September 22, 2025

NRG Oncology Broadcast archives are accessible from our website at any time. Please bookmark this link for your convenience.

Annual Call for Committee Membership Applications

Are you interested in serving on an NRG Oncology committee? NRG Oncology depends on its members to advance its mission. Our members help drive our research, develop protocols, contribute to our science, and so much more. If you are interested in serving on an NRG Oncology research committee, or if you are a member who had previously served on a committee and would like to re-engage please consider applying by following the instructions in the 2025 NRG ONCOLOGY GENERAL AND CORE COMMITTEES APPLICATION FORM and submitting a complete application. 

AMENDMENTS

LUNG

NRG-LU008: Amendment 3, version date August 5, 2025 (posted on CTSU)

CLOSURES & SUSPENSIONS

HEAD & NECK

NRG-HN009: Non-OPC/p16-negative OPC Cohort Temporary Closure, dated September 19, 2025 (posted on CTSU).

FORM UPDATES

LUNG

NRG-LU008: OPEN Eligibility Checklist, Blank Rave Forms Packet (September 16, 2025), Patient History form (April 10, 2025) and PRO-CTCAE Questionnaire (September 27, 2024; English) documents have been updated. The updated versions are posted to CTSU. Please begin using these new forms immediately.

TERMINATIONS

The following NRG Oncology studies are terminated to data collection as of 5 PM ET September 4, 2025:

Breast: NRG-BR002

Developmental Therapeutics/Sarcoma: NRG-DT001

Gastrointestinal: NRG/RTOG 0848; NRG/RTOG 1112

Genitourinary: NRG/RTOG 0815; NRG/RTOG 1115

Gynecologic: NRG/RTOG 0724

Head & Neck: NRG/RTOG 1016; NRG-HN002, NRG-HN004

Lung: NRG-LU001; NRG-LU004

NCORP: NRG-CC003; NRG-CC007CD

Please refer to the official termination memo posted on the NRG Oncology website and on the study-specific protocol pages.

OTHER PROTOCOL NOTICES

ALL DISEASE SITES

NRG-GY022: Reminder: Actively Recruiting MALE Patients only Read More

BIOSPECIMEN BANK

Kit Shipments to Sites in Canada

Important information re: shipments of kits from BB Columbus to Sites in Canada. Please see the memorandum, dated August 18, 2025, posted on CTSU.

Printing Biospecimen Transmittal PDFs from Rave

Please note an effort is underway to clarify how to obtain a Biospecimen Transmittal PDF for submission to the NRG Oncology Biospecimen Bank. Read More

BRAIN

NRG-BN011: Beginning, September 12, 2025, please use the updated NRG-BN011 Gleostine® (lomustine) Clinical Trial Order form (posted on CTSU). An updated memo is also posted on CTSU.

NRG-BN014: The Spanish-translated consent form for Amendment 1 and CIRB approval of the form are available on the CTSU website.

BREAST

NRG-BR009/OFSET: Site-Directed Video Tools

CANCER PREVENTION & CONTROL

NRG-CC005/FORTE: Clinical research professionals can sign up for NRG Oncology Weekly Broadcasts to receive monthly FORTE Fridays updates directly to your inbox (click here).

GASTROINTESTINAL

NRG-GI011: Canadian Informed Consent posted on CTSU.

GENITOURINARY

NRG-GU015: Canadian Informed Consent posted on CTSU.

GYNECOLOGIC

NRG-GY025: Now accruing to the Phase II portion. The Phase II ICD should be used for patients entered from this point forward. Documents are posted on CTSU.

NRG-GY026: Reminder! Now accruing patients of all stages and all histologic subtypes of endometrial cancer.

NRG-GY031: Please note, there is an error in the section 4.2 table and the Biospecimen Collection and Submission Manual. The Part I PK collection is to be done on Cycle 1, Day 1, and Cycle 1, Day 8. This will be updated with the next amendment.

HEAD & NECK

NRG-HN008 - Reminder: please update treatment and AE data weekly. This is a Phase I trial and timely data submission is very important.

NRG-HN014: The September 2025 Study Newsletter was released on September, 17, 2025 and is now available on the CTSU Website.

VTOC TRAINING

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on NRG-BN014, NRG-BR009, NRG-CC005, NRG-CC011, NRG-CC013, NRG-CC014, NRG-CC015, NRG-GU015, and NRG-HN014. Space is limited so register now and reserve your seat. The next webinar training is scheduled for October 8, 2025.

Safety updates have been issued for the following studies:

1. Cancer Prevention and Control - NRG-CC008 Webinar

The study chairs and team will be hosting a webinar on Friday, October 3, 2025, 12:00 – 1:00pmET, to discuss baseline PRO completion, subject retention/long-term follow-up, address protocol amendment questions and STIC lesions. We’d also like to hear from participating sites about their experiences with this trial. Please register in advance for this meeting here. After registering, you will receive a confirmation email containing information about joining the meeting.

2. NRG-BR009/OFSET Study Webinars

The BR009 Protocol Leadership is planning webinars for the NRG-BR009 trial on September 30, October 6, 7, and 9. There will be an overview of the protocol and frequently asked questions will be discussed. There will also be time for questions and answers. These webinars are intended for BR009 research staff at the sites, for sites that currently have NRG-BR009 open, as well as those interested in opening BR009 at their site in the future. To register to attend one of the sessions please click here. If you have questions about the webinars, please contact the Clinical Coordinating Department at ccdPGH@NRGOncology.org

3. NRG Presentation Slide Templates

NRG Oncology recently revised the NRG presentation slide template. You can find the template here on the NRG website.

4. NRG Oncology Podcast NEW EPISODE

Our NRG Oncology Podcast co-hosts recently sat with Dr. Wafik El-Deiry regarding precision oncology, clinical research, and industry collaborations. Learn more about our podcast and stream the latest episodes at www.NRGOncology.org/Podcast. Special ASTRO 2025 episodes are coming soon, so be sure to follow us where you find your podcasts!

5. NCORP Pilot Grant – Call for Letter of Intent (LOI)

NRG NCORP is soliciting LOIs in preparation for the next NCORP pilot grant RFA.

• Anyone interested in applying must submit a Letter of Intent (LOI) by October 24, 2025. Click here to download the form
• The request for funding application (RFA) for NCORP pilot projects will be released in Spring 2026; however, interested applicants must submit a LOI.
• NCORP committee chairs will review LOIs and select those best aligned with committee goals, NCORP priorities and feasible.
• Selected investigators will be notified and invited to attend a workshop the NRG Winter Meeting in San Francisco, CA; January 22-24, 2026

For more information slides are available here.

6. NRG Oncology Current Committee Member Openings

• Annual Call for Committee Member Applications
  Applications DUE October 6, 2025 - Read more & How to Apply 
  
• Members, Protocol Support Committee (PSC) General Committee
  Applications DUE October 16, 2025 - Read more & How to Apply

7. NRG Oncology Current Committee Leadership Openings

• Medical Oncologist Vice Chair, Lung Cancer Committee
  Applications DUE September 24, 2025 - Read more & How to Apply
  
• Chair, NRG Oncology Medical Oncology Committee
  Applications DUE September 29, 2025 - Read more & How to Apply
  
• Translational Science Vice Chair, Developmental Therapeutics Committee
  Applications DUE September 29, 2025 - Read more & How to Apply
  
• Translational Science Vice Chair, Lung Cancer Committee
  Applications DUE September 29, 2025 - Read more & How to Apply
  
• Chair, Translational Science Committee
  Applications DUE September 29, 2025 - Read more & How to Apply
  
• Vice Chairs (2) PSC Subcommittees 
  Applications DUE October 16, 2025 - Read more & How to Apply 
  
• Vice Chair, Surgical Oncologist Brain Tumor Committee
  Applications DUE October 20, 2025 - Read more & How to Apply
  
• Vice Chair, Translational Science Brain Tumor Committee
  Applications DUE October 20, 2025 - Read more & How to Apply
  
• Vice Chair, Neuro-Oncologist/Medical Oncologist Brain Tumor Committee
  Applications DUE October 20, 2025 - Read more & How to Apply
  
• Vice Chair, Radiation Oncologist Breast Cancer Committee
  Applications DUE October 20, 2025 - Read more & How to Apply
  
• Vice Chair, Translational Science Committee
  Applications DUE October 20, 2025 - Read more & How to Apply

10. NRG Member Information Form

We are excited to introduce the NRG Member Information Data Collection Initiative that will allow us to create a comprehensive member database, enabling us to better understand and serve our members. Your information will be kept secure and confidential, ensuring that your privacy is always protected. All members are encouraged to complete the form or indicate that they wish to opt out of this data collection initiative. 

Scan the QR code below or click this link to access the form. 

Questions? Read more here

NRG Oncology is pleased to report the following abstracts accepted for presentation at the 2025 San Antonio Breast Cancer Symposium.

ACCEPTED ABSTRACTS

Mamounas EP, Bandos H, Sweeney K, Tran K, Chen E, Rastogi P, Valero V, Freeman TJ, Geyer CE Jr., Fehrenbacher L, Chia SK, Brufsky AM, Walshe JM, Soori GS, Dakhil SR, Paik S, Swain SM, Wolmark N, Symmans WF. Evaluation of the Sensitivity to Endocrine Therapy (SET ER/PR) Assay to Predict Benefit from Extended Endocrine Therapy in the NSABP B-42 trial. SABCS (San Antonio Breast Cancer Symposium). Dec 9-12, 2025. Oral Presentation.

Swain SM, Tang G, Puhalla SL, Ganz PA, Henry NL, Cecchini RS, Reid S, Rastogi P, Geyer CE Jr., White J, Clark AS, Haddad TC, Vidal GA, Wolmark N, Mamounas EP. NRG-BR009: Phase III Trial Evaluating Addition of Adjuvant Chemotherapy to Ovarian Function Suppression + Endocrine Therapy in Premenopausal Women with pN0-1, HR+/HER2- Breast Cancer and Oncotype Recurrence Score ≤25 (OFSET). SABCS (San Antonio Breast Cancer Symposium). Dec 9-12, 2025. Poster Presentation, 2025 Dec 12; Abstract # 150.

White J, Cecchini RS, Harris EE, Mamounas EP, Stover DG, Ganz PA, Jagsi R, Anderson SJ, Bergom C, Theberge V, El-Tamer M, Zellars RC, Shumway DA, Chen G, Julian TB, Wolmark N. A phase III trial evaluating De-escalation of Breast Radiation (DEBRA) following breast-conserving surgery of stage 1, HR+, HER2-, RS ≤18 breast cancer: NRG-BR007. SABCS (San Antonio Breast Cancer Symposium). Dec 9-12, 2025. Poster Presentation, 2025 Dec 12; Abstract # 1704.

Please note the following upcoming meetings and abstract submission deadlines

UPCOMING MEETINGS

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; Oct 22-26, 2025; Boston, MA

American Society for Radiation Oncology (ASTRO); Sep 28-Oct 1, 2025; San Francisco, CA

European Society for Medical Oncology (ESMO); Oct 17-21, 2025; Berlin, Germany

International Society for Quality-of-Life Research (ISOQOL); Oct 22-25, 2025; Milwaukee, WI

PA Breast Cancer Coalition (PBCC); Oct 15, 2025; Harrisburg, PA

Radiological Society of North America (RSNA); Nov 30-Dec 4, 2025; Chicago, IL

Society for Neuro-Oncology (SNO); Nov 19-23, 2025; Honolulu, HI

Society for Immunotherapy of Cancer (SITC); Nov 5-9, 2025; National Harbor, MD

UPCOMING ABSTRACT SUBMISSION DEADLINES

American Association for Cancer Research (AACR); Apr 17-22, 2026; San Diego, CA; Due to publications committee Nov 4, 2025; Submission deadline Nov 18, 2025; LBA and Clinical Trials Jan 6, 2026

American Society of Clinical Oncology (ASCO); May 29-Jun 2, 2026; Chicago, IL; Due to publications committee Jan 13, 2026; Submission deadline Jan 27, 2026, 11:59 pm ET; LBA Mar 9, 2026, 12:00 pm ET (placeholder required)

American Society of Clinical Oncology (ASCO) GI; Jan 8-10, 2026; San Francisco, CA; Due to publications committee Oct 7, 2025; Submission deadline Oct 21, 2025, 11:59 pm ET LBA Oct 9, 2025, 12:00 pm ET (placeholder required)

American Society of Clinical Oncology (ASCO) GU; Feb 26-28, 2026; San Francisco, CA; LBA Nov 20, 2025, 12:00 pm ET (placeholder required)

American Society of Colon and Rectal Surgeons (ASCRS); May 9-12, 2026; Tampa, FL; Due to publications committee Sep 30, 2025; Submission deadline Oct 14, 2025, 11:59 pm ET; LBA and Clinical Trials Jan 28, 2026

European Society of Gynaecological Oncology (ESGO); Feb 26-Mar 1, 2026; Copenhagen, Denmark; Due to publications committee Oct 17, 2025; Submission deadline Oct 31, 2025, 23:59 CET; LBA Jan 15, 2026

European Society for Radiotherapy and Oncology (ESTRO); May 15-19, 2026; Stockholm, Sweden; Due to publications committee Oct 29, 2025; Submission deadline Nov 12, 2025; LBA Apr 8, 2026

International Gynecologic Cancer Society (IGCS); Nov 5-7, 2025; Cape Town, South Africa; LBA Sep 29, 2025 (placeholder required)

San Antonio Breast Cancer Symposium (SABCS); Dec 9-12, 2025; San Antonio, TX; LBA Sep 30, 2025, 11:59 pm CT

SSO - Advanced Cancer Therapies; Feb 14-16, 2026; Fort Lauderdale, FL; Due to publications committee Oct 6, 2025; Submission deadline Oct 20, 2025, 11:59 pm CT

Society of Urologic Oncology (SUO); Dec 2-5, 2025; Dallas, TX; LBA Oct 1, 2025