Issue 27 | April 2019

I hope you will be able to attend the upcoming Pediatric Academic Societies (PAS) Meeting! The meeting will include a PTN symposium, providing our investigators with the opportunity to share their experiences and lessons learned from more than a decade of pediatric research. More details, as well as a complete agenda, are included below. Since our last POST, exciting PTN research was released that examines the systemic exposure of timolol as treatment for hemagiomas, or strawberry birthmarks. Check out the highlight below to learn more. As always, we are thankful for everyone involved in the PTN. Your commitment to our mission of informing formulation, dosing, efficacy, and safety of drugs, as well as medical devices, used in pediatric patients makes a huge impact. Danny Benjamin, MD, PhD, MPH

PTN at the Pediatric Academic Societies (PAS) Meeting

On April 28, PTN will host a symposium titled “Clinical Research in the Pediatric Population: A Network Perspective,” at the annual Pediatric Academic Societies (PAS) meeting in Baltimore, MD. During the symposium, p articipants will learn about the PTN, its contributions to child health, and its unique perspectives as a network of more than 100 pediatric clinical research sites across the globe.   The symposium will begin with a brief overview of the PTN and the Best Pharmaceuticals for Children Act (BPCA), which aims to encourage the pharmaceutical industry to perform pediatric studies to improve labeling for medical products used in children. Dr. Perdita Taylor-Zapata, Pediatric Medical Officer at the NICHD, and Dr. Kanecia Zimmerman, Assistant Professor of Pediatrics at the Duke University School of Medicine, will provide opening remarks.

PTN Symposium Agenda

Register here

Arrival and Refreshments (7:30 – 7:50 p.m.) Welcome and Brief History of BPCA and PTN (7:50 – 8:00 p.m.)

Perdita Taylor-Zapata, MD Pediatric Medical Officer Obstetric and Pediatric Pharmacology and Therapeutics Branch NICHD, NIH

Kanecia Zimmerman, MD, MPH Assistant Professor of Pediatrics Division of Pediatric Critical Care Medicine Duke Children’s Hospital Duke Clinical Research Institute

Real World Applications / PTN in Clinical Practice (8:00 – 8:40 p.m.)

Matthew M. Laughon, MD, MPH Professor of Pediatrics The University of North Carolina at Chapel Hill

Kelly Wade, MD PhD MSCE Neonatology, Children's Hospital of Philadelphia (CHOP) Newborn Care at Pennsylvania Hospital Associate Professor Clinical Pediatrics, Perelman School of Medicine

Ten-minute survey – Lay Summaries of Study Results (8:40 – 8:50 p.m.)

Caregiver / Participant Engagement (8:50 – 9:40 p.m.)

Panel discussion with parents & adolescent participants International Children’s Advisory Network (iCAN)

Partnering Opportunities / Working within & across networks (9:40 – 10:00 p.m.)

Janice E. Sullivan, M.D. Professor and Vice Chair for Research Department of Pediatrics Division Chief, Pediatric Clinical & Translational Research Medical Director, KCPCRU University of Louisville School of Medicine

Future Opportunities & Closing Remarks (10:00 – 10:10 p.m.)

Perdita Taylor-Zapata, MD

Recent PTN News

PTN Evaluates Systemic Exposure of Timolol as Treatment for Infantile Hemangiomas PTN  recently published research  in the  Journal of the American Academy of Dermatology (JAAD)  that explores whether topical timolol used on infants is absorbed through the skin and can be detected in the blood. The newly published research shares findings from a study led by Drs. Beth Ann Drolet and Kristen Holland of the Medical College of Wisconsin in Milwaukee.  Learn more .

Recruiting soon: Pharmacokinetics and Safety Profile of Digoxin in Infants with Single Ventricle Congenital Heart Disease Currently enrolling: Pharmacokinetics and Safety of Anesthetics and Analgesics in Children and Adolescents (ANA) Long-term Antipsychotic Pediatric Safety Trial (LAPS) Pharmacokinetics of Anti-epileptic Drugs in Obese Children (AED) Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care (POPS) Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (CUDDLE) Efficacy, Pharmacokinetics, and Safety of Topical Timolol in Infants with Infantile Hemangioma Safety of Sildenafil in Premature Infants at Risk of Bronchopulmonary Dysplasia

We want your stories! If your involvement in PTN has had an impact on you, your career, or your care for patients, we want to hear from you. Please send an email to   PTN-Program-Manager@dm.duke.edu  to share your story. We may feature it on our website and in an upcoming newsletter!

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