During the preconference seminar, investigators from the NIH Collaboratory Coordinating Center, Core Working Groups, and Demonstration Projects, and officials from the NIH and the Office of Human Research Protections introduced nearly 50 attendees to concepts in the design, conduct, and implementation of embedded pragmatic clinical trials (ePCTs), with a focus on methods relevant to health services researchers. Access the full set of training materials in the Living Textbook.
SPOT Illustrates Use of Real-World Health System Data in Designing Embedded Pragmatic Clinical Trials: Investigators from the Suicide Prevention Outreach Trial (SPOT), an NIH Collaboratory Demonstration Project, recently shared their experiences with using electronic health record data on patients in the trial's participating health systems to inform trial design. The article was published in  Clinical Trials .
EMBED Investigators Discuss Progress and Transition to Implementation Phase : At the May 2019 NIH Collaboratory Steering Committee meeting, members of the Coordinating Center staff spoke with principal investigators Ted Melnick and Gail D'Onofrio about the Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder (EMBED), an NIH Collaboratory Demonstration Project. The conversation highlights challenges the study faced during the UG3 planning phase and offers advice for investigators conducting their first ePCT.
Trial Spotlight
Guiding Good Choices for Health (GGC4H): Congratulations to the GGC4H team on receiving approval to move from the planning phase to the implementation phase of their NIH Collaboratory Demonstration Project. At the May NIH Collaboratory Steering Committee meeting, principal investigators Stacy Sterling, Margaret Kuklinski, and Richard Catalano discussed the study's progress and challenges during the UG3 planning phase. Read the full interview and find more information about GGC4H in the Living Textbook.
Grand Rounds Roundup
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Upcoming Grand Rounds

June 28: Moving Beyond Return of Research Results to Return of Value (Consuelo H. Wilkins, MD, MSCI)

July 12: medRxiv: A Paradigm Shift in Disseminating Clinical and Public Health Research (Harlan M. Krumholz, MD, SM; Joseph S. Ross, MD, MHS)

Featured in the Living Textbook
Want to know what all was covered at the May 2019 Steering Committee Meeting? The meeting materials are now available online . Day 1 included discussions on perspectives on the landscape of ePCTs and the need for real-world evidence, data sharing policy and planning, and more. Day 2 featured an intensive workshop hosted by the NIH with the goal of starting discussions on statistical issues in ePCTs.