March 17, 2016 
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Get Involved in NAVBO
Vasculata at YOUR Institution
The summer course on vascular biology has been presented at several different institutions including UCLA, Dartmouth, University of Washington, Cleveland Clinic, University of Virginia, University of California, San Diego, University of North Carolina, Chapel Hill, Vanderbilt University and Georgia Tech. The diversity in the settings keeps the course fresh as each institution highlights their own strengths.  Please consider hosting Vasculata at your institution.  Read more . . .

Consider running for NAVBO Council
If you are interested in getting more involved with NAVBO, consider running for election on the NAVBO Council. Every year two new Councilors are added and we are seeking volunteers.   Complete an application form . . .

Propose a session for Vascular Biology 2017
We're looking ahead to Vascular Biology 2017 (October 15-19 at the Asilomar Conference Grounds) and we want your input. The NAVBO Council and the meeting organizers (Vicki Bautch, Brian Black, Craig Simmons and Jessica Wagenseil) are seeking proposals from NAVBO members for a new session. This new session may or may not be directly related to the workshop themes. In 2017, we will present the Developmental Vascular Biology and Genetics Workshop and the Vascular Matrix Biology and Bioengineering Workshop. Our goal is to broaden the scope of our meetings, enhance the member experience and respond to our members' interests. To submit your proposal complete this pdf form and email it to Submissions are due May 1, 2016.
Vasculata 2016
August 15-18, 2016

In 2016, we will present the first European Vascu
lata, based in Uppsala, with live web cast to Philadelphia. There will be registration for both sites. The abstract submission sites are now open!  See

19th International Vascular Biology Meeting
Abstracts are already being submitted.  Don't delay - the abstract deadline is July 26, 2016.  And to save money - register by August 15.  Go to

Lymphatic Conference in Chicago 2017
June 8-11, 2017
Northwestern University

Vascular Biology 2017
Save the date 
October 15-19, 2017
Asilomar Conference Grounds, Monterey, CA

Vascular Biology, NAVBO's annual meeting, will feature the seventh presentation of the Developmental Vascular Biology and Genetics Workshop and the sixth presentation of the Matrix Biology and Bioengineering Workshop.
Lab of the Month
The Lab of Dr. David Dichek
This month we are highlighting the lab of Dr. David A. Dichek of the University of Washington in Seattle, Washington. Find out more about Dr. Dichek's lab at
View all featured laboratories at
Member News
Blood-brain barrier 
An interview  with Costantino Iadecola, MD, of Cornell's Brain and Mind Research Institute published by MedPage Today highlights possible links between vascular endothelial damage and the development of Alzheimer's disease. Dr. Iadecola notes that amyloid beta can activate NADPH oxidase via interaction with CD36 in the cerebral vascular wall, inducing free radical damage in endothelial vascular cells. Vascular amyloid can circulate in the blood, forming plaques associated with cerebral amyloid angiopathy.

Dr. Iadecola will give a presentation at the 19th International Vascular Biology Meeting entitled, "Neurovascular dysfunction and cognitive impairment," in the session on Neurovascular Disease in the Diseases Theme of the meeting. His talk is scheduled for Tuesday, November 1. 
Spotlight on Trainees
Biomedical research: Statistically stranger than fiction?
From the publisher of Raw Data - A Novel on Life in Science: "Chloe and Karen are ambitious and independent-minded young scientists, both trying to make their mark in the competitive world of biomedical science. They work in Tom Palmer's lab at a top-tier research institute in the US. Life in the lab is full of excitement and passion, but also frustrations, jealousy and the fear of being scooped. When honesty and scientific integrity are questioned in the context of a paper accepted at a prestigious journal, all are deeply affected and everyone must decide what actions to take to save their careers."
 Recent Publications by NAVBO Members

Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress
American Journal of Physiology-Cell Physiology
Shear stress is known to stimulate an intracellular free calcium concentration ([Ca2+]i) response in vascular endothelial cells (ECs). [Ca2+]i is a key second messenger for signaling that leads to vasodilation and EC survival. Although it is accepted that the shear-induced [Ca2+]i response is, in part, due to Ca2+ release from the endoplasmic reticulum (ER), the role of mitochondria (second largest Ca2+ store) is unknown.  Read more

Recent insights into endothelial control of leukocyte extravasation
Cellular and Molecular Life Sciences
In the process of leukocyte migration from the circulation across the vascular wall, the crosstalk with endothelial cells that line the blood vessels is essential. It is now firmly established that in endothelial cells important signaling events are initiated upon leukocyte adhesion that impinge on the regulation of cell-cell contact and control the efficiency of transendothelial migration.  Read more

Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration
Nutrition, Metabolism and Cardiovascular Diseases
Studies suggest that Gentiana lutea (GL), and its component isovitexin, may exhibit anti-atherosclerotic properties. In this study we sought to investigate the protective mechanism of GL aqueous root extract and isovitexin on endothelial inflammation, smooth muscle cell migation, and on the onset and progression of atherosclerosis in streptozotocin (STZ)-induced diabetic rats.  Read more

Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis
Journal of Experimental Medicine
The aorta is the largest artery in the body, yet processes underlying aortic pathology are poorly understood. The arterial media consists of circumferential layers of elastic lamellae and smooth muscle cells (SMCs), and many arterial diseases are characterized by defective lamellae and excess SMCs; however, a mechanism linking these pathological features is lacking.  Read more

Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis
Scientific Reports
We aimed to develop a quantitative antibody-based near infrared fluorescence (NIRF) approach for the imaging of oxidized LDL in atherosclerosis. LO1, a well- characterized monoclonal autoantibody that reacts with malondialdehyde-conjugated LDL, was labeled with a NIRF dye to yield LO1-750.  Read more

Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice
Journal of Clinical Investigation
Prox1 heterozygous mice have a defective lymphatic vasculature and develop late-onset obesity. Chyle abnormally leaks from those vessels, accumulates in the surrounding tissues, and causes an increase in adipose tissue. We characterized the lymphatics of Prox1+/- mice to determine whether the extent of obesity correlated with the severity of lymphatic defects.  Read more

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1
Cell Death and Differentiation
Angiogenesis is essential to match the size of blood vessel networks to the metabolic demands of growing tissues. While many genes and pathways necessary for regulating angiogenesis have been identified, those responsible for endothelial cell (EC) survival during angiogenesis remain largely unknown.  Read more

NRP1 function and targeting in neurovascular development and eye disease
Progress in Retinal and Eye Research
Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function.  Read more

Job Postings
Job Title
Columbia University
New York, NY
Assistant/Associate/Full Professor (Tenure Track)
University of Maryland - Baltimore
Baltimore, MD
Alpert Medical School at Brown and VA Providence
Providence, RI
Postdoctoral Fellow
San Francisco, CA
University of Oklahoma Health Sciences Center
Oklahoma City, OK
Research Associate
University of Toronto
Toronto, ON
University of Rochester Medical Center
Rochester, NY
Calendar of Events
Date Event
April 2-6
May 2-3
11th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease
May 25-28
ISTH 62nd Annual Scientific and Standardization Committee Meeting
July 17-22 Endothelial Cell Phenotypes in Health and Disease
Sept. 7-10 ISACB - 15th Biennial Meeting
Nov. 13-16
Industry News
Athletic heartache leads to marketing bonanza
The Washington Post reports  that sales of mildronate, the inhibitor of carnitine biosynthesis whose detection resulted in the recent suspension of tennis star Maria Sharapova, have jumped sharply in Russia. Mildronate, touted by its Latvian manufacturer Grindeks as able to improve memory, quicken thinking, and increase agility, is used in some eastern European countries to treat angina and the consequences of myocardial infarction. The FDA has not approved its use in the US, and experts question  the likelihood that it can improve cardiovascular performance in healthy athletes.

Yoga mellows atrial fibrillation
Research published this month from the Karolinska Institute in Stockholm indicates that certain forms of yoga can improve measures of quality of life and lower blood pressure and heart rate in patients with paroxysmal atrial fibrillation. Although study sample size was small, the investigators suggest that yoga with light movements and deep breathing could be an effective complement to standard therapy.

Ca2+ oscillations indicate VEGFR-mediated angiogenic capacity in vivo
A study published in eLife reports visualization of Ca2+ flux in zebrafish endothelial cells displaying angiogenic behavior. Ca2+ oscillations depended upon VEGF receptor-2 and -3 in endothelial cells budding from the dorsal aorta and posterior cardinal vein, respectively. In the dorsal aorta, VEGFR-dependent Ca2+ oscillations were evident in both migrating tip cells and stalk cells and required intact Dll4/Notch signaling.
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Germantown, MD 20874-2211