Findings published in Clinical Trials suggest that the majority of patients do not feel a personal responsibility to participate in clinical research. NIH Collaboratory members Kevin Weinfurt, Li Lin, and Jeremy Sugarman reported this information based on a national study of nearly 3,000 people regarding their attitudes toward research responsibilities, as well as their trust in doctors, healthcare systems, and medical research.
New Living Textbook Section on Inpatient Endpoints in Pragmatic Clinical Trials: Sources of patient information in pragmatic clinical trials may include the electronic health record, claims from Medicare or health insurers, and patient reports. There are a number of considerations for using these “real-world” data for inpatient-based event ascertainment. This new section of the Living Textbook defines how inpatient events are classified, describes the different data sources that can be used for inpatient event ascertainment, and includes information about the reliability of these data sources.
Trial Spotlight
Congratulatio ns to PRIM-ER and ACP PEACE o n their transitions from the UG3 planning phase to the UH3 implementation phase.   Click on the links below to read full interviews with the Demonstration Project investigators about their trial experiences so far.
PrincipaI Investigator: Corita Grudzen, MD, MSHS, FACEP
Dr. Grudzen’s advice for those conducting pragmatic trials: “Be patient and flexible and open to new iterations of what you’re doing. It feels scary at first, but I think it will serve you to be open to change.”
Co-Principal Investigators:
James A. Tulsky, MD;
Angelo Volandes, MD, MPH
Dr. Volandes on the biggest surprise during the trial’s planning phase: “The biggest surprise was that most clinicians don’t use the structured variable in the electronic health record (EHR) that we were going to use to extract our primary outcome. The workaround, which I think is actually better, is to use natural language processing (NLP) to abstract our primary outcome from the free text of the clinical note in the EHR.”
Grand Rounds Roundup
Upcoming Grand Rounds

August 2: AI and the Future of Psychiatry (Murali Doraiswamy, MBBS)

August 16: Introducing the Digital Medicine Society (DiMe) ( Andy Coravos; Jen Goldsack, MBA)


Featured in the Living Textbook
Pragmatic clinical trials often face unique challenges because of their less structured approach and because they are often embedded within the workflows of large healthcare systems. We recently revised the Unanticipated Changes section of the Living Textbook to provide more current information on unanticipated changes during study implementation that investigators should consider in advance so that the impact of such changes can be minimized during the planning phase. Learn more in the Analysis Plan chapter of the Living Textbook.