(1) TRK background as a drug target
- TRK biology
- TRK role in cancer
- TRK inhibitors launched and under development
(2) TRK biochemical assay
(3) TRK cell based assay
(4) TRK related CDX models
- KM-12 colorectal cancer CDX model with TPM3-NTRK1 fusion
- TRK related genetically engineered Ba/F3-TRK fusion models, validated with LOXO-101 and Entrectinib both in vitro and in vivo
(5) TRK related PDX models
- CO-04-0284 colorectal cancer PDX model with TPM3-NTRK1 fusion, validated with Entrectinib
CDK4/6 Related
In Vivo
Models
(1)
Background of CDK4/6 as drug target
- CDK4/6 biology
- Summary of CDK4/6 inhibitors and development stage
(2)
CDK4/6 related CDX models
- MCF-7, xZR-75-1, and xxT47D breast cancer CDX models, validated with Palbociclib or Abemaciclib
- Huh-7 liver cancer CDX model, validated with Palbociclib
- NCI-H2122 and NCI-H358 NSCLC CDX models, validated with Palbociclib or Abemaciclib
- U87-Luc orthotopic brain cancer CDX model, validated with Palbociclib, Ribociclib, and Abemaciclib
(3)
CDK4/6 related PDX models
- LU-01-0393 lung cancer PDX model with CDK4/6 and CCND1 overexpression, p16 deletion, and Rb1 positive, validated with Palbociclib and Abemaciclib
- ES-06-0130 esophageal cancer PDX model with CCND1 overexpression, p16 deletion, and Rb1 positive, validated with Palbociclib and Abemaciclib