Glucagon-Like Peptide 1 (GLP-1) Agonists for Weight Loss: Drug Shortages and Labeled Indications
GLP-1 agonist medications have been approved for the treatment of type 2 diabetes, prevention of cardiovascular disorders in patients with type 2 diabetes, and weight loss.
A rise in social media awareness of GLP-1 agonists as a weight loss solution has led to increased demand. As a result, there has been a national shortage, and patients with type 2 diabetes have had difficulty mantaining treatment.
Semaglutide and liraglutide are GLP-1 agonist medications. Semaglutide has several formulations including Ozempic® (type 2 diabetes), Rybelsus® (type 2 diabetes), and Wegovy® (weight loss). Liraglutide has formulations including Victoza® (type 2 diabetes) and Saxenda® (weight loss). A newly approved medication, Mounjaro® (type 2 diabetes), has emerged as well. Although semaglutide and liraglutide have formulations that are FDA-approved to treat obesity, Mounjaro is only FDA-approved for treatment of type 2 diabetes.
QualChoice records show that Mounjaro has consistently seen the highest number of prior authorization requests each month for the past six months. Requests for Mounjaro have largely been approved with an appropriate diagnosis of type 2 diabetes. Requests for Mounjaro for the treatment of obesity have been and will continue to be denied as this drug is not FDA-approved to treat obesity. There will continue to be a high number of requests for many of these products, often used for weight loss alone, which is a non-covered benefit.
Below is a reference chart for GLP-1 agonist medications. Please evaluate your patients to ensure they are utilizing the medications appropriately and as indicated.
|