There was increased risk for occurrence of brain aneurysms due to the presence of polycystic kidney disease. However, overall risk of aneurysm rupture was assumed to be relatively low. Patient was not a smoker, had no arterial hypertension, a negative family history for brain aneurysms, and agreed to be included in an individualized unruptured brain aneurysm surveillance program. In addition, patient participated in an experimental drug program with daily oral dose of minocycline which was well tolerated.
Twelve years following the diagnosis of two brain aneurysms, the patient (now 65 years-old) remains asymptomatic with stable anatomy of both middle cerebral artery aneurysms (last brain MRA from 2019 shown in Figures 1 and 2; 3D-rendered images from 2010 vs. 2017 in Figure 3). Predicted 5-y risk of rupture is 0.4% (95% CI 0.1-1.5%) per PHASES risk score.