Results of the Active Bathing to Eliminate (ABATE) Infection trial were published in The Lance t on March 5. The findings suggest universal decolonization did not significantly reduce infection of multidrug-resistant organisms in non-critical-care patients. However, in post-hoc analyses of patients with medical devices, the regimen was associated with significant reductions in all-cause bloodstream infections and methicillin-resistant  Staphylococcus aureus (MRSA) or vancomycin-resistant enterococcus (VRE) clinical cultures.
PROVEN Publishes Study of Nursing Home Characteristics Associated With Implementation of an Advance Care Planning Video Intervention : The study suggests that ongoing support for and engagement with nursing home staff might be necessary in lower-quality nursing homes in order to implement successful pragmatic trials within these environments. I nvestigators of the Pragmatic Trial of Video Education in Nursing Homes (PROVEN), an NIH Collaboratory Demonstration Project, published these findings in the Journal of American Medical Directors Association .
Trial Spotlight
Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department–Initiated Buprenorphine for Opioid Use Disorder (EMBED): EMBED, a UG3 Collaboratory Demonstration Project, evaluates the effects of computerized clinical decision support on rates of emergency department–initiated buprenorphine and referral for ongoing medication-assisted treatment for patients with opioid use disorder. Last month, the project published its first manuscript in the Journal of Medical Internet Research. Watch a video interview about the study with co-principal investigator Dr. Ted Melnick and read more about EMBED.
Grand Rounds Roundup
Podcasts
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Upcoming Grand Rounds

March 29: ICD-Pieces: Lessons Learned in an Ongoing Trial (Miguel A. Vazquez, MD; George (Holt) Oliver, MD, PhD)

April 5: The ENGAGES Pragmatic Trial and the Power of Negative Thinking (Michael S. Avidan, MBBCh, FCA SA)

April 12: Development of Harmonized Outcome Measures for Use in Research and Clinical Practice (Richard Gliklich, MD; Michelle B. Leavy, MPH; Elise Berliner, PhD)

Featured in the Living Textbook
Because there are no standardized processes for ascertaining patient deaths in the United States, using death as an endpoint in pragmatic clinical trials (PCTs) is challenging . Death identification and adjudication may be especially complicated with PCTs that rely on data collected from the patient's electronic health record (EHR), medical claims, self-report, or medical devices. Using Death as an Endpoint , a new section of the Living Textbook, describes different death data sources, how to obtain information from them, and the pros and cons of each. Learn more in the Choosing and Specifying Endpoints and Outcomes chapter of the Living Textbook.