Congratulations to co-principal investigators Drs. Catalano, Kuklinski, and Sterling and the entire Guiding Good Choices for Health (GGC4H) study team for enrolling the first participant in this NIH Collaboratory Demonstration Project. GGC4H is a cluster randomized trial testing the feasibility and effectiveness of implementing Guiding Good Choices, a universal, evidence-based, anticipatory guidance curriculum for parents of early adolescents.
Johns Hopkins Berman Institute of Bioethics Postdoctoral Fellowship in Pragmatic Trials: The Johns Hopkins Berman Institute of Bioethics invites applications for a postdoctoral fellowship in the ethics and regulatory aspects of pragmatic clinical trials. The fellow will collaborate with Berman Institute faculty members and engage with the NIH Collaboratory Ethics and Regulatory Core and the Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) Resource Coordinating Center.
NIH Collaboratory-Supported Study Finds Baseline Covariate Imbalance Influences Treatment Effect Bias in Cluster Randomized Trials: The study, published in Contemporary Clinical Trials , found that treatment effect bias was proportional to the degree of baseline covariate imbalance and the covariate effect size .
Trial Spotlight
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (Nudge): More than half of patients with prescriptions for cardiovascular medications do not take their medications as prescribed. The Nudge study will use mobile phone text messages and an artificial intelligence chatbot to deliver behavioral "nudges" to patients to improve medication adherence. The study will access population-level pharmacy data in 3 integrated health care delivery systems to test the effectiveness of the nudges on adherence and outcomes among patients with chronic cardiovascular conditions who take medications to treat hypertension, atrial fibrillation, coronary artery disease, diabetes, or hyperlipidemia.

Read more about Nudge.
Grand Rounds Roundup

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Upcoming Grand Rounds

November 1: NIH Collaboratory: Looking Back and Looking Forward (Adrian F. Hernandez, MD, MHS; Lesley H. Curtis, PhD; Kevin Weinfurt, PhD)

November 8: Lumbar Imaging with Reporting of Epidemiology: Initial Results and Some Lessons Learned ( Jeffrey G. Jarvik MD MPH; Patrick Heagerty, PhD)

November 22: It’s Time to Learn From Patients Like Mine (Nigam H Shah, MBBS, PhD)

November 29: No presentation due to the Thanksgiving holiday
Featured in the Living Textbook
Ethics and regulatory issues can pose challenges to embedded pragmatic trials because of the unique nature of clinical research conducted in the setting of routine clinical care. Recently, six NIH Collaboratory study teams reviewed and updated their ethics and regulatory meeting minutes after transitioning from the planning to implementation phase. Find the meeting minutes from their discussions with the Ethics and Regulatory Core in the Living Textbook .