March 20, 2024 | Office of the President & Chief Research Officer

Stanley Manne Children's Research Institute President's Message

New Insights Open Up Possibilities in Autism Research

Dear Friends and Colleagues,

As we expand our role as a national leader in pediatric research, we recently welcomed a new leader who will develop Manne Research Institute’s area of focus in autism spectrum disorder (ASD). Joshua Ewen, MD, a child neurologist and a neurodevelopment pediatrician, is the new Division Head of Developmental and Behavioral Pediatrics. His research is generating insights into the cognitive changes that cause disability in individuals with ASD to identify improved interventions.

Imitation is a fundamental skill needed for complex learning in language, social interactions, and cognitive responses to the world around us. Children with ASD frequently have deficits in imitation, and as a result, they may have atypical body movements, use of objects around them, facial expressions, social engagement, and vocal expressions. Much of Josh’s research has concentrated on the relation of imitation and motor control to cognitive differences in autism that impair quality of life. In recent years, though, he has developed and implemented a novel approach utilizing advanced statistical modeling coupled with large psychological datasets around autism to evaluate previously untested theories of autism. What’s exciting for him is the potential to apply this method to other untested theories behind the cause of the autism phenotype. These results should provide researchers with statistical evidence that identifies areas with the greatest chance of improving lives.


Josh will also leverage his research expertise and extensive clinical care experience as the co-director for the neurodevelopment core of the Institute of Innovations in Developmental Sciences (DevSci) at Northwestern University. Our partnership with DevSci engages researchers to build strong cross-disciplinary connections, streamlining the translation of research results into interventions. Within the neurodevelopment core, Josh will support the efforts of researchers across disciplines at the research institute and Northwestern University to access and implement the latest tools to look at neurological functions and development. Importantly, his leadership roles in clinical and research realms will allow him to facilitate collaborations, bringing together researchers and clinicians to share insights and build translational efforts.

Autism is one of the most prevalent lifelong health conditions for children, and yet, huge gaps exist in understanding the disorder and treating it with high-quality, evidence-based interventions. That is why investment in autism research and our leadership involvement in DevSci is extremely meaningful for Josh: “We don’t talk about curing autism, but we do talk about how to help people with autism achieve self-actualization and reduced rates of depression or anxiety.” Josh hopes that by rethinking areas of research focus and bridging the gap between researchers and clinicians, we can improve our understanding of ASD and develop interventions to ensure that children with autism enjoy the improved quality of life that they deserve.


With kindness and respect,

Pat

Patrick C. Seed, MD, PhD, FAAP, FIDSA
President & Chief Research Officer
Stanley Manne Children’s Research Institute
Children's Research Fund Chair in Basic Science
Director, Host - Microbial Interactions, Inflammation, and Immunity (HMI3) Program
Professor of Pediatrics, Microbiology & Immunology
Northwestern University Feinberg School of Medicine
Ann & Robert H. Lurie Children’s Hospital of Chicago
X Share This Email
LinkedIn Share This Email
Lurie Children's logo
X  Linkedin