LDA NEWS & UPDATES 

January 31, 2023

Neuropsychiatric Symptoms and Tick-Borne Diseases

A Comprehensive Look

Shannon L. Delaney, Lilly A. Murray, and Brian A. Fallon published the chapter “Neuropsychiatric Symptoms and Tick-Borne Diseases” in the book series Current Topics in Behavioral Neurosciences on December 14, 2022. The chapter’s focal point is on the neuropsychiatric facets of Lyme disease, which are less recognized by doctors and commonly overlooked. The aim of the researchers is to offer a more extensive education about the prospective intricacy, severity, and wide-ranging symptom manifestations of tick-borne diseases. Read more.

Read the chapter.

Clinical Trials Network Announces Third Round

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Pilot Study Proposals Welcome

Columbia University Irving Medical Center’s Clinical Trials Network (CTN) for Lyme and Other Tick-Borne Diseases, established with a grant from the Steven & Alexandra Cohen Foundation to Columbia University, has announced the third round of Pilot Study Proposal submissions. Clinicians, researchers, and investigators from educational institutions are welcome to submit proposals. Read more.

PTLDS and Language Fluency Deficits

An Independent Neurocognitive Deficit?

Marianne Gorlyn, et al., published “Language Fluency Deficits in Post-treatment Lyme Disease Syndrome” in Archives of Clinical Neuropsychology on December 12, 2022. The goal of the study was to ascertain whether language fluency deficits could be explained by poor performance in these other neurocognitive areas as well as to determine whether they are secondary to poor memory and slowing rather than an independent deficit. Read more.

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Billing Patient Portal Messages as E-Visits

Does it Affect Patient Messaging Volume?

Jay Holmgren, Ph.D., MHI, et al, published “Association Between Billing Patient Portal Messages as e-Visits and Patient Messaging Volume” online, in JAMA, on January 6, 2023. The purpose of the study was to analyze the utilization of clinician-initiated e-visit billing which expanded following the onset of the COVID-19 pandemic. The researchers sought to gain a better understanding of the level at which clinicians adopted the revised billing protocols as they related to patient messaging behavior. Read more.

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Prescribed Forest Burns Can Reduce Ticks Study Shows

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Added Benefit of Reducing Ticks

An article written by Ad Crable on bayjournal.com titled “Study: Controlled burns reduce ticks, Lyme disease” was published on January 13, 2023. The article covers a study published in Ecological Applications by Michael Gallagher, et al., in which researchers from Penn State, the U.S. Forest Service and New Jersey Department of Environmental Protection demonstrated that “more use of prescribed burns on public and private forests could help reduce both the numbers of ticks and incidence of the disease.” Go back to read more in burn article.

Advances in Deciphering Ixodes Scapularis Genome

Evolving Tick Science

Sandip De, et al, published “A high-quality Ixodes scapularis genome advances tick science” in Nature Genetics on January 19, 2023. The researchers sought to decipher a high-quality genome to gain better knowledge of tick biology and aid in the development of anti-tick methods. Read more.

Read the study.

Alessandra Luchini Receives Outstanding Faculty Award

Alessandra Luchini, Ph.D.

2016 LDA-CU Conf. Speaker

George Mason University announced on January 16, 2023, via gmu.edu that faculty member, Alessandra Luchini, Ph.D., is one of 12 Virginia educators formally recognized by the State Council of Higher

Education for Virginia (SCHEV) with a 2023 Outstanding Faculty Award. Dr. Luchini is a professor at Mason’s Center for Applied Proteomics and Molecular Medicine (CAPMM) within the College of Science. Read more.


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Powassan Virus in D. Variabilis Ticks in New York

Emerging Virus

Charles Hart, et al., published “Powassan Virus Lineage I in Field-Collected Dermacentor variabilis Ticks, New York, USA" in Emerging Infectious Diseases on January 13, 2023.

Powassan virus (POWV) is a tickborne flavivirus that can cause lethal or debilitating neurologic illness. The virus was initially found in the woodchuck tick, Ixodes cookei, and later in the I. scapularis tick. Read more.


Dermacentor Variabilis

Credit: James Occi, Ph.D.


Read the study.

Model for Neuro-Lyme: 3D Blood-Brain Barrier-Organoids

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Spirochetes Cross the Blood-Brain Barrier

Yvonne Adams, et al., published “3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism" in iScience on December 19, 2022. Lyme neuroborreliosis caused by spirochetes within the Borrelia burgdorferi sensu lato (s.l.) species complex, is one of the most widespread bacterial central nervous system infections in US and Europe. Read more.

Borrelia lonestari: Pathogen of Relapsing Fever in AL

Report of Immunocompromised Patient in Alabama

Laia Vazquez Guillamet, et al., published the research letter “Relapsing Fever Caused by Borrelia lonestari after Tick Bite in Alabama, USA” in the February 2023 issue of Emerging Infectious Diseases. In this letter, authors report the identification of B. lonestari causing relapsing fever in an immunocompromised patient in Alabama. Read more.

Read the letter.

Novel Inducers of Inflammatory Mediators in Neuro-Lyme

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Evidence Sheds Light on Improved Treatment

Geetha Parthasarathy, et al., published “The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions” in Journal of Inflammation on January 17, 2023. The study investigated the role of the FGF/FGFR system in primary rhesus microglia which is shown to be the most significant neuronal support cell for neuroinflammation in the central nervous system. Read more.

Herx Reaction and Babesia Complicate Lyme Case

Need for Provider Awareness & Education

Maria Karim, et al., published “A case of Lyme disease complicated by the Jarisch-Herxheimer reaction and coinfection with Babesia” in JAAD Case Reports on November 30, 2022. The case report describes a Lyme disease patient case in an endemic area that was complicated by a Jarisch-Herxheimer reaction (JHR) and Babesia coinfection. Read more.

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Transfusion-Transmitted Babesiosis

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Case Involves Sickle Cell Disease Patient

Victoria Costa, et al., published “Transfusion-transmitted babesiosis in a patient with sickle cell disease undergoing chronic red cell exchange” in Transfusion on January 13, 2023. The report describes a 30-year-old man with sickle cell disease who presented with fever, neck pain, and photophobia roughly two months after receiving red cell exchange, a regimen he had been receiving since childhood. Read more.

Update on Tickborne Bourbon Virus in US & NY

Read the synopsis.

Ongoing Study & Surveillance is Needed

Molly K. Roe, et al., published the synopsis “Comprehensive Review of Emergence and Virology of Tickborne Bourbon Virus in the United States” in the CDC’s January 2023 issue of Emerging Infectious Diseases. The purpose of the study was to better understand the biology of Bourbon virus (BRBV). Read more.

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  Amazon Announcement!

 

AmazonSmile Closing February 20th

Amazon has announced that on February 20, 2023, it will be shutting down AmazonSmile which donates a portion of your purchases to a charity.

 

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