Featured Article - Comparing Serial X-ray Crystallography and Microcrystal Electron Diffraction (MicroED) as Methods for Routine Structure Determination From Small Macromolecular Crystals
This article at
IUCrJ by Alexander Wolff (et al.) examines serial X-ray crystallography and microcrystal electron diffraction (MicroED) as useful methods for obtaining structural information from crystals on the nanometre to micrometre scale. While these methods are useful their implementation can often be difficult.
To explore these difficulties, experiments were conducted using XFEL serial crystallography and MicroED.
"The results provide a roadmap for researchers hoping to design macromolecular microcrystallography experiments, and they highlight the strengths and weaknesses of the two methods."
As part of the experiment, crystals were diluted and loaded onto our MiTeGen MicroMesh 700/25.
In case you have extra time on your hands, why not learn or brush up on skills related to what you do? With this in mind we present a list of learning resources ranging from learning Cryo-EM to extracting data from the PDB using Python.
NCCAT Remote Learning Center for Cryo-EM Researchers - Learn more
Rafalab offers online resources useful for learning or teaching data science, biostats and bioinformatics including 15 online courses - Learn more
The electron Cryo-microscopy course from MRC-LMB - Learn more
A Relion 2.0 workshop with Sjors Scheres, hosted by NRAMM and the Simon Electron Microscopy Center - Learn more
Relion 3 new tools for automated high-resolution cryo-EM structure determinations from the SBGrid Consortium - Lean more
Practical Python for beginners - a Biochemists guide - Learn more
EM-learning provides a full cryo-EM SPA course for training users with alternating theory and practical demonstration video - Learn more
ZeroCostDL4Mic - Exploiting Google Colab to develop a free and open source toolbox for deep learning in microscopy - Learn more
Learn to explore the Protein Databank using Python - Learn more
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