October 12, 2017
Home           Membership           Events           Awards           Resources
In This Issue
Join      Rejoin     Renew
Vascular Biology
Monterey, CA  
October 15-19, 2017
What's inside the VB2017 Conference Bag?   Click it to find out! 

  20th IVBM   Helsinki, Finland   June 3-7, 2018 

Vasculata 2018
St. Louis, MO
  July 23 - 26, 2018 
Vascular Biology
Newport, RI
October 14-18, 2018 
Corporate Partners
Corporate Members
Affiliated Journals
Congratulations to
The new 2016 impact factor for Angiogenesis has increased to 5.253*.
* 2016 Journal Citation Reports (Clarivate Analytics, 2017)
Cardiovascular Medicine
VB 2017 Supporters

VB 2017 Exhibitors
Vascular Biology 2017

View/download the abstracts (full text is NOT included)

There is still time to register for the meeting! 
Go to:www.navbo.org/events/vb2017/registration

Spotlight on Trainees
To intern or not to intern...that is the question
Working as an intern while pursuing a doctoral degree can significantly enhance a graduate student's professional development. Internships offer the chance to acquire experience beyond that available on one's home turf and to get a more rounded perspective on what long-term work in a given field may be like. Is seeking an internship the right choice for all students? There is no simple answer to this question, and an informed choice would include consideration of a trainee's educational level. Survey findings reported by the National Association of Colleges and Employers suggest that completion of paid internships by undergraduates may increase their likelihood of subsequently receiving offers of full-time employment. For PhD students and postdocs, the answer may vary with field of interest and eventual career aspirations. The Cheeky Scientist addresses this issue in a recent video posting on Facebook.
Lab of the Month
The Lab of Dr. Anna Randi
This month we are highlighting the lab of Dr. Anna Randi, who is a Professor of Cardiovascular Medicine at the National Heart and Lung Institute, Imperial College London. Find out more about Dr. Randi and her lab at http://www.navbo.org/membership/members-labs/643-lab102017.
Member News
Welcome to our Newest Members:
Xitao Wang, University of California, San Francisco
Thidathip Wongsurawat, University of Arkansas for Medical Sciences
If you have news to share with your colleagues, send it to membership@navbo.org.
 Recent Publications by NAVBO Members

Stasis Promotes Erythrocyte Adhesion to von Willebrand Factor
Arteriosclerosis, Thrombosis, and Vascular Biology
OBJECTIVE: Venous thromboembolism is a major contributor to global disease burden. Leukocytes and platelets initiate thrombogenesis on blood stasis and initiate the formation of a fibrin, VWF (von Willebrand factor), and neutrophil extracellular trap scaffold for erythrocytes.  Read more


Polyester vascular patches acquire arterial or venous identity depending on their environment
Journal of Biomedical Materials Research Part A
Polyester is commonly used in vascular surgery for patch angioplasty and grafts. We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted to the Wistar rat aorta or inferior vena cava and explanted on days 7 or 30.  Read more


Identifying early pathogenic events during vascular calcification in uremic rats
Kidney International
Vascular calcification in chronic kidney disease is a very complex process traditionally explained in multifactorial terms. Here the authors sought to clarify relevance of the diverse agents acting on vascular calcification in uremic rats and distinguish between initiating and complicating factors. After 5/6 nephrectomy, rats were fed a 1.2% phosphorus diet and analyzed at different time points.  Read more


Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential
Scientific Reports
Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function. However, evidence suggests that their regenerative capacity may be limited in conditions of severe hypoxia.  Read more


Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
Nature Communications
Several cell-based therapies are under pre-clinical and clinical evaluation for the treatment of ischemic diseases. Poor survival and vascular engraftment rates of transplanted cells force them to work mainly via time-limited paracrine actions.  Read more


Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model
Scientific Reports
Pericytes represent important support cells surrounding microvessels found in solid organs. Emerging evidence points to their involvement in tumor progression and metastasis.  Read more


YAP/TAZ-CDC42 signaling regulates vascular tip cell migration
Angiogenesis and vascular remodeling are essential for the establishment of vascular networks during organogenesis. Here the authors show that the Hippo signaling pathway effectors YAP and TAZ are required, in a gene dosage-dependent manner, for the proliferation and migration of vascular endothelial cells (ECs) during retinal angiogenesis.  Read more

Industry News
Prospects for increased NIH funding in FY2018
In early September, the US Senate's Labor, Health and Human Services, and Education Appropriations Subcommittee approved a
$2 billion increase to the NIH budget for the 2018 fiscal year that began 1 October. Amounting to a 6% raise, this figure well exceeds that approved by a House of Representatives panel and sharply contrasts with President Trump's desired 22% cut. The dramatic reductions in overhead costs sought by the administration are absent from Senate's draft spending bill. Principal beneficiaries of the proposed increase are research on Alzheimer's disease ($414 million in new spending), the Brain Research through Advancing Innovative Neurotechnologies brain-mapping initiative ($140 million increase) and the All of Us precision medicine study ($60 million jump). The eventual fate of the Senate proposal budget awaits further consideration later this fall; the Federal government currently is operating under a continuing resolution.

New temporary assist device approved for right side heart failure  
The Impella RP right ventricular assist device has been approved by the FDA for up to 14 days of use in patients meeting certain body and cardiac history criteria (acute right heart failure (RVF) or decompensation after left ventricular assist device implantation, myocardial infarction, heart transplant, or open-heart surgery). The device's developer, Abiomed, cites findings in the prospective, multicenter, single-arm RECOVER RIGHT study, showing a 73.3% 30-day survival rate in patients in the target population. The trial authors conclude that " in patients with life-threatening RVF, the novel percutaneous Impella RP device was safe, easy to deploy, and reliably resulted in immediate hemodynamic benefit. These data support its probable benefit in this gravely ill patient population."

Non-invasive three-part screening for cardiovascular risk
The Danish   Viborg Vascular (VIVA) study, reported at the annual congress of the European Society of Cardiology and in The Lancet , suggests that screening for high blood pressure, abdominal aortic aneurysm and peripheral artery disease was linked to a 7% reduction in mortality. The study, involving 50,000 male subjects who underwent various permutations of the three screening modalities, used national registries for hospital admissions, surgeries, and overall and cause-specific death. VIVA investigator Jes Lindholt, MD, of Odense University Hospital noted that the mortality reductions may be "...primarily explained by the 2.5 times higher incidence of elective aneurysm repairs and the doubled initiation rates of anti-thrombotic and lipid-lowering therapy in the group invited to screening."

Job Postings
Job Title
University of Illinois at Chicago
Chicago, IL
Postdoctoral Fellow Position
Johns Hopkins University
Baltimore, MD
UC Berkeley
Berkeley, CA
Postdoc/Research Associate
Case Cardiovascular Institute
Cleveland, OH
University of Illinois at Chicago
Chicago, IL
Postdoctoral Position
University of California, Riverside
Riverside, CA
Calendar of Events
Oct. 15-19, 2017
Vascular Biology 2017
Oct. 25-26, 2017
2017 NHLBI Systems Biology Symposium
Nov. 29 - Dec. 1, 2017
XXXIII LIAC Meeting - VIVA winter school on vascular aging
Feb. 25-March 1, 2018
Keystone Symposia: Vascular Biology and Human Diseases: From Molecular Pathways to Novel Therapeutics
May 31-June 1br> 22nd International Workshop on Vascular Anomalies
June 3-7, 2018
20th International Vascular Biology Meeting
June 9-12, 2018
XVIII International Symposium on Atherosclerosis
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211