NRG Oncology Weekly Broadcast August 25, 2025

August 25, 2025

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PSC "Discuss With Us"

September Session

The next session of the Protocol Support Committee’s Discuss With Us series is scheduled for Wednesday, September 17, 2025 at 2pm ET and the topic is “Driving Quality Through Audit Best Practices.”

Learn more on our

"Discuss With Us" webpage

CLOSURE

GENITOURINARY

NRG-GU009: Closed to Accrual on August 18, 2025 (posted on CTSU)

AMENDMENTS

GENITOURINARY, GYNECOLOGIC, HEAD & NECK

The following protocol amendments, which are in response to NCI Action Letters, dated August 18, 2025, are posted with study-specific instructions on individual study pages on the CTSU website.

NCI Action Letter for CTEP-supported studies that involve nivolumab

NRG-GU012: Amendment 7; protocol version date: July 28, 2025

NRG-HN011: Amendment 4; protocol version date: August 4, 2025

NRG-GY025: Amendment 7; protocol version date: July 24, 2025 (temporarily closed to accrual)

NCI Action Letter for CTEP-supported studies that involve XL184 (cabozantinib)

NRG-GU012: Amendment 7; protocol version date: July 28, 2025

OTHER PROTOCOL NOTICES

1. ALL DISEASE SITES

NRG-GY022: Reminder: Actively Recruiting MALE Patients only Read More

2. BIOSPECIMEN BANK

Kit Shipments to Sites in Canada

Important information re: shipments of kits from BB Columbus to Sites in Canada. Please see the memorandum, dated August 18, 2025, posted on CTSU.

Printing Biospecimen Transmittal PDFs from Rave

Please note an effort is underway to clarify how to obtain a Biospecimen Transmittal PDF for submission to the NRG Oncology Biospecimen Bank. Read More

3. BRAIN

NRG-BN011: For all new and current participants receiving Lomustine in the US, orders should be directed to Azurity Pharmaceuticals. A Patient Assistance Program (PAP) form will need to be completed for each participant. Please see the memo posted on CTSU for further details.

NRG-BN011: The central lab, NYU Langone, will be closed on Monday September 1, 2025, for Labor Day. Please plan tissue shipments accordingly.

4. BREAST

NRG-BR009/OFSET: Site-Directed Video Tools

5. GENITOURINARY

NRG-GU015: Spanish approved Informed Consent posted to CTSU.

NRG-GU015: New study overview video interview is available on our YouTube channel.

6. GYNECOLOGIC

NRG-GY026: Reminder! Now accruing patients of all stages and all histologic subtypes of endometrial cancer.

NRG-GY031: Please note, there is an error in the section 4.2 table and the Biospecimen Collection and Submission Manual. The Part I PK collection is to be done on Cycle 1, Day 1, and Cycle 1, Day 8. This will be updated with the next amendment.

7. HEAD & NECK

NRG-HN008 - Reminder: please update treatment and AE data weekly. This is a Phase I trial and timely data submission is very important.

NRG-HN011: Attn Sites in Canada – Amendment 3 has been approved by Health Canada. The NOL and additional documents are posted on CTSU.

8. VTOC TRAINING

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on NRG-BN014, NRG-BR009, NRG-CC005, NRG-CC011, NRG-CC013, NRG-CC014, NRG-CC015, NRG-GU015 and NRG-HN014. Space is limited so register now and reserve your seat. The next webinar training is scheduled for September 10, 2025.

Investigator Brochure (IB) updates have been issued for the following studies:

DRUG NAME

PROTOCOL

*IB

Durvalumab

NRG-GY012

NRG-GY023

Palbociclib

EAY191-N5

*The current version of the Investigator Brochure Documents for Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI)-sponsored trials are available for access via the Cancer Therapy Evaluation Program (CTEP) Agent Inventory Management System (AURORA) application. Log-in using your Identity and Access Management (IAM) or ID.me credentials and provide the requested information to access the document.

Every site principal investigator is responsible for reviewing this document. The Investigator Brochure is for use by the site principal investigator and any study personnel under his/her supervision who need to know the contents for the conduct of a clinical trial, including Institutional Review Board(s) or Independent Ethics Committee(s).

1. PSC “Discuss With Us” – September Session

Use this link or the QR code on the right to register today! Once you register, you will be given a calendar invite for all future sessions. Visit the Discuss With Us page on the NRG Oncology website for session recordings, slide presentations, and information about upcoming sessions.

2. Reminder: Labor Day Holiday Closures

Please refer to the memorandum posted on CTSU for information about NRG Oncology Operations offices, SDMCs, Biospecimen Banks, and McKesson Research Services closures and shipping information for the upcoming Labor Day holiday on Monday, September 1, 2025.

3. NCTN CTMB Audit Guidelines Update

Updated NCTN CTMB Audit Guidelines (August 15, 2025), along with a summary of changes, and can be found on the CTEP-Supported Clinical Trials Site Focused Resources pages: Network Clinical Trials Quality Assurance - NCI. The August 15, 2025, version of the guidelines is to be used immediately. Please review the summary of changes document as a number of updates have been made. One key change is the introduction of a new category to the Patient Case audit component. The category “Correlative Studies, Tests, and Procedures” has been added and some of the deficiencies that were previously included under the “General Data Management Quality” category have been moved to this new category. The NRG Oncology Quality Assurance resources located on the NRG Oncology website are being revised to reflect the updated guidelines. Sites will be notified via broadcast when the revised resources become available.

4. NRG Health Care Access Fellowship – Call for Applications

NRG Oncology is currently seeking applications for the NRG Care Access Fellowship. This program trains selected early-stage investigators in the NRG Oncology system by means of a structured mentorship experience, with particular emphasis given to the recruitment of researchers with a passion for improving health care access. Our vision is to have at least one scholar for every disease site we study. The deadline for applications is September 19, 2025, and awards will be announced in November. Additional information about the program is posted on the NRG Oncology website. Fellowship Start Date: January 1, 2026

5. NRG Oncology Current Committee Leadership Openings

Medical Oncologist Vice Chair, Head and Neck Cancer Committee

Applications DUE September 1, 2025 - Read more & How to Apply

Medical Oncologist Vice Chair, Lung Cancer Committee

Applications DUE September 1, 2025 - Read more & How to Apply

Chair, Ancillary Projects Committee

Applications DUE September 19, 2025 - Read more & How to Apply

Chair, Brain Tumor Committee

Applications DUE September 19, 2025 - Read more & How to Apply

Chair, Breast Cancer Committee

Applications DUE September 19, 2025 - Read more & How to Apply

Chair, Patient-Centered Research (PCOR) Committee

Applications DUE September 19, 2025 - Read more & How to Apply

Chair, Medical Physics Subcommittee

Applications DUE September 19, 2025 - Read more & How to Apply

6. REGISTER TODAY! Radiation Oncology Educational Webinar Series – Next Session: “Radiation Therapy Benign Conditions”

The next webinar for the Radiation Oncology Educational Webinar Series will be held on Wednesday, September 17^th from 4:30-5:30pm ET. This is a CME event. Featured presentations include “Stereotactic Radiosurgery for Benign Brain Indications” and “Radiation Therapy for Benign Musculoskeletal Conditions”. Register and earn CME

Please review the Program Materials for this session pertaining to CME credits and disclosures: http://bit.ly/4lyfXub

7. RTOG Foundation New Session at ASTRO 2025

Attending ASTRO 2025 and want to learn more about RTOG Foundation and NRG Oncology? RTOG Foundation will be holding a brief introduction and networking session in the Early Career and Mentoring Lounge (North Lobby) from 8:00-8:30am Monday, September 29, 2025. We hope to see you there!

8. NRG Member Information Form

We are excited to introduce the NRG Member Information Data Collection Initiative that will allow us to create a comprehensive member database, enabling us to better understand and serve our members. Your information will be kept secure and confidential, ensuring that your privacy is always protected. All members are encouraged to complete the form or indicate that they wish to opt out of this data collection initiative.

Scan the QR code below or click this link to access the form.

Questions? Read more here

NRG Oncology is pleased to report the scientific articles that appeared during the previous week. This publications report includes links, when available, to the article, PubMed abstract, or association abstract.

PUBLISHED ARTICLES

Zumsteg ZS, Luu M, Fortpied C, Jang JK, Chen MM, Mallen-St Clair J, Walgama E, Le QT, Machtay M, Tribius S, Forastiere A, Wong S, Ozsahin EM, Gregoire V, Vermorken JB, Ho AS, Yom SS. Re-examining post-operative chemoradiotherapy in head and neck cancer: an updated long-term combined analysis of RTOG 9501/EORTC 22931. Ann Oncol. 2025 Jul 16:S0923-7534(25)00853-1. doi: 10.1016/j.annonc.2025.07.004. Epub ahead of print. PMID: 40680992. Read more.

Please note the following upcoming meetings and abstract submission deadlines

UPCOMING MEETINGS:

AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Sep 18-21, 2025; Baltimore, MD

American Society for Radiation Oncology (ASTRO); Sep 28-Oct 1, 2025; San Francisco, CA

Canadian Association of Radiation Oncology (CARO); Sep 10-13, 2025; Calgary, AB

PA Breast Cancer Coalition (PBCC); Oct 15, 2025; Harrisburg, PA

International Society for Quality-of-Life Research (ISOQOL); Oct 22-25, 2025; Milwaukee, WI

Radiological Society of North America (RSNA); Nov 30-Dec 4, 2025; Chicago, IL

Society for Immunotherapy of Cancer (SITC); Nov 5-9, 2025; National Harbor, MD

UPCOMING ABSTRACT SUBMISSION DEADLINES:

American Association for Cancer Research (AACR); Apr 17-22, 2026; San Diego, CA; Due to publications committee Nov 4, 2025; Submission deadline Nov 18, 2025; LBA and Clinical Trials Jan 6, 2026

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; Oct 22-26, 2025; Boston, MA; LBA and Clinical Trials Sep 10, 2025, 1:00 pm ET

American Society of Clinical Oncology (ASCO); May 29-Jun 2, 2026; Chicago, IL; Due to publications committee Jan 13, 2026; Submission deadline Jan 27, 2026, 11:59 pm ET; LBA Mar 9, 2026, 12:00 pm ET (placeholder required)

American Society of Clinical Oncology (ASCO) GI; Jan 8-10, 2026; San Francisco, CA; Due to publications committee Aug 26, 2025; Submission deadline Sep 9, 2025, 11:59 pm ET; LBA Oct 9, 2025, 12:00 pm ET

American Society of Colon and Rectal Surgeons (ASCRS); May 9-12, 2026; Tampa, FL; Due to publications committee Sep 30, 2025; Submission deadline Oct 14, 2025, 11:59 pm ET; LBA and Clinical Trials Jan 28, 2026

European Society for Medical Oncology (ESMO); Oct 17-21, 2025; Berlin, Germany; LBA Sep 9, 2025, 21:00 CET (placeholder required)

European Society of Gynaecological Oncology (ESGO); Feb 26-Mar 1, 2026; Copenhagen, Denmark; Due to publications committee Oct 17, 2025; Submission deadline Oct 31, 2025, 23:59 CET; LBA Jan 15, 2026

European Society for Radiotherapy and Oncology (ESTRO); May 15-19, 2026; Stockholm, Sweden; Due to publications committee Oct 29, 2025; Submission deadline Nov 12, 2025; LBA Apr 8, 2026

International Gynecologic Cancer Society (IGCS); Nov 5-7, 2025; Cape Town, South Africa; LBA Sep 29, 2025 (placeholder required)

San Antonio Breast Cancer Symposium (SABCS); Dec 9-12, 2025; San Antonio, TX; LBA Sep 30, 2025, 11:59 pm CT

Society for Neuro-Oncology (SNO); Nov 19-23, 2025; Honolulu, HI; LBA Sep 2, 2025, 5:00 pm ET

SSO - Advanced Cancer Therapies; Feb 14-16, 2026; Fort Lauderdale, FL; Due to publications committee Oct 6, 2025; Submission deadline Oct 20, 2025

Society of Urologic Oncology (SUO); Dec 2-5, 2025; Dallas, TX; LBA Oct 1, 2025