January 13, 2025

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NRG Oncology Winter Meeting Registration

There is still time to register to join us in Phoenix, AZ for the NRG2025 Winter Meeting. The meeting will be held in-person, January 16-18, 2025, with select virtual sessions being held January 6-14, 2025.

More information | Agenda | Register

Winter 2025 Symposium – Designing and Implementing Pragmatic Clinical Trials in Oncology

A new type of trial design is coming to NRG Oncology. This important symposium will be held in-person in Phoenix on Thursday, January 16, 2025 from 8am – 12pm MT. There will also be a virtual option. The symposium will highlight the value of pragmatic clinical trials across oncology and include examples of trials in lung, breast, and gynecologic cancers.

More information  | Agenda | Register

NRG NCORP Bootcamp – January 16, 2025

NRG NCORP will host a Bootcamp on January 16, 2025, 8-10amMT during the NRG Oncology Winter Meeting in Phoenix. This session will provide an overview of the NRG Oncology NCORP Research Base with a specific focus on developing and designing an NCORP concept. Committee chairs will highlight priorities in Cancer Prevention and Control (CPC), Cancer Care Delivery Research (CCDR), and Health Disparities Research (HDR). Dr. Pugh will discuss statistical design considerations and Dr. Crane will discuss how to run an R01 utilizing the NCORP process. Flyer | Register

NRG Oncology Protocol Support Committee – Educational Sessions

Please be sure to sign up to attend the PSC Nurse/CRA Sessions being held during the NRG Oncology Winter Meeting in Phoenix. The Protocol Support Committee (PSC) will offer Introduction to Clinical Trials: Principles of NRG Oncology Clinical Trial Management for Nurse/CRAs on Thursday, January 16. Morning presentations and afternoon discussion sessions will be presented in-person and virtually. The Continuing Education Session for Nurse/CRAs on Friday, January 17 will be held virtually and in-person and are for both seasoned and new research staff. Please refer to the posted agendas (login required) and flyers for more details about the PSC programing offered during #NRG2025.

Scientific Session – January 17, 2025

We are pleased to announce the #NRG2025 Scientific Session. During this session, the second NRG Oncology Gold Medal will be awarded, and NRG Oncology researchers will present Unexpected Triumphs: Finding Value in the Unforeseen. View the session flyer here.

Stay Connected during #NRG2025

Are you attending the #NRG2025 Winter meeting - either virtual or in-person and have a social media account? During the sessions, use the hashtag #NRG2025 to be a part of the conversation!

AMENDMENTS

LUNG

NRG-LU008: Attn Sites in Canada: Amendment 2 has been approved by Health Canada. The documents are posted on CTSU. Please remember to complete the Protocol Signature Page and CTSI and submit via the CTSU regulatory submission portal.

FORM UPDATES

LUNG

NRG-LU008: The OPEN Eligibility Checklist, Blank Rave Forms Packet, Data Submission Table and PRO-CTCAE Questionnaire documents have been updated. The updated versions are posted on CTSU. Please begin using these new forms and/or documents immediately.

OTHER PROTOCOL NOTICES

1. ALL DISEASE SITES

NRG-GY022: Reminder: Actively Recruiting MALE Patients only Read More

2. BIOSPECIMEN BANKS

Printing Biospecimen Transmittal PDFs from Rave

Please note an effort is underway to clarify how to obtain a Biospecimen Transmittal PDF for submission to the NRG Oncology Biospecimen Bank. Read More

3. CANCER PREVENTION & CONTROL

NRG-CC005/FORTE: FORTE Fridays newsletter

NRG-CC010: The study is open to NRG sites in Japan and South Korea. The optional biospecimen collection does not apply to sites participating in these countries.

4. GENITOURINARY

NRG-GU011: Reminder! This phase II trial for patients with Oligometastatic Prostate Cancer is open to enrollment. The study is open to all NCTN member sites in the U.S and Canada. Please help us enroll. Protocol documents are posted on CTSU.

5. GYNECOLOGIC

NRG-GY026: Please note, the post-chemo cfDNA Whole Blood (WB03) should only be collected if the Pre-Treatment cfDNA Whole Blood (WB01) was collected.

NRG-GY031: Please note, there is an error in the section 4.2 table and the Biospecimen Collection and Submission Manual. The Part I PK collection is to be done on Cycle 1, Day 1, and Cycle 1, Day 8. This will be updated with the next amendment.

6. HEAD & NECK

NRG-HN008

Reminder: please update treatment and AE data weekly. This is a Phase I trial and timely data submission is very important.

NRG-HN014: Patient Study Web Page is available on the NRG website and Participant Brochure is available on the CTSU website (CIRB Approved Documents >Support Documents).

7. LUNG

NRG-LU008: Reopened to accrual on January 7, 2025. See Study Memorandum dated January 7, 2025 (posted to CTSU).

8. VTOC TRAINING

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on NRG-HN001, NRG-HN002, NRG-CC003, NRG-CC005, NRG-BR009, NRG-BN014, NRG-CC011, NRG-CC013, NRG-HN014, and NRG/SWOG S1914. Space is limited so register now and reserve your seat. The next webinar training is scheduled for February 12, 2025.

DRUG SAFETY AND INVESTIGATOR’S BROCHURE (IB) UPDATES

Drug Safety and Investigator’s Brochure updates have been issued for the following studies:

*The current version of the Investigator Brochure Documents for Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI)-sponsored trials are available for access via the Cancer Therapy Evaluation Program (CTEP) Agent Inventory Management System (AURORA) application. Log-in using your Identity and Access Management (IAM) or ID.me credentials and provide the requested information to access the document.

Every site principal investigator is responsible for reviewing this document. The Investigator Brochure is for use by the site principal investigator and any study personnel under his/her supervision who need to know the contents for the conduct of a clinical trial, including Institutional Review Board(s) or Independent Ethics Committee(s).

1. Translational Science Committee Soliciting Pilot Projects for Inclusion in the NRG UG1 Translational Science Center Application

The NRG Oncology Translational Science Committee is soliciting one-page proposals (with Specific Aims) for pilot projects to incorporate into their “Network Group Integrated Translational Science Center” application due in February 2025. More information available here.

2. NRG Oncology Seeking Candidate for Deputy NCORP PI Role

We are seeking nominations for the position of Deputy NCORP PI. The NCI Community Oncology Research Program (NCORP) brings cancer research studies and results to patients in a variety of community settings across the United States. NRG is one of seven NCORP research bases and one of only four focused on adults with cancer. The focus of the NRG NCORP is on cancer control, cancer prevention and cancer care delivery. Patient reported outcomes and health disparities are cross-cutting themes incorporated into most NCORP protocols as well as NRG treatment trials. The deadline for the application submission is February 14, 2025. Read more

3. NRG Oncology Seeking Candidate for Cancer Control Committee Chair Role

We are seeking nominations for the position of Chair of the NRG NCORP Cancer Control Committee. Candidates for this position should have an active program of funded research and publications focused on the NRG cancer control priorities of improvement or delay in decline of neurocognitive function, reducing gender specific symptoms such as lymphedema and sexual function, and testing therapeutic delivery modifications to improve QoL and cost-effectiveness in localized cancers while maintaining efficacy. Candidates should have a track record of mentorship and a willingness to provide timely consultation to members and liaisons of NRG committees as concepts and protocols are being developed. In addition to leading the NRG Cancer Control Committee, this candidate will also serve as a co-chair of the Cancer Prevention and Control (CPC) Committee. This individual will work closely with the CPC on the priorities of the overall committee. The deadline for the application submission is February 14, 2025. Read more

4. AACR Special Conference in Cancer Research

The AACR Special Conference Meeting will be held January 26-29, 2025 in San Deigo. This is the first meeting focusing on radiation and targeted therapy. The program has many oral and poster presentation opportunities from proffered abstracts in addition to presentations from experts in the field. Please encourage your faculty and trainees to submit abstracts and register for this meeting. Abstract submission is now opened. However, abstract submission is not required for attendance. Looking forward to seeing many of you in San Diego! Registration opens soon, learn more on the AACR website.

5. NRG Member Demographics Data Collection Initiative

We are excited to introduce the NRG Member Demographics Data Collection Initiative that will allow us to create a comprehensive member database, enabling us to better understand and serve our members. Your information will be kept secure and confidential, ensuring that your privacy is always protected. All members are encouraged to complete the form or indicate that they wish to opt out of this data collection initiative. 

Scan the QR code below or click this link to access the form. 

Questions? Read more here

6. MLK Day Holiday Closures

Please note the following NRG Oncology locations will be closed for the Martin Luther King, Jr. holiday on Monday, January 20, 2025. All locations resume regular business hours on Tuesday, January 21, 2025.



• Philadelphia East Operations Center
• Philadelphia West Operations Center
• Pittsburgh Operations Center
• Buffalo SDMC office
• Philadelphia SDMC
• Pittsburgh SDMC
• Biospecimen Bank – San Francisco
• Biospecimen Bank – Pittsburgh

McKesson’s Clinical Research Services will also be closed on Monday, January 20. The NRG Biospecimen Bank in Columbus will be open on Monday, January 20, and will accept specimens as usual.

Please refer to the memorandum posted on the CTSU website (under LPO updates) for additional information related to shipping instructions to the Biospecimen Bank locations.

NRG Oncology is pleased to report the following scientific articles that have appeared during the previous week as well as an abstract accepted for presentation at the ASCO Genitourinary Cancers Symposium.

This publications report includes links, when available, to the article, PubMed abstract, or association abstract.

ACCEPTED ABSTRACTS

Hoffman KE, Kamran SC, Ryu HM, Proudfoot JA, Davicioni E, Nguyen PL, Pugh SL, Spratt DE, Michalski JM, Parliament MB, Dayes IS, Correa RJ, Robertson JM, Gore EM, Doncals DE, Vigneault E, Souhami L, Feng FY, Tran PT, Zhao SG. PORTOS gene signature predicts risk of adverse events after dose-escalated vs. lower-dose prostate radiation therapy in NRG-RTOG 0126. ASCO GU. 2/15/2025. Poster Presentation.

PUBLISHED ARTICLES

Coen JJ, Rodgers JP, Saylor PJ, Lee CT, Wu CL, Parker W, Lautenschlaeger T, Zietman AL, Efstathiou J, Jani AB, Kucuk O, Souhami L, Pugh SL, Sandler HM, Shipley WU. Long-Term Results of Bladder Preservation With Twice-Daily Radiation Plus 5-Fluorouracil/Cisplatin or Daily Radiation Plus Gemcitabine for Muscle-Invasive Bladder Cancer-Updated Report of NRG/RTOG 0712: A Randomized Phase 2 Trial. Int J Radiat Oncol Biol Phys. 2025 Jan 1;121(1):153-161. doi: 10.1016/j.ijrobp.2024.08.007. Epub 2024 Aug 13. PMID: 39147209. Read more

Paganetti H, Simone CB 2nd, Bosch WR, Haas-Kogan D, Kirsch DG, Li H, Liang X, Liu W, Mahajan A, Story MD, Taylor PA, Willers H, Xiao Y, Buchsbaum JC. NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy. Int J Radiat Oncol Biol Phys. 2025 Jan 1;121(1):202-217. doi: 10.1016/j.ijrobp.2024.07.2152. Epub 2024 Jul 25. PMID: 39059509; PMCID: PMC11646189. Read more

Pennington KP, Pugh SL, Huh W, Walker JL, Jewell E, Havrilesky LJ, Carter J, Muller CY, Drapkin R, Lankes HA, Castellano T, Zamorano AS, Blank SV, Kachnic LA. Optimization of Timing for Risk-Reducing Salpingectomy and Oophorectomy. Obstet Gynecol. 2025 Jan 1;145(1):21-30. doi: 10.1097/AOG.0000000000005781. Epub 2024 Nov 7. PMID: 39509704; PMCID: PMC11637911. Read more

Mayadev J, Zamarin D, Deng W, Lankes HA, Pesci G, Kim H, Chino JP, Banbury B, Sherry N, Sharon E, Ghamande SA, Ferguson C, Mell L, Holman L, Mathews C, O'Malley D, Olawaiye A, Hopp E, Leath C 3rd, Copeland L, Mannel R, O'Cearbhaill R, Aghajanian C, Schilder RJ. Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial. Nat Commun. 2025 Jan 9;16(1):553. doi: 10.1038/s41467-024-55200-2. PMID: 39788967. Read more

Please note the following upcoming meetings and abstract submission deadlines

UPCOMING MEETINGS:

American Association for Thoracic Surgery (AATS); May 2-5, 2025; Seattle, WA

American Head & Neck Society (AHNS); May 14-15, 2025; New Orleans, LA

American Radium Society (ARS) Annual Meeting; Apr 3-6, 2025; Seattle, WA

American Society of Clinical Oncology (ASCO) GI; Jan 23-25, 2025; San Francisco, CA

American Society of Clinical Oncology (ASCO) GU; Feb 13-15, 2025; San Francisco, CA

American Surgical Association (ASA); Apr 24-26, 2025; San Diego, CA

Miami Breast Cancer Conference; Mar 6-9, 2025; Miami, FL

Society for Clinical Trials (SCT); May 18-21, 2025; Vancouver, BC

Society for Gynecologic Oncology (SGO); Mar 14-17, 2025; Seattle, WA

Society of Surgical Oncology (SSO) Annual Meeting; Mar 27-29, 2025; Tampa, FL

SSO – Advanced Cancer Therapies; Feb 14-17, 2025; Scottsdale, AZ

St. Gallen Breast Cancer Conference; Mar 12-15, 2025; Vienna Austria

UPCOMING ABSTRACT SUBMISSION DEADLINES:

American Association for Cancer Research (AACR); Apr 25-30, 2025; Chicago, IL; LBA and Clinical Trials Jan 16, 2025, 11:59 pm ET

American Brachytherapy Society (ABS); Jun 18-21, 2025; Nashville, TN; Due to publications committee Jan 21, 2025; Submission deadline Feb 4, 2025, 6:00 pm PT

American College of Radiology (ACR); May 3-7, 2025; Washington, DC; Due to publications committee Jan 13, 2025; Submission deadline Jan 27, 2025, 11:59 pm ET

American Society of Breast Surgeons (ASBrS); Apr 30-May 4, 2025; Las Vegas, NV; LBA Feb 5, 2025 (placeholder required)

American Society of Clinical Oncology (ASCO); May 30-Jun 3, 2025; Chicago, IL; Due to publications committee Jan 14, 2025; Submission deadline Jan 28, 2025; LBA Mar 5, 2025 (placeholder required)

American Society of Colon and Rectal Surgeons (ASCRS); May 11-14, 2025; San Diego, CA; LBA and Clinical Trials Jan 29, 2025, 11:59 pm ET

American Society for Radiation Oncology (ASTRO); Sep 28-Oct 1, 2025; San Francisco, CA; Due to publications committee Feb 11, 2025; Submission deadline Feb 25, 2025, 11:59 pm PT; LBA Jul 10, 2025, 11:59 pm PT

Canadian Association of Radiation Oncology (CARO); Sep 10-13, 2025; Calgary, AB; Due to publications committee Feb 6, 2025; Submission deadline Feb 20, 2025

European Society of Gynaecological Oncology (ESGO); Feb 20-23, 2025; Rome, Italy; LBA Jan 15, 2025 (placeholder required)

European Society for Medical Oncology (ESMO); Oct 17-21, 2025; Berlin, Germany; Due to publications committee Apr 25, 2025; Submission deadline May 13, 2025, 21:00 CET; LBA Sep 9, 2025, 21:00 CET (placeholder required)

ESMO Breast Cancer; May 14-16, 2025; Munich, Germany; Due to publications committee Jan 28, 2025; Submission deadline Feb 11, 2025, 21:00 CET; LBA Apr 15, 2025, 21:00 CET (placeholder required)

ESMO Gynaecological Cancers; Jun 19-21, 2025; Vienna, Austria; Due to publications committee Mar 18, 2025; Submission deadline Apr 1, 2025, 21:00 CET

European Society for Radiotherapy and Oncology (ESTRO); May 2-6, 2025; Vienna, Austria; LBA Mar 19, 2025

International Society for Quality-of-Life Research (ISOQOL); Oct 22-25, 2025; Milwaukee, WI; Due to publications committee Mar 25, 2025; Submission deadline Apr 7, 2025