Contingency management strategies can be used to treat smoking, but they require objective methods to verify quitting status.
To test whether methylation can be used to verify cessation, we determined monthly cg05575921 levels in 67 self-reported smokers undergoing biochemically monitored contingency management-based smoking cessation therapy as part of a lung imaging protocol.
Findings conclude that DNA methylation may be a useful tool to guide and incentivize contingency management-based approaches for smoking cessation.