance.

To register for the webinar please go to   http://www.navbo.org/events/webinars/718-webinar082018 

Please note: we will not be holding a July webinar  
Registration for Vasculata closes on July 20
Early bird registration ends:
Vascular Biology 2018 - August 15
Abstract Submission Deadline:
Vascular Biology 2018 - August 1
Nominate a colleague for a Meritorious Award: 
Nominations for the 2019 Earl P. Benditt Award and the Judah Folkman Award in Vascular Biology are due July 8.

NAVBO Travel Awards are available for the following meetings:
World Congress on Microcirculation - go to http://www.navbo.org/awards/trainee-awards/wcm2018 for information.  The deadline is July 5.

Vascular Biology 2018 - submit an abstract and apply for a trainee travel award at http://www.navbo.org/awards/trainee-awards  by  August 1
Bioinformatics at Vascular Biology 2018!!!
Watch the webinar and see how bioinformatics can enhance your research (click on the slide to start the movie)

Attend Vascular Biology 2018 and register for this special session!
Bring your lap top and you favorite gene!!
Spotlight on Trainees
Applications solicited for Science and SciLifeLab's Prize for Young Scientists
For the sixth year, Science/AAAS and SciLifeLab, a coordinated effort of four universities, have joined forces to recognize outstanding recent doctoral graduates in the life sciences (Ph.D. awarded between January 1, 2016, and December 31, 2017).  This award, intended to provide encouragement to young scientists beginning their scientific careers, includes a grand prize of $30,000, as well as $10,000 to winners in each of three other subject categories (Cell and Molecular Biology; Genomics and Proteomics; Ecology and Environment; Translational Medicine).  Applications are due July 15, 2018.  Winners will have their essays prominently published and will be honored in Stockholm, Sweden, in December of this year. 

(from the July 14 issue)
When it comes to workplace challenges, there's nothing new under the sun "Congrats, 1971 Stanford grad! You're full of energy, enthusiasm-and naivet√©."  So begins an imagined letter to Joann Lublin's younger self,
published recently in The Wall Street Journal.   Lublin, by now a veteran editor for the WSJ, has some hard-earned pointers on negotiating numerous workplace issues, including unbridled gender bias and unevenly applied corporate policies.  Although Lublin has pursued a profession somewhat afield from medical research, there is an abundance of wisdom in her reflections that is well worth the attention of eager trainees approaching their first independent positions. 
Lab of the Month
The Lab of Dr. C. Keith Ozaki
This month we are highlighting the lab of Dr. C. Keith Ozaki, a Professor in the Division of Vascular and Endovascular Surgery, at Brigham and Women's Hospital/Harvard Medical School. Find out more about Dr. Ozaki and his lab at http://www.navbo.org/membership/members-labs/720-lab062018
Member News
Welcome to our New Members:
Timothy Sargis, University of Illinois at Chicago
Scott Wong, Boston Children's Hospital

If you have news to share with your colleagues, send it to membership@navbo.org.
 Recent Publications by NAVBO Members

CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis
Background: Valvular heart disease is common and affects the mitral valve (MV) most frequently. Despite the prevalence of MV disease (MVD), the cellular and molecular pathways that initiate and perpetuate it are not well understood.  Read more 


Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence
Cell Reports
Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction.  Read more 


Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury
Cell Death Discovery
Vascular endothelial cadherin (VE-cad) expression at endothelial adherens junctions (AJs) regulates vascular homeostasis.  Read more 


Clinical factors that influence the cellular responses of saphenous veins used for arterial bypass
Journal of Vascular Surgery
OBJECTIVE: When an autogenous vein is harvested and used for arterial bypass, it suffers physical and biologic injuries that may set in motion the cellular processes that lead to wall thickening, fibrosis, stenosis, and ultimately graft failure.  Read more 


Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells
Background -The progression toward low-cost and rapid next-generation sequencing has uncovered a multitude of variants of uncertain significance (VUS) in both patients and asymptomatic "healthy" individuals.  Read more 


Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models
Advanced Drug Delivery Reviews
In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology.  Read more 


EMAPII Monoclonal Antibody Ameliorates Influenza A Virus-Induced Lung Injury
Molecular Therapy

Influenza A virus (IAV) remains a major worldwide health threat, especially to high-risk populations, including the young and elderly. There is an unmet clinical need for therapy that will protect the lungs from damage caused by lower respiratory infection. Here, the authors analyzed the role of EMAPII, a stress- and virus-induced pro-inflammatory and pro-apoptotic factor, in IAV-induced lung injury.  Read more 
Industry News (from June 14 issue)
New hypertension guidelines explored in leading AHA journal 
The America Heart Association journal Hypertension has published a "New Perspectives" series of articles in June 2018 issue, examining the science behind and rationale for formulating the "Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults," released in 2017.  The new recommendations will likely change the way high blood pressure is evaluated and managed.  Actions by the AHA and collaborating professional groups reflects priorities set in the 2011 'Million Hearts' initiative, which articulated a goal of preventing a million heart attacks and strokes over the ensuing five years in the US.

Task force calls for increased inclusion of pregnant and lactating women in clinical studies A task force, charged by the US Department of Health and Human Services with identifying gaps in research on pregnant or lactating women, has finalized its work, calling for increased inclusion and integration of women from these groups into clinical trials.  As reported by MedPage Today, the study collective, named PRGLAC (Research Specific to Pregnant Women and Lactating Women), approved 15 recommendations, including the removal of pregnant women as a vulnerable population in the common rule, and the inclusion of pregnant women and lactating women to capture and report maternal, obstetric, and neonatal outcomes, including pregnancy complications such as pre-eclampsia.  Panelists from multiple government agencies (NIH, NICHD, FDA, and the National Vaccine Program Office) as well as members of industry and various professional organizations participated on the task force's efforts.
Annoyance in response to noise linked to dangerous cardiovascular ourcomes
A new report published in the International Journal of Cardiology explores the relationship between environmental noise and the genesis of cardiac arrhythmias.  Already studied in vascular disease, the new findings link responses to experiencing extreme aural stimulation (e.g., noise from aircraft, road, rail, and one's neighborhood) to increased incidence of atrial fibrillation.  Atrial fibrillation, the most common type of arrhythmia, can lead to thrombosis, stroke, and heart failure. Nearly three million Americans are affected by atrial fibrillation.  Noise annoyance, defined as noise-provoked responses such as anger, sleep disruption and subsequent exhaustion, and stress.  Study participants distinguished between noise annoyances during the day and at night and recorded their responses using standardized questionnaires.  Mechanisms connecting the noise annoyance responses and cardiac dysfunction remain to be defined. 
Job Postings
Calendar of Events
July 14 - 15, 2018
Endothelial Cell Phenotypes in Health and Disease (GRS)
July 15 - 20, 2018
Endothelial Cell Phenotypes in Health and Disease (GRC)
July 16 - 17, 2018
9th Edition of International Conference on Preventive Medicine & Public Health
July 18 - 21, 2018
ISTH SSC 2018 Meeting
Aug. 5 - 11, 2018
13th User Training Workshop Developing Multi-Scale, Virtual Simulations with CompuCell3D
Sept. 9 - 13, 2018
11th World Congress of Microcirculation (WCM2018)
Sept. 16 - 19, 2018
ISACB 2018 - 16th Biennial Meeting
Sept. 22 - 25, 2018
10th Kloster Seeon Meeting Angiogenesis
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
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Germantown, MD 20874-2211