September 28, 2017
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Meetings
 
Vascular Biology
Monterey, CA  
October 15-19, 2017
What's inside the VB2017 Conference Bag?   Click it to find out! 
  20th IVBM   Helsinki, Finland   June 3-7, 2018 
 
Vasculata 2018
St. Louis, MO   July 23 - 26, 2018 
Vascular Biology
Newport, RI
October 14-18, 2018 
Corporate Partners
Corporate Members
Affiliated Journals
Congratulations to
Angiogenesis!
The new 2016 impact factor for Angiogenesis has increased to 5.253*.
 
* 2016 Journal Citation Reports (Clarivate Analytics, 2017)
Cardiovascular Medicine
VB 2017 Supporters






VB 2017 Exhibitors
Vascular Biology 2017


View/download the abstracts (full text is NOT included)

There is still time to register for the meeting! 
Go to:www.navbo.org/events/vb2017/registration
How-To Session at Vascular Biology
Basics of Fluid Dynamics and Shear Stress Definition in Flow Experiments
An Exhibitor Showcase Sponsored by ibidi

Cell types, such as endothelial cells of blood and lymphatic vessels as well as epithelial cells of kidney and lung, are permanently experiencing the mechanical stimulus of the fluid flow under physiological conditions. This mechanical stimulus is known as shear stress. To approach these conditions
in vitro, the application of a defined flow (and thus shear stress) over the cell layer is necessary.

This session outlines the importance of flow conditioning by selected publications and gives you references of typical shear stress values in various tissues.

Learn how to establish a defined experimental setup for generating reproducible results.

Moreover, this session will provide a basic understanding of fluid dynamics in small channels and explains how to calculate the shear stress on the cells.

Further, example calculations are given for various ibidi Channel Slides, offering an easy and convenient solution for flow experiments.

This showcase will give you a profound understanding of fluid dynamics, which is crucial to establish flow experiments in your own lab.
Spotlight on Trainees
Congratulations to the Vascular Biology 2017 Travel Award Recipients:

Vascular Matrix Biology and Bioengineering Workshop:
Gabriela Espinosa, Washington University in St. Louis
David Howell, Texas A&M Health Science Center
Andrew Kim, Cincinnati Children's Hospital Medical Center
Christopher Koch, Cleveland Clinic Lerner Research Institute
Heena Kumra, McGill University
Vivian Lee, Washington University in St. Louis
 
10th Anniversary Travel Awards*
Julian Albarran Juarez, Max Planck Institute for Heart and Lung Research
Luis Hortells, University of Pittsburgh
Jason Lee, University of Texas at Austin
Albertomaria Moro, Yale University School of Medicine
David Ngai, University of Toronto, Ted Rogers Centre for Heart Research
Shouka Parvin Nejad, University of Toronto, Ted Rogers Centre for Heart Research

Developmental Vascular Biology and Genetics Workshop:
Boksik Cha, Oklahoma Medical Research Foundation
Sarah Colijn, Oklahoma Medical Research Foundation
Thanh Theresa Dinh, Stanford University
Federica Fontana, University of Potsdam
Gael Genet, Yale School of Medicine
Yao Wei Lu, Albany Medical College
Julie Perlin, Boston Children's Hospital
 
General Sessions:
Ashraf Ul Kabir, Washington University in St. Louis
Anastasia Kyselova, Goethe University Frankfurt
Bendix Slegtenhorst, Brigham and Women's Hospital/Harvard Medical School

NAVBO Merit Award:
Amber Stratman, NICHD/NIH
 
Funding for the Travel Awards is provided by a grant from the National Heart, Lung, and Blood Institute.
* Special awards commemorating the 10th Anniversary of the Vascular Matrix Biology and Bioengineering Workshop are being funded by:  Department of Laboratory Medicine and Pathobiology, Translational Biology & Engineering Program, Institute for Biomaterials & Bioengineering, and the Faculty of Medicine at the University of Toronto
Lessons Learned
Mete Civelek, Ph.D.
University of Virginia
I started my laboratory at the Center for Public Health Genomics at the University of Virginia about two years ago. I made several good decisions as well as several mistakes during this time. While everyone's experiences will be different, I would like to share some of the lessons I learned with the hope that you will make wiser choices when you start your research group.

I immediately found a group of like-minded junior PIs who also started their labs around the same time as me at UVA. This group has been a great support both mentally and scientifically. In fact, four of us hold joint lab meetings together as we have overlapping interests. If you are just starting your lab, I highly recommend to you to be part of the New PI Slack, which is a community of about 400 junior faculty members primarily across the United States ( https://newpislack.wordpress.com/). This is a group of generous and thoughtful new PIs who share many things from examples of grant applications to advice for wet lab and computational tools, funding opportunities, how to deal with diversity-related issues, and even tips for work-life balance.  Read more at http://www.navbo.org/resources/lessons-learned.
If you have insights to share, contact [email protected] 
Lab of the Month
The Lab of Dr. Mete Civelek
This month we are highlighting the lab of Dr. Mete Civelek, who is an Assistant Professor of Biomedical Engineering at the University of Virginia. Find out more about Dr. Civelek and his lab at http://www.navbo.org/membership/members-labs/636-lab092017.
Member News
Congratulations Dr. Wu
Hao Wu, Ph.D., of Boston Children's Hospital was awarded an AWRP Summer Scientist Development Grant, titled "Role of Epsins in Sepsis," from the American Heart Association.  This AHA funding mechanism aims to support highly promising beginning investigators in cardiovascular and stroke research as they progress from initial research training to complete independence. Dr. Wu's research in structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially those of the innate immune system.
(Erratum:  originally published in the June 2017 Newsletter with the wrong photo.  Our apologies to Dr. Wu, Vascular Biology Program, Boston Children's Hospital) 
Welcome to our Newest Members:
Marie Altendahl, University of California, San Francisco
Richard S. Beard, Boise State University
Alexandre Dubrac, Yale University
Fanny Elahi, University of California, San Francisco
Oscar Fajardo, Brigham and Women Hospital
Genki Hayashi, University of California, San Francisco
Jiong Hu, Institute for Vascular Signalling
Anastasia Kyselova, Goethe University Frankfurt
Tyler Nelson, Georgia Institute of Technology
Zhanna Nepiyushchikh, Georgia Institute of Technology
Brian Wong, Washington University School of Medicine
If you have news to share with your colleagues, send it to [email protected].
 Recent Publications by NAVBO Members

The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity
Cell Metabolism
Obesity is a key risk factor for metabolic and cardiovascular diseases, and although we understand the mechanisms regulating weight and energy balance, the causes of some forms of obesity remain enigmatic.  Read more

 

ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis
Journal of Clinical Investigation Insight
The authors have recently reported that tumor-associated macrophages (TAMs) promote early transcoelomic metastasis of ovarian cancer by facilitating TAM-ovarian cancer cell spheroid formation.  Read more

 

Endothelial Cell Function and Dysfunction in Critically Ill Children
Pediatrics
Endothelial cells (ECs) line the lumen of the entire vascular system and actively regulate blood flow; maintain blood fluidity; control water, solute, and macromolecular transfer between blood and tissue; and modulate circulating immune cell recruitment and activation.  Read more

 

A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration
American Journal of Pathology
Current treatments for choroidal neovascularization, a major cause of blindness for patients with age-related macular degeneration, treat symptoms but not the underlying causes of the disease. Inflammation has been strongly implicated in the pathogenesis of choroidal neovascularization.  Read more

 

Inflammatory signaling cascades and autophagy in cancer
Autophagy
Tumor-associated inflammation is predictive of poor prognosis and drives a variety of tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis, invasiveness, and metastasis.  Read more

 

A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity
Scientific Reports
Endothelial barrier function is carefully controlled to protect tissues from edema and damage inflicted by extravasated leukocytes. RhoGTPases, in conjunction with myriad regulatory proteins, exert both positive and negative effects on the endothelial barrier integrity.  Read more
Job Postings
Job Title
Company
Location
University of Illinois at Chicago
 Chicago, IL
Assistant Postdoctoral Fellow Position
Johns Hopkins University
Baltimore, MD
UC Berkeley
 Berkeley, CA
Postdoctoral Fellow
Cincinnati Children's Hospital
Cincinnati, OH
University of Pittsburgh
 Pittsburgh, PA
Postdoctoral Position
University of California, Riverside
Riverside, CA
Imperial College London
 London, England
Postdoc/Research Associate
Case Cardiovascular Institute
Cleveland, OH
Calendar of Events
Oct. 4-7, 2017
 4th Latin American Glycobiology Meeting
Oct. 15-19, 2017
 Vascular Biology 2017
Oct. 25-26, 2017
 2017 NHLBI Systems Biology Symposium
Nov. 29 - Dec. 1, 2017
 XXXIII LIAC Meeting - VIVA winter school on vascular aging
June 3-7, 2018
 20th International Vascular Biology Meeting
June 9-12, 2018
 XVIII International Symposium on Atherosclerosis
North American Vascular Biology Organization | [email protected] | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211

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