January 19, 2017
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Lymphatic Forum
in Chicago, IL
June 8-10, 20 17

Vasculata 2017
Chicago, IL 
July 24-27, 2017
(new dates!) 

Vascular Biology 2017
Monter ey, CA  
October 15-19

IVBM 2018
Helsinki, Finland
June 3-7 
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Plan Now for . . .
NAVBO is sponsoring or co-sponsoring three exciting meetings this year:

June 8-10 - Lymphatic Forum 2017 at Northwestern University

July 24-27 - Vasculata 2017 at the University of Illinois, Chicago

October 15-19 - Vascular Biology 2017 in Monterey, CA

Plan to attend at least one! 
Registration for the Lymphatics Forum is open, other sites will open by February 1.
Lab of the Month
The Lab of Dr. Diane Bielenberg
This month we are highlighting the lab of Dr. Diane Bielenberg, who is an Assistant Professor in the Department of Surgery, Harvard Medical School and in the Vascular Biology Program, Boston Children's Hospital. Find out more about Dr. Bielenberg's lab at http://www.navbo.org/membership/members-labs/555-lab122016.
Spotlight on Trainees ( from the January 5 issue)
Whither after the postdoc?
Maggie Kuo of Science Careers has posted brief accounts of the careers paths taken by five newly-minted postdocs, representing a variety of choices leading away from the research laboratory.  Recognizing that there are many more Ph.D. holders than available tenure-track faculty positions, trainees often find themselves considering major career shifts.  These five former postdocs now working in careers outside of research describe how they used their postdoc time to discern their strengths and career aspirations and to build the requisite skills and connections needed to secure rewarding non-research positions.
Member News
Welcome to our New Members:
Zoe Ashley, University of Otago
Maike Frye, Uppsala University
Jordan Yaron, Arizona State University
 Recent Publications by NAVBO Members

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution
Uncovering mechanisms that control immune responses in the resolution of bacterial infections is critical for the development of new therapeutic strategies that resolve infectious inflammation without unwanted side effects. We found that disruption of the vagal system in mice delayed resolution of Escherichia coli infection.  Read more


T-type Ca2+ channels and Autoregulation of Local Blood Flow
L-type voltage gated Ca2+ channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca2+ channels. Recent studies suggest that these channels may also play a role in autoregulation.  Read more


Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model
PLoS Commputational Biology
Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of new blood vessels. Besides an increase in the production of pro-angiogenic signals such as vascular endothelial growth factor (VEGF), hypoxia also stimulates the production of anti-angiogenic signals. Thrombospondin-1 (TSP-1) is one of the anti-angiogenic factors whose synthesis is driven by hypoxia.  Read more


Thrombospondin-1 Gene Polymorphism Is Associated with Estimated Pulmonary Artery Pressure in Patients with Sickle Cell Anemia
American Journal of Hematology
 Read more


Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli
Journal of Clinical Investigation Insight
In patients with sickle cell disease (SCD), the polymerization of intraerythrocytic hemoglobin S promotes downstream vaso-occlusive events in the microvasculature. While vaso-occlusion is known to occur in the lung, often in the context of systemic vaso-occlusive crisis and the acute chest syndrome, the pathophysiological mechanisms that incite lung injury are unknown.  Read more


Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication
PLoS One
Approximately 30% of tumor endothelial cells have over-duplicated (>2) centrosomes, which may contribute to abnormal vessel function and drug resistance. Elevated levels of vascular endothelial growth factor A induce excess centrosomes in endothelial cells, but how other features of the tumor environment affect centrosome over-duplication is not known.  Read more

Industry News (from the January 5 issue)
Who owns commercial rights to CRISPR-Cas9 technology?
Attorneys representing UC-Berkeley and the Broad Institute of MIT and Harvard, juggernauts in both basic biomedical science and its application, are slugging it out in hearings before a panel of judges at the US Patent and Trademark Office to settle the ownership of key CRISPR-Cas9 intellectual property whose value may surpass $1E9. Nature reports  that the USPTO judges questioned Berkeley's main claim that any reasonably skilled person could have adapted its bacterial technique for use in eukaryotic cells (as accomplished by the Broad patent awardees) once the Berkeley researchers had demonstrated that CRISPR-Cas9 could be used to edit DNA in a prokaryote. Predictions are that the USPTO will issue a ruling in the case within the next two months.
Evidence-based medicine in the news
A list of "The Top 10 Censored Stories of 2015-16" has been assembled by Project Censored in an effort to highlight news stories deemed to have received insufficient attention considering their potential social ramifications. Number 2 on the list is "Crisis in evidence-based medicine," exploring the scrutiny currently coming to bear from all quarters regarding reproducibility in academic biomedical science and the perils of commercial influence. In mid-December, The Boulder Weekly  featured an annotated version of the list's top ten, including " Big Pharma political lobbying not limited to presidential campaigns" (#9).
A new form of cap for R01s?
Based in part on an analysis suggesting that per-dollar research productivity may diminish as labs become larger, Michael Lauer, Chief of NIH's Office of Extramural Research, has raised the question of whether a cap on the total number of grants an investigator could receive would provide a means of funding thousands more researchers, particularly new and midcareer investigators, without any drop-off in scientific output. The National Institute of General Medical Sciences has such policies in place already, and an internal NIH working group is considering their broader deployment. (reported in Science )
Job Postings
Job Title
University of North Carolina
Chapel Hill, NC
Postdoctoral Fellow
University of Washington
Seattle, WA
Stanford School of Medicine
Stanford, CA
Calendar of Events
May 8-12, 2017
Keystone Symposia Conference - Angiogenesis and Vascular Disease
June 8-10, 2017
Lymphatic Forum 2017
June 8-11, 2017
12th HHT International Scientific Conference
July 24-27, 2017
Vasculata 2017
Aug. 11-14, 2017
2017 APS Conference: Cardiovascular Aging, New Frontiers and Old Friends
Oct. 15-19, 2017
Vascular Biology 2017
May 30 - June 1, 2018
22nd International Workshop on Vascular Anomalies
June 4-7, 2018
20th International Vascular Biology Meeting
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