September 29, 2016 
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NAVBO members receive discounts on registration to IVBM 2016
Look inside the IVBM Virtual Conference Bag

Lymphatic Forum
in Chicago, IL
June 8-10, 2017

Vascular Biology 2017
Monterey, CA
October 15-19 
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Meet the Professor Breakfasts Supported by

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Academic Supporters

Congratulations Stefania Nicoli - 2016 Springer Awardee
The NAVBO Meritorious Awards Committee and NAVBO Council are pleased to announce that Stefania Nicoli, Ph.D. , is the recipient of the 2016 Springer Junior Investigator Award, for which vascular biologists within five years of their first independent investigator position are eligible. Dr. Nicoli currently holds an appointments as Assistant Professor in Cardiology and Pharmacology at Yale University. Her work focuses on elucidating the role of miRNAs in vascular development and morphology, using a genome-editing approach targeting single and multi-gene miRNA families expressed in developing vascular cells in zebrafish. Please join us at the IVBM to hear Dr. Nicoli's Springer Award lecture at 10:45 AM on Thursday, November 3, 2016. Congratulations, Dr. Nicoli!
One Month to the IVBM!!!
19th International Vascular Biology Meeting 
Boston - October 30-November 3
Register online through October 28
(onsite registration will be available, late fee of $50 will apply)

Make your reservations at the Sheraton by October 8 to secure the group rate of $275 a night (single or double occupancy) for IVBM attendees (triple  is $315, quad is $355). This group rate is only available through October 8. To make your reservations online, go to: 

Additional information about child care, traveling around Boston, and additional offsite rooms at the Midtown Hotel can be found here:
Lessons Learned
Remember why you are doing science
By Daniela Simona Ardelean, University of Western Ontario

Do you remember the day when you thought that science is really cool and that this is what you want to do, no matter what? For some, it was a defined moment; for others, a longer, slow process. Some people could explain it, others just knew it. But for all, the knowledge or feeling (yes, it can be either one) that doing science is the right thing, was the same. You just knew. Remember that when you come across challenges that may seem insurmountable.

I am a pediatric rheumatologist who is doing translational research. Since I have started one year ago as a junior faculty at the Schulich School of Medicine and Dentistry at University of Western Ontario in London, Ontario, Canada, I have been working towards establishing my lab and building the team. This is still work in progress.

The transition from trainee to faculty is often lengthy and difficult. On this journey, I have learned a few things that I would like to share with you:

Think early about your research program.
Beyond research projects, you also need to discuss about your research program with your future collaborators, mentors and funding agencies.

What is your long-term goal? What is your vision? What do you need to get you there? It is important to define it early.
Connect with peers and scientists outside your discipline. To broaden your knowledge and to find collaborators and potential mentors, it is important to attend meetings, seminars, workshops, etc., in other disciplines.

Find out what funding opportunities are available at your institution(s).
The University, affiliated Research Institutes, the Department(s) where you are appointed or cross-appointed, hospital Foundations, etc., may have their own funding and internal competitions. Find out early about these opportunities and apply to them.

We need time for reflection. We are all busy people. However, without time put aside regularly for reflection, for thinking things through and for a break, it is difficult to come up with that great idea that is worth pursuing, be creative, have balance in life, and evolve as a human being.

Writing is about telling stories that matter to you and others.
There was something that motivated you in the first place to look for answers when there were very few or none. Findings how things work, deciphering the mechanisms of a process or disease, discovering new treatments for your patients. Conveying that "something" in writing increases the chance that your grant application or paper will connect with those that read it.
Despite the long path, challenges, ups and downs, we are privileged to do research. Remember why you chose science and make the most of your journey.
Member News
Vein Graft Symposium
This free meeting, organized by NAVBO members, Masanori Aikawa and C. Keith Ozaki, is taking place October 28 at Brigham and Women's Hospital, Boston.  If you are interested in attending or would like more information, click here .
Welcome our new members:
Takaomi Adachi, Yale University School of Medicine
Marco Haertle, Hannover Medical School
Sabah Hussain, McGill University
Princess Imoukhuede, University of Illinois at Urbana-Champaign
Fatma Kok, University of Massachusetts Medical School
Fabiola Munarin, Brown University
Mariana Osako, University of Sao Paulo
Tirthadipa Pradhan, University of Pittsburgh
Pierre-Louis Tharaux, INSERM
Jan Vitecek, St. Anne's University Hospital Brno
Liya Yin, Northeast Ohio Medical University

If you have news to share with your colleagues, send it to [email protected].
Spotlight on Trainees (from Sept 1 issue)
The halcyon days of a post-doc
Hard on the heels of   National PostDoc Appreciation Week , Science magazine has published a set of anecdotes from current post-docs, as well as scientists who have recently made the jump to their first faculty appointments. These vignettes offer tips for career advancement and the occasional bit of 20-20 hindsight regarding surprises encountered and road-not-taken choices that may have paid off. As is often the case in this era of online discourse, the comments appended to the article are equally enlightening, providing some balance to the success stories.

 Recent Publications by NAVBO Members

Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages
Journal of Visualized Experiments
A protocol is presented for cell culture of macrophage colony-stimulating factor (M-CSF) differentiated human monocyte-derived macrophages. For initiation of experiments, fresh or frozen monocytes are cultured in flasks for 1 week with M-CSF to induce their differentiation into macrophages.  Read more


Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior
Frontiers in Cell and Developmental Biology
Vascular endothelial growth factor A (VEGF) is involved in all the essential biology of endothelial cells, from proliferation to vessel function, by mediating intercellular interactions and monolayer integrity. It is expressed as three major alternative spliced variants.  Read more


Compartment syndrome causes systemic inflammation in a rat
The Bone and Joint Journal
AIMS: Compartment syndrome results from increased intra-compartmental pressure (ICP) causing local tissue ischaemia and cell death, but the systemic effects are not well described. We hypothesised that compartment syndrome would have a profound effect not only on the affected limb, but also on remote organs.  Read more


Endothelial glycocalyx, apoptosis and inflammation in an atherosclerotic mouse model
BACKGROUND AND AIMS: Previous experiments suggest that both increased endothelial cell apoptosis and endothelial surface glycocalyx shedding could play a role in the endothelial dysfunction and inflammation of athero-prone regions of the vasculature. We sought to elucidate the possibly synergistic mechanisms by which endothelial cell apoptosis and glycocalyx shedding promote atherogenesis.  Read more


Heparan sulfate proteoglycans mediate renal carcinoma metastasis
International Journal of Cancer
The surface proteoglycan/glycoprotein layer (glycocalyx) on tumor cells has been associated with cellular functions that can potentially enable invasion and metastasis. In addition, aggressive tumor cells with high metastatic potential have enhanced invasion rates in response to interstitial flow stimuli in vitro.  Read more


In vivo mutagenesis of miRNA gene families using a scalable multiplexed CRISPR/Cas9 nuclease system
Scientific Reports
A large number of microRNAs (miRNAs) are grouped into families derived from the same phylogenetic ancestors. miRNAs within a family often share the same physiological functions despite differences in their primary sequences, secondary structures, or chromosomal locations.  Read more


Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112: Effects on Cholesterol Efflux, Anti-Inflammatory and Antioxidative Activity
Circulation Research
RATIONALE: CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL).  Read more


Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension
Respiratory Research
BACKGROUND: Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans.  Read more


Retrospectively gated MRI for in vivo assessment of endothelium-dependent vasodilatation and endothelial permeability in murine models of endothelial dysfunction
NMR in Biomedicine
Endothelial dysfunction is linked to impaired endothelial-dependent vasodilatation and permeability changes. Here, we quantify both of these phenomena associated with endothelial dysfunction by MRI in vivo in mice. Endothelial function was evaluated in the brachiocephalic artery (BCA) and left carotid artery (LCA) in ApoE/LDLR(-/-) and high-fat diet (HFD)-fed mice as compared with control mice (C57BL/6J).  Read more

Plan to Attend - Exhibitor Showcases at the IVBM
Exhibitor Showcases at the IVBM - Boston

Monday, October 31 from 5:15-6:15pm
Protocols for Measuring Endothelial Barrier Function with ECIS
(from TEER across transwell filters to large scale screens on 96 well plates)
Presentation by Dr. Christian Renken, Applied BioPhysics

Wednesday, November 2 from 4:00-5:00pm

Monday, October 31 from 4:00-5:00pm
Targeted proteomics performed on the Q Exactive permits to study the metabolism of circulating apolipoproteins
Sasha A. Singh, Director of Proteomics Center for Interdisciplinary Cardiovascular Sciences Brigham and Women's Hospital, Boston, MA
Translational Proteomics Workflows for Extending the Profiling Range of Plasma/Serum
Scott Peterman and David Sarracino Thermo Fisher Scientific BRIMS, Cambridge, MA
Tuesday, November 1 from 4:00-5:00pm 
Unlocking Translational Biomarkers in Vascular Biology with Ultra High Frequency Ultrasound 
Presentation by Dr. Julius Decano, Brigham and Women's Hospital 

Industry News
Lasker Prizes awarded for research on mechanisms of response to hypoxia
William Kaelin (Harvard Medical School), Peter Ratcliffe (University of Oxford) and Gregg Semenza (Johns Hopkins) have been named recipients of the 2016 Albert Lasker Basic Medical Research Awards , in recognition of their "...discovery of the pathway by which cells from humans and most animals sense and adapt to changes in oxygen availability - a process essential for survival." The importance of hypoxia-inducible factors, key components of the pathways characterized by the awardees, is well known to investigators of angiogenesis, erythropoiesis, and energy metabolism. Congratulations and well-deserved, Drs. Kaelin, Ratcliffe, and Semenza!
Bioengineered tissue patches for cardiac repair
A new grant from the National Heart, Lung, and Blood Institute will support researchers at the University of Alabama-Birmingham, the University of Wisconsin-Madison, and Duke University in their effort to develop tissue engineered patches that can be applied to repair of infarcted cardiac muscle. This grant is part of the second round of the Progenitor Cell Translational Consortium U01 funding, whose objective is to promote cooperative research agreements among institutions to develop cell therapies for the heart, lung and blood.
David C. Goff, Jr., named Director of the NHLBI Division of Cardiovascular Sciences
NHLBI Director Gary Gibbons has announced the appointment of distinguished cardiovascular epidemiologist David C. Goff, Jr., M.D., Ph.D., as the  next Director of the Institute's Division of Cardiovascular Sciences , effective November 28, 2016. Dr. Goff comes to the NIH from the Colorado School of Public Health, where he has served as Dean since 2012. Prior to that, he was Chair of the Department of Epidemiology and Prevention in the Division of Public Health Sciences at Wake Forest University School of Medicine. In addition to his work as an investigator in academe, Dr. Goff has provided scientific direction for critical efforts across NIH, including membership on NHLBI Guideline Executive Group and as Co-Chair of the NHLBI Risk Assessment Working Group.
Job Postings
Job Title
Stanford University
Palo Alto, CA
Acute Care Nurse Practitioner
University of Virginia Health System
Charlottesville, VA
University of Pittsburgh
Pittsburgh, PA
Assistant Professor
Thomas Jefferson University
Philadelphia, PA
Calendar of Events
Oct. 28 Brigham and Women's Hospital Vein Graft Symposium
Oct. 30 - Nov. 3 19th International Vascular Biology Meeting
Nov. 13-16 American Society for Matrix Biology Biennial Meeting
June 8 - 10 Lymphatic Forum 2017
Oct. 15-19 Vascular Biology 2017
Collaborating Societies at the IVBM

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North American Vascular Biology Organization | [email protected] |
18501 Kingshill Road
Germantown, MD 20874-2211