NRG Oncology Weekly Broadcast October 20, 2025

October 20, 2025

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The NRG Oncology Podcast – New Episode!

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Reminder, the following clinical trials are open to enrollment. Please continue to review your patient population and discuss enrollment opportunities with your clinical teams. All protocol related documents are posted on CTSU.

NRG-BR009/OFSET is a Phase III randomized trial now enrolling premenopausal women with pN0-1, ER-positive and HER2-negative breast cancer.

NRG-GU008 is recruiting patients who have node-positive prostate cancer and need more treatment after prostatectomy.

NRG-GU011 is open to enrollment for patients with oligometastatic prostate cancer – only 40 patients to go! Please help us complete this trial.

NRG-GU012: Reminder, the maximum number of accrual of non-clear cell patients is 48. Currently, there are 11 patients registered who have this type of histology. Please continue to screen patients with this histology.

NRG-GY026 is now accruing patients of all stages and all histologic subtypes of endometrial cancer.

CLOSURE

BRAIN

NRG-BN012: closure to accrual at 5 PM ET Tuesday October 21, 2025, because it has reached its accrual target. Patients may be entered onto the study until 5 PM ET October 21.

FORM UPDATES

CANCER CARE DELIVERY RESEARCH

NRG-CC012CD: An updated Eligible List of Agents, version date October 15, 2025, is posted on CTSU.

SUMMARY OF RESEARCH RESULTS FOR PATIENTS

CANCER PREVENTION AND CONTROL

RTOG 0631: A summary of research results is available on the NRG Patient Study Web Page. Sites, please share the summary of research results with study participants.

GENITOURINARY

RTOG-0232: A summary of research results is available on the NRG Patient Study Web Page and the CTSU website. Sites, please share the summary of research results with study participants.

OTHER PROTOCOL NOTICES

1. ALL DISEASE SITES

NRG-GY022: Reminder: Actively Recruiting MALE Patients only. Read More

2. BIOSPECIMEN BANK

Printing Biospecimen Transmittal PDFs from Rave

Please note an effort is underway to clarify how to obtain a Biospecimen Transmittal PDF for submission to the NRG Oncology Biospecimen Bank. Read More

Kit Shipments to Sites in Canada

Important information re: shipments of kits from BB Columbus to Sites in Canada. Please see the memorandum, dated August 18, 2025, posted on CTSU.

3. BRAIN

NRG-BN011: Beginning September 12, 2025, please use the updated NRG-BN011 Gleostine® (lomustine) Clinical Trial Order form (posted on CTSU). The prescription form is no longer required and PHI should not be sent to Azurity. An updated memo is also posted on CTSU. Please update pharmacy staff as well.

4. CANCER PREVENTION & CONTROL

NRG-CC005/FORTE: Clinical research professionals can sign up for NRG Oncology Weekly Broadcasts to receive monthly FORTE Fridays updates directly to your inbox (click here).

5. GYNECOLOGIC

NRG-GY031: Please note, there is an error in the section 4.2 table and the Biospecimen Collection and Submission Manual. The Part I PK collection is to be done on Cycle 1, Day 1, and Cycle 1, Day 8. This will be updated with the next amendment.

6. HEAD & NECK

NRG-HN008

Reminder: please update treatment and AE data weekly. This is a Phase I trial and timely data submission is very important.

7. VTOC TRAINING

For all NRG studies that use VTOC (Vision Tree Optimal Care): It has come to our attention that although Vision Tree has whitelisted their domain, Yahoo and AT&T have strong filters for spam that have been prohibiting participants from getting their emails. Please ask participants to 1) save the email address (fasttrack@optimalcare.com) as a contact or 2) suggest an alternative email (i.e. gmail is a successful alternative) when setting up their accounts.

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on NRG-BN014, NRG-BR009, NRG-CC005, NRG-CC011, NRG-CC013, NRG-CC014, NRG-CC015, NRG-GI011, NRG-GI012, NRG-GU015, and NRG-HN014. Space is limited so register now and reserve your seat. The next webinar training is scheduled for November 12, 2025.

DRUG NAME	PROTOCOL	WEBSITE FOR SAFETY UPDATES	IB*
Atezolizumab	NRG-BN010 NRG-GI004 NRG-GY009 NRG-LU005 NRG-LU002 NRG-LU007 RTOG-1216	CTSU CTSU CTSU CTSU CTSU CTSU CTSU
Pertuzumab, trastuzumab, and hyaluronidase-zzxf (PHESGO)	NRG-GY026		X
Trastuzumab emtansine	NRG-BN010 NRG-HN010		X

*The current version of the Investigator Brochure Documents for Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI)-sponsored trials are available for access via the Cancer Therapy Evaluation Program (CTEP) Agent Inventory Management System (AURORA) application. Log-in using your Identity and Access Management (IAM) or ID.me credentials and provide the requested information to access the document.

Every site principal investigator is responsible for reviewing this document. The Investigator Brochure is for use by the site principal investigator and any study personnel under his/her supervision who need to know the contents for the conduct of a clinical trial, including Institutional Review Board(s) or Independent Ethics Committee(s).

1. The NRG Oncology Podcast – New Episode!

In our latest episode, we talk with NRG NCORP Principal Investigator, Deborah Bruner, PhD, RN, FAAN, about all things NCORP, the importance of reaching the community in research, and the major role Advanced Practice Providers play in helping us achieve that goal. http://NRGOncology.org/Podcast

2. NRG Oncology Currents Newsletter

Our October Newsletter edition is available! Read about our Breast Cancer Awareness Features, a special study highlight for ComboMATCH N5, current trials on deck, and more! Check it out here.

3. NRG Oncology Winter 2026 Travel Awards

NRG Oncology seeks to support robust participation in our semiannual meetings through the provision of travel support. Current priorities for travel awards include young investigators, study chairs and engaged study champions, active committee members, member institution PI’s, and clinical research professionals who are actively engaged with NRG Oncology committees. Our partnering foundations, RTOG Foundation, NSABP Foundation, and GOG Foundation may also consider supporting requests through this mechanism.

The application deadline is October 31, 2025 at 11:59 PM ET. Awardees will be notified by November 14, 2025. More information | Apply for NRG Travel Award

4. NCORP Pilot Grant – Call for Letter of Intent (LOI)

NRG NCORP is soliciting LOIs in preparation for the next NCORP pilot grant RFA.

Anyone interested in applying must submit a Letter of Intent (LOI) by October 24, 2025. Click here to download the form
The request for funding application (RFA) for NCORP pilot projects will be released in Spring 2026; however, interested applicants must submit a LOI.
NCORP committee chairs will review LOIs and select those best aligned with committee goals, NCORP priorities and feasible.
Selected investigators will be notified and invited to attend a workshop the NRG Winter Meeting in San Francisco, CA; January 22-24, 2026

For more information, slides are available for download here.

5. NRG-GI008 (CIRCULATE-NORTH AMERICA) Study Webinar

The NRG Clinical Coordinating Department (CCD) is planning webinars for the NRG-GI008 trial on October 30 and November 4. The GI008 Principal Investigators, NRG Oncology staff, and staff from Natera will present during the webinars. An overview of the protocol will be given, key protocol logistics, and the ctDNA testing process will be discussed. There will also be time for questions and answers.

These webinars are intended for PIs and research staff who currently have NRG-GI008 open at their site, as well as those interested in opening GI008 at their site in the future. To register to attend one of the sessions please click here. If you have questions about the webinars, please contact the Clinical Coordinating Department at ccdPGH@NRGOncology.org.

6. NRG-GU015 (ARCHER) Study Webinar

Save the date and register for our webinar for the NRG-GU015 “ARCHER” study assessing shorter duration radiation therapy for patients receiving chemotherapy for bladder cancer. The webinar will be held on Friday, December 12, 2025 from 1:00-2:00 PM ET (10:00-11:00 AM PT) and will be hosted by the study Principal Investigators Dr. Scott Delacroix Jr. and Dr. Himanshu Nagar. Register here

7. PSC “Discuss With Us” – November Session

The next session of the Protocol Support Committee’s Discuss With Us series is scheduled for Wednesday, November 19, 2025 at 2pm ET and the topic is “AEs & SAEs Let’s Talk.”

Please note: the recording and PROs Q&A document from the October 2025 session are now posted on the Discuss With Us page on the NRG Oncology website. Additionally, beginning with the November session, this program is now approved by the Virginia Nurses Association to award continuing education nursing contact hours. The Virginia Nurses Association is accredited as an approver of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

Use this link or the QR code to register today! You only need to register once, and you will then receive calendar invites for all future sessions. Visit the Discuss With Us page on the NRG Oncology website for session recordings, slide presentations, and information about upcoming sessions.

8. NRG Oncology Current Committee Leadership Openings

Vice Chair, Surgical Oncologist Brain Tumor Committee
Applications DUE October 20, 2025 - Read more & How to Apply

Vice Chair, Translational Science Brain Tumor Committee
Applications DUE October 20, 2025 - Read more & How to Apply

Vice Chair, Neuro-Oncologist/Medical Oncologist Brain Tumor Committee
Applications DUE October 20, 2025 - Read more & How to Apply

Vice Chair, Radiation Oncologist Breast Cancer Committee
Applications DUE October 20, 2025 - Read more & How to Apply

Vice Chair, Translational Science Committee
Applications DUE October 20, 2025 - Read more & How to Apply

Vice Chair, Surgical Oncology Committee
Applications DUE October 23, 2025 - Read more & How to Apply

Chair, Protocol Operations Management Committee
Applications DUE October 23, 2025 - Read more & How to Apply

Vice Chair, Publications Committee
Applications DUE October 23, 2025 - Read more & How to Apply

Medical Oncologist Vice Chair, Genitourinary Committee
Applications DUE October 23, 2025 - Read more & How to Apply

Chair, Medical Physics Subcommittee
Applications DUE October 31, 2025 - Read more & How to Apply

Chair, Medical Oncology Committee
Applications DUE October 31, 2025 - Read more & How to Apply

9. NRG Member Information Form

We are excited to introduce the NRG Member Information Data Collection Initiative that will allow us to create a comprehensive member database, enabling us to better understand and serve our members. Your information will be kept secure and confidential, ensuring that your privacy is always protected. All members are encouraged to complete the form or indicate that they wish to opt out of this data collection initiative.

Scan the QR code below or click this link to access the form.

Questions? Read more here

PUBLICATIONS REMINDERS

Author Contact Information

All Authors are advised to keep their contact information up to date either via the NCI Clinical Trials Support Unit (CTSU) portal (https://ctsu.cancer.gov/) or by notifying NRG-Publications@NRGOncology.org directly.

NRG Oncology is pleased to report the following scientific articles that appeared during the previous week as well as abstracts accepted for presentation at medical conferences.

This publications report includes links, when available, to the article, PubMed abstract, or association abstract.

ACCEPTED ABSTRACTS

Bixel, Kristin Leigh; Sill, Michael W; Haight, Paulina; Beffa, Lindsey; Moore, Richard G; Musa, Fernanda B; Holman, Laura L; Schilder, Russell; Gill, Sarah; Girda, Eugenia; Lokich, Elizabeth; Vicus, Danielle; Kavecansky, Juraj; Hinchclilff, Emily; Leath, Charles A; Lele, Sashikant B; Backes, Floor; Fader, Amanda N; Welch, Stephen; Eskander, Ramez N: Low neutrophil-to-lymphocyte ratio is associated with improved progression free survival in patients with advanced or recurrent endometrial cancer: an ancillary analysis of NRG-GY018. Featured Poster.

Secord, Angeles Alvarez; Sill, Michael W; Lankes, Heather A; Birrer, Michael J; Monk, Bradley J.; Liu, Yingmiao; Starr, Mark D; Brady, Chris; Leitao, Mario; Ramondetta, Lois M; Clair, Kiran; Newton, Meredith; Guntupalli, Saketh; Richardson, Debra; DiSilvestro, Paul A; Cantuaria, Guilherme; Leath, Charles A III; Billingsley, Caroline C; McDonald, Megan E; Lea, Jayanthi; Ueland, Frederick R; Chambers, Laura; Tewari, Krishnansu S; Nixon, Andrew B: Predictive Blood-Based Biomarkers In Cervical Cancer Patients Treated With Paclitaxel-Based Chemotherapy With Or Without Bevacizumab: Results From GOG-0240. Oral Presentation.

PUBLISHED ARTICLES

Chan E, Pugh SL, Simko JP, Feng F, Shipley WU, Lukka HR, Bahary JP, Pisansky TM, Zeitzer KL, Gore E, Efstathiou JA, Rosenthal SA, Balogh AG, Lovett RD, Wong A, Dess RT, McGinnis LS, Kuettel M, DeMora L, Sandler HM. Prognostic Impact of Lymph Node Yield in a Phase III Clinical Trial (NRG/RTOG 9601) of Prostate Cancer Patients Treated With Salvage Radiation Following Prostatectomy. Prostate. 2025 Oct;85(14):1315-1322. doi: 10.1002/pros.70018. Epub 2025 Jul 21. PMID: 40686005; PMCID: PMC12366761. Read more

Please note the following upcoming meetings and abstract submission deadlines

UPCOMING MEETINGS

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; Oct 22-26, 2025; Boston, MA

European Society for Medical Oncology (ESMO); Oct 17-21, 2025; Berlin, Germany

International Gynecologic Cancer Society (IGCS); Nov 5-7, 2025; Cape Town, South Africa

International Society for Quality-of-Life Research (ISOQOL); Oct 22-25, 2025; Milwaukee, WI

PA Breast Cancer Coalition (PBCC); Oct 15, 2025; Harrisburg, PA

Radiological Society of North America (RSNA); Nov 30-Dec 4, 2025; Chicago, IL

San Antonio Breast Cancer Symposium (SABCS); Dec 9-12, 2025; San Antonio, TX

Society for Neuro-Oncology (SNO); Nov 19-23, 2025; Honolulu, HI

Society for Immunotherapy of Cancer (SITC); Nov 5-9, 2025; National Harbor, MD

Society of Urologic Oncology (SUO); Dec 2-5, 2025; Dallas, TX

UPCOMING ABSTRACT SUBMISSION DEADLINES

American Association for Cancer Research (AACR); Apr 17-22, 2026; San Diego, CA; Due to publications committee Nov 4, 2025; Submission deadline Nov 18, 2025; LBA and Clinical Trials Jan 6, 2026

American Radium Society (ARS) Annual Meeting; Apr 30-May 3, 2026; Newport Beach, CA; Due to publications committee Oct 17, 2025; Submission deadline Nov 1, 2025, 11:59 pm ET

American Society of Breast Surgeons (ASBrS); Apr 29-May 3, 2026; Seattle, WA; Due to publications committee Oct 24, 2025; Submission deadline Nov 6, 2025, 12:00 am PT; LBA Jan 9, 2026, 12:00 am PT

American Society of Clinical Oncology (ASCO); May 29-Jun 2, 2026; Chicago, IL; Due to publications committee Jan 13, 2026; Submission deadline Jan 27, 2026, 11:59 pm ET; LBA Mar 9, 2026, 12:00 pm ET (placeholder required)

American Society of Clinical Oncology (ASCO) GI; Jan 8-10, 2026; San Francisco, CA; LBA Oct 9, 2025, 12:00 pm ET (placeholder required)

American Society of Clinical Oncology (ASCO) GU; Feb 26-28, 2026; San Francisco, CA; Due to publications committee Oct 7, 2025; Submission deadline Oct 21, 2025, 11:59 pm ET LBA Nov 20, 2025, 12:00 pm ET (placeholder required)

American Society of Colon and Rectal Surgeons (ASCRS); May 9-12, 2026; Tampa, FL; Submission deadline Oct 14, 2025, 11:59 pm ET; LBA and Clinical Trials Jan 28, 2026

European Society of Gynaecological Oncology (ESGO); Feb 26-Mar 1, 2026; Copenhagen, Denmark; Due to publications committee Oct 17, 2025; Submission deadline Oct 31, 2025, 23:59 CET; LBA Jan 15, 2026

ESMO (European Society for Medical Oncology) Breast; May 6-8, 2026; Berlin, Germany; Due to publications committee Jan 13, 2026; Submission deadline Jan 27, 2026, 21:00 CST; LBA Mar 31, 2026, 21:00 CST (placeholder required)

European Society for Radiotherapy and Oncology (ESTRO); May 15-19, 2026; Stockholm, Sweden; Due to publications committee Oct 29, 2025; Submission deadline Nov 12, 2025; LBA Apr 8, 2026

Miami Breast Cancer Conference; Mar 5-8, 2026; Miami, FL; Due to publications committee Dec 22, 2025; Submission deadline Jan 5, 2026

Society of Surgical Oncology (SSO) – Annual Meeting; Mar 5-7; Phoenix, AZ; Submission deadline Oct 13, 2025; LBA Dec 1, 2025, 11:59 pm CT

SSO – Advanced Cancer Therapies; Feb 14-16, 2026; Fort Lauderdale, FL; Due to publications committee Oct 6, 2025; Submission deadline Oct 20, 2025, 11:59 pm CT