Developing Concerns: Does Leucovorin Cure Autism? | | |
On September 22, 2025 HHS Secretary Kennedy announced that “Today, we are taking bold action…to confront the nation’s autism spectrum disorder (ASD) epidemic" opening the door to the first FDA-recognized treatment pathway, informing doctors and families about potential risks, and investing in groundbreaking research. We will follow the science, restore trust, and deliver hope to millions of American families The FDA is publishing label update for leucovorin for cerebral folate deficiency, which has been associated with autism. This action establishes the first FDA-recognized therapeutic for children with cerebral folate deficiency and autistic symptoms.”
What is cerebral folate deficiency (CFD) and how does it relate to autism spectrum disorders (ASD)?
The concept behind CFD is that there is a deficiency of folate (an essential B vitamin) in the brain, even when the folate levels in the rest of the body are normal. This is thought to be due to inherited mutations or autoantibodies. The rare genetic form is thought to affect 1 in 1,000,000. The prevalence of autoantibodies is extremely controversial, since the current ability to measure them is quite inconsistent. CFD presents in early childhood with severe neurological symptoms (seizures, movement disorders) and developmental delay. Some individuals with CFD have been diagnosed with ASD. CFD is the result of the loss of function of the cerebral folate receptor alpha protein, causing low levels of folate in the CSF and brain.
What is leucovorin and does it improve ASD?...Continue reading...
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Renee Wachtel, MD, FAAP
Chair, Committee on Developmental & Behavioral Pediatrics and School Health Committee, Area Director, Alameda County, AAP-CA1
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Two-Part Series: Pediatric Nutrition Webinar
The California Society of Pediatric Dentistry (CSPD) is pleased to present a two-part continuing education webinar series focused on pediatric nutrition and its impact on oral and overall health.
Part 1: More Chocolate: The Fun Biochemistry of Cavity Prevention
Wednesday, Nov 4 | 6:00–7:30 PM | Dr. Roger Lucas
Learn how pediatric nutrition impacts dental development, cavity prevention, and long-term oral health.
Part 2: Beyond the Scale: Addressing Pediatric Obesity in Every Practice
Wednesday, Nov 18 | 6:00–7:30 PM | Dr. Sushma Chamarthi
Gain practical tools to recognize and manage pediatric obesity using the 2023 AAP Guidelines, nutrition counseling, and insights on ultra-processed foods.
Deadline to register is November 3rd!
Tentatively offering 3 CME credits!
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San Francisco - Life After Residency In-Person Mixer
Join us to meet fellow pediatricians and potential mentors as you prepare to begin your journey beyond residency! AAP-CA1 Board Members and Area Directors are excited to host regional informal and in-person mixer sessions designed to help residents connect with pediatrician leaders across Northern California.
Please RSVP below to confirm your attendance and share any dietary restrictions or food allergies so we can plan accordingly. If you have any questions, please contact Sana at projectcoordinator@aapca1.org.
Date: Wednesday, November 5
Time: 6:00-7:30 pm
Location: Ballast Point (705 16th St, San Francisco, CA 94158)
📍RSVP for any of our other in-person mixer events for:
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Palo Alto/San Mateo - Pinstripes (36 Hillsdale Mall, San Mateo, CA 94403)
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Fresno - (Casa de Tamales 805 E Olive Ave, Fresno, CA 93728)
- Sacramento - location pending (you may still RSVP)
- Oakland - location pending (you may still RSVP)
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Committee Meeting: Mental Health Committee
We would like to invite you to join our next Mental Health Committee meeting virtually on Wednesday, November 12 from 6:30-7:30 P.M! AAPCA1’s Mental Health Committee invites you to a virtual meeting focused on sharing mental health resources and strategies for both patients and providers. We'll discuss ways to better support individuals facing mental health challenges, highlight available community resources, and explore opportunities to strengthen care in your practice.
Date: Wednesday, Nov. 12
Time: 06:30 p.m. – 07:30 p.m. PDT
Location: via Zoom
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Chapter Chat: AAP CATCH Grants Info Session
Join us for a FREE interactive webinar and Q&A to learn about the CATCH (Community Access to Child Health) Grant Program on Monday, November 17 from 6PM to 7PM! The session will highlight how CATCH Planning, Implementation, and Resident Grants help pediatricians and trainees bring innovative child health ideas to life, especially projects that build community partnerships, address health disparities, and improve access to care.
Date: Monday, Nov. 17
Time: 06:00 p.m. – 07:00 p.m. PDT
Location: via Zoom
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Amplify Your Advocacy Op-Ed Writing for Pediatricians
AAP-CA1 invites you to join the joint committee meeting with the Committee on Developmental & Behavioral Pediatrics and the School Health Committee, held virtually on Tuesday, October 28, from 7:00 p.m. to 8:30 p.m. Don’t miss this important discussion on developmental, behavioral, and school health topics!
Date: Wednesday, December 10
Time: 06:30 p.m. – 08:00 p.m. PDT
Location: via Zoom
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CME Lecture - Artificial Intelligence in Pediatric Mental Health
Join us for this collaborative continuing education event, presented by the AAP-CA3, Smart Care BHCS, SD County HHSA, and SDACAP. Dr. Niranjan Karnik, MD, Ph.D will present on AI in Child & Adolescent Psychiatry. He is the Director, Institute for Juvenile Research, Department of Psychiatry, and Interim Director, AI.Health4All Center for Health Equity using ML/AI, at the University of Illinois Chicago, College of Medicine.
Date: Monday, Nov. 3
Time: 6:30 p.m. - 8:00 p.m. PT
Location: via Zoom
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AAP-CA's 46th Annual Las Vegas Seminars
We personally invite you to attend this year’s Annual Las Vegas Seminars at the beautiful Caesars Palace Las Vegas! This meeting is the largest regional Pediatric Conference in the country, thanks to the continued support and participation of individuals like you.
Date: November 14-16
Location: Caesars Palace, Las Vegas
Up to 16 AMA PRA Category 1 Credit(s)™ available
Chapter Members receive a $75 discount!
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ACES Health Champions Gathering
Immigrant children and families face growing levels of stress often missed by traditional systems. This gathering explores how collaboration across mental health, education, media/TV, and community organizing can create exponential impact.
Date: Monday, November 17, 2025
Location: via Zoom
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Cal-MAP Presents Primary Care Project ECHO Series & School-Based Project ECHO Series!
The California Child and Adolescent Mental Health Access Portal (Cal-MAP) offers live interprofessional tele-mentoring and consultation with school-based teachers, administrators & staff and school-based health center staff focuses on on topics including bullying, disruptive behaviors, anxiety, autism and suicidality and mental and behavioral health presentations common in school-based settings.
Upcoming Primary Care Project ECHO Series:
All events in this series are from 12:00 pm – 01:00 pm PDT
Upcoming School-Based Project ECHO Series:
All events in this series are from 09:00 am – 10:00 am PDT
Monthly Cal-MAP Webinar Series: Oct. 3, Nov. 7, Dec. 5 – Register Here!
CME, APA, ACE, and ASWB credits available
Some sessions may also qualify for MOC Part 2 and AAFP CME credits.
📌 Visit Cal-MAP to access program details and session recordings.
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KP Webinar Series on Firearm Violence Research
The Kaiser Permanente Center is launching a bimonthly webinar series designed to build the capacity, confidence, and visibility of those navigating the complexities of firearm violence research and prevention.
Each webinar will offer an opportunity to learn from a community of leading researchers and practitioners, receive expert guidance, and engage with peers in the field.
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December 2025 | Navigating IRBs in Firearm Violence Research: What You Need to Know
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February 2026 | Built on Trust: Community Partnerships for Firearm Violence Prevention Research
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April 2026 | It’s Not Just What You Do – It’s How You Do It: Implementation Science for Firearm Violence Prevention
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June 2026 | Not Just a Report: Disseminating Firearm Violence Research for Impact
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Pediatric Careers in California!
Explore our job board for exciting career opportunities or share one of your own. Visit aapca1.org/jobs/.
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Chapter Members: Enjoy a discounted rate of $50 for a 90-day job posting and promotion.
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Non-Members/Corporate Entities: Post for 30 days at $100.
Take the next step in your pediatric career today!
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Pediatric Jobs Available!
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SIDS Awareness Toolkit
Most children with ADHD have their first encounter for care within their primary clinician’s practice, their “medical home.”
These tools help you prepare for that encounter and beyond: readying your staff, screening, diagnosis, treatment, ongoing follow-up, and negotiating insurance payments for every step your patients need...
Recommended by AAP
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UC Davis Health: Kids Considered Podcast
Kids Considered podcast features two pediatricians who discuss child health topics of interest to parents in plain, non-medical language. Hosted by Dr. Dean Blumberg and Dr. Lena van der List.
Recommended by AAP-CA1 Area Director Lena van der List
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Cal-MAP: Mental Health Support Resources
Cal-MAP’s team of mental health specialists supports primary care providers (PCPs) treating youth with mental health needs through education, consultation, and resource navigation.
Register for the Cal-MAP consultation program here: https://cal-map.org
Contact Us:
Phone:
800-253-2103
Email: info@cal-map.org
| | | California Pediatrics Podcast | | |
Reach Out & Read: Reading Recs
Books:
A Box Can Be Many Things
What Will We Build Today?
The Big Umbrella
Recommended by Reach out and Read
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Your membership makes a difference for children in California, thank you!
The AAPCA1's ability to advocate on behalf of children is only as strong as the support we receive from our members. Encourage your colleagues to join today by visiting the AAPCA1 website.
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Our mission is to promote the optimal health and development of children and
adolescents of Northern California in partnership with their families and communities, and to support the pediatricians who care for them.
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Executive Committee:
President: Neel Patel • Vice President: Saul Diaz Martinez
• Secretary: Kerrilyn Rice • Treasurer: Amita Saxena • Past President: Nicole Webb
Area Directors:
North Valley: Aishwarya Taneja • Sacramento Valley: Lena van der List • Central Valley: Deborah Shassetz • South Valley: Sireesha Palkamsetti • San Francisco: Ryan Alanzalon • Santa Clara: Swetang Shahm • San Mateo: Jonathon Everett • North Coastal: VACANT • Monterey Bay: VACANT • Alameda County: Renee Wachtel • Contra Costa/Solano: Jennifer Anne Miller
Pediatric Insider News Editors:
Christy Capestany • Nicole Anderson
Staff:
Executive Director: Yolanda Ruiz • Project Coordinator: Sana Sayyid •
Marketing Assistant: Arathzy Portillo
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