Stasis Promotes Erythrocyte Adhesion to von Willebrand Factor
Arteriosclerosis, Thrombosis, and Vascular Biology
OBJECTIVE: Venous thromboembolism is a major contributor to global disease burden. Leukocytes and platelets initiate thrombogenesis on blood stasis and initiate the formation of a fibrin, VWF (von Willebrand factor), and neutrophil extracellular trap scaffold for erythrocytes.  Read more

Polyester vascular patches acquire arterial or venous identity depending on their environment
Journal of Biomedical Materials Research Part A
Polyester is commonly used in vascular surgery for patch angioplasty and grafts. We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted to the Wistar rat aorta or inferior vena cava and explanted on days 7 or 30.  Read more

Identifying early pathogenic events during vascular calcification in uremic rats
Kidney International
Vascular calcification in chronic kidney disease is a very complex process traditionally explained in multifactorial terms. Here the authors sought to clarify relevance of the diverse agents acting on vascular calcification in uremic rats and distinguish between initiating and complicating factors. After 5/6 nephrectomy, rats were fed a 1.2% phosphorus diet and analyzed at different time points.  Read more

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential
Scientific Reports
Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function. However, evidence suggests that their regenerative capacity may be limited in conditions of severe hypoxia.  Read more

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
Nature Communications
Several cell-based therapies are under pre-clinical and clinical evaluation for the treatment of ischemic diseases. Poor survival and vascular engraftment rates of transplanted cells force them to work mainly via time-limited paracrine actions.  Read more

Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model
Scientific Reports
Pericytes represent important support cells surrounding microvessels found in solid organs. Emerging evidence points to their involvement in tumor progression and metastasis.  Read more

YAP/TAZ-CDC42 signaling regulates vascular tip cell migration
PNAS
Angiogenesis and vascular remodeling are essential for the establishment of vascular networks during organogenesis. Here the authors show that the Hippo signaling pathway effectors YAP and TAZ are required, in a gene dosage-dependent manner, for the proliferation and migration of vascular endothelial cells (ECs) during retinal angiogenesis.  Read more