Non-invasive Fluorescence Imaging of Breast Cancer Metastasis to the Brain Using the

UVP BioSpectrum Advanced

Figure 1: Non-invasive RFP fluorescence images of breast cancer growing in the brain. A) Front side. B) Right side. C) Left side.

Cancer is the second leading cause of death worldwide. Metastasis within cancer patients is very difficult to treat and track. Breast cancer metastasis has been known to be unresponsive to radiation and chemotherapy. In the present study, researchers used the human triplenegative breast cancer cell line MDA-MB-231 expressing high levels of red fluorescent protein (RFP) and the high-power imaging capability of the Analytik Jena UVP BioSpectrum Advanced system to develop a precise model of brain metastatic of breast cancer. The very-narrowband-width laser excitation of the UVP BioSpectrum Advanced gave an ultra- bright signal with no skin autofluorescence background, essential for non-invasive imaging. 

The UVP BioSpectrum Advanced represents a comprehensive BioImaging solution, integrating in vivo imaging functionalities for sample documentation and analysis across various domains such as in vivo animal imaging, plant imaging, chemiluminescence, NIR, and fluorescence. This versatile system caters to diverse laboratory settings including research institutions, medical facilities, academic research institutions, pharmaceutical companies, and more. Equipped with a selection of deeply-cooled CCD camera sensors capable of capturing fluorescence, chemiluminescence, and bioluminescence, the system also boasts extended NIR, red, green, and blue laser bars, along with white epi (overhead) illumination, motorized platform lift, filter wheel, and automated lens. Furthermore, users have the option to augment the system with accessories like a sample warming plate, UV light transilluminator, or blue light transilluminator to meet specific application requirements.

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