May 30, 2019
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Vascular Biology 
Monterey, CA  

Vasculata 2019
Medical College of Wisconsin
July 13 - 18, 2019

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Affiliated Journals
Partner Network Advantage - New Job Board Feature
Why post your job on NAVBO's career center rather than going directly to the larger job networks?
Pricing on the mass job boards can vary, but to get a job noticed you typically have to sponsor it for $5 - $10 per day, which can add up quickly especially since you also pay for each click the job gets. When you add it all together, you could be spending up to $45 per day on your job posting. But, when posting a job on NAVBO's career center, you simply pay a flat fee! The Premium package includes our Exclusive Extended Partner Network - which means the jobs are broadcast to sites like ZipRecruiter and Jobs2Careers and more for a flat fee.
 
With special member pricing, you can post a job for as low as $300 with this Partner Network. You never pay for each click, just the flat fee on the NAVBO career center. In addition, the Premium package includes a 60-day job posting making it a great value. The Premium packages also offer features like having your company's logo featured on the career center homepage, having your job appear first in search results, and more.
 
Post your open position now at www.navbo.org/jobs! 
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Help Support NAVBO 
NAVBO Privacy Policy
Your data privacy and security are important to NAVBO. To that end, we have updated our privacy policy to reflect recent privacy and security regulation implementations and changes. Please review our policy as time permits so you have a complete understanding of the data we have, why we have it, and how we use it.
 
Part of the updates relate directly to the European Union's new General Data Protection Regulation (GDPR) that went into place May 25.   The GDPR seeks to improve the transparency of data usage and give end users more control over their own data. We believe these changes are important and will be compliant with the GDPR regulations.
 
Contact NAVBO if you have any questions or to change your communication preferences.
 
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*Product News is a paid advertising space. For more information go to: http://www.navbo.org/images/MediaKit-NewsBEAT.pdf
Vasculata 2019 - Register Today!
Vasculata 2019 - July 15-18 
Medical College of Wisconsin
 
Abstract Deadline and the  
Early bird deadline is June 3!!! 



Join us in Milwaukee this summer for the 15th Vasculata.
Check out the exciting preliminary program!!  There are several hands-on workshops, keynote talks by Luisa Iruela-Arispe and Curt D. Sigmund, and new this year - a mentoring program for attendees that will last way beyond Vasculata, plus selected abstracts will be chosen as short talks (also new) and of course poster sessions and lectures. Go to http://www.navbo.org/events/vasculata2019 for more information.

Register today (early bird deadline is June 3) -
Submit your abstract (deadline is June 3) -
Travel Award to the Angiogenesis GRC
NAVBO will Present a $500 Travel Award to a Trainee Member
As NAVBO has done in the past, we are accepting applications from NAVBO trainee members (your PI must also be a NAVBO member) for this Travel Award.  See criteria and more information on our web site.  Applications must be received by June 17.
Seeking Postdoctoral Fellows for Education Committee
The Education Committee is looking for postdoctoral fellows to join the committee. This is your opportunity to make a difference by enhancing the trainee member's experience, network with a great group of scientists, and gain leadership experience with this great organization! If you're interested in joining us, please apply today!

Applicants should expect to serve a three-year term. Applications must include: your CV, a letter from your supervisor attesting to your leadership quality, a brief statement from you concerning your commitment to the vascular biology community and this society, and what you would like to bring to this committee. Please forward this information to ( membership@navbo.org) by June 14, 2019.

If you have further questions about the Education Committee or the application process, please feel free to contact Bernadette ( bernadette@navbo.org) or Mary Jo Mulligan-Kehoe, the Committee Chair ( education@navbo.org).
June Webinar with Daniel Greif
Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain
Join  us on June 13 - at 1:00pm EDT for a webinar featuring Dr. Daniel Greif of Yale University.  His presentation will reveal a key role for PC ALK5 in regulating brain endothelial morphogenesis and a substantial therapeutic potential for TIMP3 during GMH-IVH.  

For more details and to register go to: http://www.navbo.org/events/webinars/807-web062019
 
NAVBO Webinars are free to current NAVBO Members.

Don't Miss These Upcoming Webinars:
July 11 - Kishore Wary, University of Illinois at Chicago
August 8 - Vicki Bautch, University of North Carolina at Chapel Hill 
 
And don't forget you can watch archived webinars as well - go to  
Spotlight on Trainees
Gates Foundation to support trainee travel to select Keystone Symposia
The Bill & Melinda Gates Foundation is inviting applications  for Global Health Travel Awards, in support of participation in select Keystone Symposia meetings. Scientists, students, and post-doctoral fellows from a nation affected by one of the health problems addressed by selected meeting topics  are eligible to apply. Preference will be given to individuals traveling from and returning to affected nations, or individuals currently studying in another country, but planning to return to work in an affected nation. The award will cover conference-related expenses to include meeting registration, shared lodging, economy airfare and ground transportation from host airport to the meeting location. Designated meeting topics of relevance to vascular biology include Maternal-Fetal Crosstalk , featuring sessions on "The Placenta in Health and Disease" and "Immunity at the Maternal-Fetal Interface."
Call for Papers - Single-Cell Anaylysis
A Frontiers Research Topic initiated by NAVBO
Recent advances in analyzing tissues and organs at the single cell (SC) level are revolutionizing our understanding of organ development, biology, and disease. Previously, the genetic composition or transcriptional profiles of cells was based on sequencing DNA or RNA from a large number of cells, but this approach loses information on the heterogeneity of individual cells. Sequencing DNA and RNA from individual cells preserves heterogeneity, and technological advances have made these techniques highly accessible.

A recent analysis - available here - of the SC extramural research funded by the NIH, either through NIH-initiated programs focused on SC or initiated by extramural investigators, revealed the paucity of such analyses related to vascular cells compared to a variety of other cells and tissues. This Research Topic is seeking to galvanize interest in SC applications related to the field of vascular cell biology and highlight original research related to SC analyses of vascular related cells, under normal or diseased conditions. We seek to understand the specific challenges associated with studying vascular cells, and how advances in SC approaches could benefit vascular fields. More information can be found here on the Frontiers web site.
Product News*
Introducing ACS Pharmacology & Translational Science

ACS Pharmacology & Translational Science
 is a new journal from the American Chemical Society publishing high-quality, innovative research across the broad spectrum of biological sciences.
 
Read Volume 2, Issue 1, free courtesy of ACS Publications.  
 
 
 
And don't miss NAVBO member Professor Kathleen M. Caron's latest work in our Articles ASAP.
Lab of the Month
The Lab of Delphine Gomez

This month we are highlighting the lab of Dr. Delphine Gomez, an Assistant Professor in the Department of Medicine at the University of Pittsburgh. Find out more about Dr. Gomez and her lab at  http://www.navbo.org/membership/members-labs/806-lab052019.  
Summer Training for Junior Faculty
Programs to Increase Diversity Among Individuals Engaged in Health-Related Research
The NHLBI PRIDE Program is offering nine unique Summer Institute programs with intensive mentored training opportunities to enhance the research skills and to promote the scientific and career development of trainees. Trainees will learn effective strategies for preparing, submitting and obtaining external funding for research purposes, including extensive tips on best practices. Trainees will also be able to apply for small grants to support mentored-pilot research projects. Research emphasis varies by program.
   
Eligible applicants are junior-level faculty or transitioning postdoctoral scientists with background deemed under-represented in the biomedical or health sciences. Research interests should be compatible with those of the National Heart, Lung, and Blood Institute (NHLBI) in the prevention and treatment of heart, lung, blood, and sleep (HLBS) disorders.   
 
Of particular interest to NAVBO members are the programs on Cardiovascular Disease Comorbidities, Genetics and Epidemiology (CVD-CGE) (July 17-31, 2019) and Cardiovascular Health-Related Research (CVD) (July 7-19, 2019).
 
Apply early - there are a limited number of positions and admission will close when spaces are filled. 
 
Visit the web site at https://pridecc.wustl.edu
Member News
Welcome to our New Members:
Yu-Chun Chang, Nationwide Children's Hospital
Pamela Horton, St. Edward's University
Yoshito Yamashiro, University of Tsukuba

If you have news to share with your colleagues, send it to membership@navbo.org
 Recent Publications by NAVBO Members

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription
Circulation Research
Rationale: Neointimal hyperplasia is characterized by excessive accumulation of vascular smooth muscle cells (SMCs) leading to occlusive disorders such as atherosclerosis and stenosis.  Read more

 

FAK and Pyk2 activity promote TNF-? and IL-1?-mediated pro-inflammatory gene expression and vascular inflammation
Scientific Reports
Protein tyrosine kinase (PTK) activity has been implicated in pro-inflammatory gene expression following tumor necrosis factor-a (TNF-a) or interkeukin-1ß (IL-1ß) stimulation. However, the identity of responsible PTK(s) in cytokine signaling have not been elucidated.  Read more

 

Increased circulating levels of Epidermal Growth Factor-like Domain 7 in pregnant women affected by preeclampsia
Translational Research
Proper placental development is crucial to establish a successful pregnancy. Defective placentation is the major cause of several pregnancy complications, including preeclampsia (PE).  Read more

 

miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta
Developmental Biology
A functional placenta develops through a delicate interplay of its vascular and trophoblast compartments. We have identified a previously unknown expression domain for the endothelial-specific microRNA miR-126 in trophoblasts of murine and human placentas.  Read more

 

iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications
Nature Communications
Most biomedical research aimed at understanding gene function uses the Cre-Lox system, which consists of the Cre recombinase-dependent deletion of genes containing LoxP sites.   Read more

 

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
Cells
Most biomedical research aimed at understanding gene function uses the Cre-Lox system, which consists of the Cre recombinase-dependent deletion of genes containing LoxP sites. This system enables conditional genetic modifications because the expression and activity of the recombinase Cre/CreERT2 can be regulated in space by tissue-specific promoters and in time by the ligand tamoxifen.  Read more

 

Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation
Journal of Neurosurgery
A high level of vascular endothelial growth factor (VEGF) has been implicated in brain arteriovenous malformation (bAVM) bleeding and rupture. However, direct evidence is missing. In this study the authors used a mouse bAVM model to test the hypothesis that elevation of focal VEGF levels in bAVMs exacerbates the severity of bAVM hemorrhage.  Read more

Industry News (from the May 2 issue)
USDA Research Arm to Eschew Use of Cats as Experimental Subjects
The US Department of Agriculture's Agricultural Research Service has decided to discontinue the use of cats in all ARS research. As reported by the National Association for Biomedical Research (NABR), the ARS has been the target of an extended animal rights campaign waged by the White Coat Waste Project. Among other projects, the ARS has long studied transmission and pathophysiology of toxoplasmosis in cats. NABR is also following a proposed rule by the USDA's Animal and Plant Health Inspection Service to modify requirements for licensing in research using dogs.

HHS and NIH Leaders Testify to Congress on Biomedical Research Funding
Members of the senior NIH leadership, including Director Francis Collins and five institute directors, appeared on Capitol Hill April 2 to testify before the House Appropriations Labor-HHS Subcommittee.  At issue was the president's proposed FY2020 budget, which calls for cuts in the NIH budget characterized by House members as out of step with Subcommittee's bipartisan support of medical research. Two days later, the Senate Labor-HHS Subcommittee heard budget-related testimony from HHS Secretary Alex Azar. More details are available in the AAMC's Washington Highlights.

Stable Cardiovascular Mortality in States that Expanded Medicaid
The expansion of Medicaid occurring under the Affordable Care Act (ACA) has been associated with reduced deaths attributable to cardiovascular disease. A study, reported in MEDPAGE TODAY and using data from a Centers for Disease Control mortality database, indicated that cardiovascular mortality rates among middle-age adults was stable in states opting for Medicaid expansion, while mortality increased in non-expansion states (176.3 to 180.9 deaths per 100,000 residents per year; P=0.001). The biggest impact in cardiovascular deaths was found in non-metropolitan counties and in areas with the most residents living in poverty.
Job Postings
Job Title
Company
Location
Cincinnati Children's Hopsital
Cincinnati, OH
Postdoctoral position in Vascular Development
UMass Medical School
Worcester, MA
Columbia University
New York, NY
Post-doctoral Fellow
OMRF
Oklahoma City, OK
University Health Network
Toronto, ON
Calendar of Events
May 30 - June 1, 2019
Lymphatic Forum 2019
June 12 - 16, 2019
13th HHT International Science Conference
June 22 - 25, 2019
ASMB Workshop 2019 - Fibroblasts: the Arbiters of Matrix Remodeling
July 6 - 10, 2019
International Society on Thrombosis and Hemostasis Congress 2019
July 21 - 26, 2019
GRC - Elastin, Elastic Fibers, and Microfibrils
Oct. 27 - 31, 2019
Vascular Biology 2019
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211