QualityCounts.com Newsletter of April 13, 2016
Click here for Past Newsletters
Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice - Front Behav Neurosci. 2016 Feb 9 - "In this study, spatial learning deficits of middle-aged mice were first highlighted and characterized according to their navigation patterns in the Morris water maze task. An eight-week polyphenol-enriched diet, containing a polyphenol-rich extract from grape and blueberry (PEGB; from the Neurophenols Consortium) with high contents of flavonoids, stilbenes and phenolic acids, was then successful in reversing these age-induced effects. The use of spatial strategies was indeed delayed with aging whereas a polyphenol supplementation could promote the occurrence of spatial strategies. These behavioral results were associated with neurobiological changes: while the expression of hippocampal calmodulin kinase II (CaMKII) mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them. Besides, an increased expression of nerve growth neurotrophic factor (NGF) mRNA levels was also observed in supplemented adult and middle-aged mice. Thus these data suggest that supplementation with polyphenols could be an efficient nutritional way to prevent age-induced cognitive decline" - [ Nutra USA] - See blueberry extract at Amazon.com and OPCs+95 at Amazon.com.

Grape skin extract may soon be answer to treating diabetes - Science Daily, 5/9/14 - "grape skin extract (GSE) exerts a novel inhibitory activity on hyperglycemia and could be developed and used to aid in diabetes management ... It is hopeful that our research may eventually lead to the successful development of a safe, targeted nutritional intervention to support diabetes prevention and treatment" - See grape seed extract at Amazon.com .

Grape seed promise in fight against bowel cancer - Science Daily, 2/14/14 - "Our research also showed that in laboratory studies grape seed taken orally significantly reduced inflammation and tissue damage caused by chemotherapy in the small intestine, and had no harmful effects on non-cancerous cells. Unlike chemotherapy, grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected ... The research showed grape seed extract: ... showed no side effects on the healthy intestine at concentrations of up to 1000mg/kg; ... significantly decreased intestinal damage compared to the chemotherapy control; ... decreased chemotherapy-induced inflammation by up to 55% ... increased growth-inhibitory effects of chemotherapy on colon cancer cells in culture by 26%" - See grape seed extract at Amazon.com.

Grape seed and skin extract: A weapon in the fight against kidney disease caused by high-fat diets - Science Daily, 2/28/13 - "Grape seed and skin extract (GSSE) is known to contain powerful antioxidants ... Rats were fed a high-fat diet that induced a low-grade reno-lipotoxicity, that is, kidney damage associated with lipids. This was characterized by elevations in plasma urea and protein in the urine. The researchers found increased deposits of triglycerides (TG) (especially saturated fatty acids), increased signs of oxidative stress and depleted copper levels in the kidneys. There was also histological evidence of disturbance in the kidney structure. When the animals received GSSE at 500 mg/kg bw (which corresponds to 35g/day for a 70 kg human adult) along with the high-fat diet there was a partial reversal of the TG deposition as well as the histological damage. The authors suggest polyphenols including resveratrol are likely the components in GSSE responsible for the positive effects. Furthermore the GSSE prevented the oxidative stress and copper depletion" - See grape seed extract at Amazon.com.

Grape intake may protect against metabolic syndrome-related organ damage  - Science Daily, 4/22/13 -  "Natural components found in grapes, known as polyphenols, are thought to be responsible for these beneficial effects ... The grapes -- a blend of red, green and black varieties -- were provided as a freeze-dried grape powder and integrated into the animals' diets for 90 days ... three months of a grape-enriched diet significantly reduced inflammatory markers throughout the body, but most significantly in the liver and in abdominal fat tissue. Consuming grapes also reduced liver, kidney and abdominal fat weight, compared with those consuming the control diet ... Metabolic syndrome is a cluster of conditions that occur together -- increased blood pressure, a high blood sugar level, excess body fat around the waist or low HDL (the good cholesterol) and increased blood triglycerides" - See grape seed extract at Amazon.com.

As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective, study shows - Science Daily, 1/16/13 - "the more GSE inhibits their growth and survival. On the other end of the disease spectrum, GSE leaves healthy cells alone entirely ... We've known for quite a while that the bioactive compounds in grape seed extract selectively target many types of cancer cells. This study shows that many of the same mutations that allow colorectal cancer cells to metastasize and survive traditional therapies make them especially sensitive to treatment with GSE ... 60 percent of patients diagnosed have already reached the advanced stage of the disease" - See grape seed extract at Amazon.com.

Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed - Science Daily, 1/27/12 - "Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million ... grape seed extract both damages cancer cells' DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51 and DNA repair foci) ... we saw absolutely no toxicity to the mice ... the grape seed extract killed the cancer cells but not the healthy cells" - See grape seed extract at Amazon.com.

Natural chemical found in grapes may protect against Alzheimer's disease - Science Daily, 7/16/11 - "grape seed polyphenols -- a natural antioxidant -- may help prevent the development or delay the progression of Alzheimer's disease ... This is the first study to evaluate the ability of grape-derived polyphenols to prevent the generation of a specific form of ß-amyloid (Aß) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer disease ... administered grape seed polyphenolic extracts to mice genetically determined to develop memory deficits and Aß neurotoxins similar to those found in Alzheimer's disease. They found that the brain content of the Aß*56, a specific form of Aß previously implicated in the promotion of Alzheimer's disease memory loss, was substantially reduced after treatment" - See grape seed extract at Amazon.com.

Grape-seed Extract Kills Laboratory Leukemia Cells, Proving Value Of Natural Compounds - Science Daily, 12/31/08 - "An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract ... They also discovered that the extract does not affect normal cells, although they don't know why" - See grape seed extract at Amazon.com.

Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial - Br J Nutr. 2015 Nov 16 - "grape seed extract (GSE) ... Subjects consumed a juice (167 kJ (40 kcal)) containing 0 mg (Placebo) or 300 mg/d GSE (150 mg) twice daily for 6 weeks ... GSE significantly reduced systolic BP (SBP) by 5.6 % (P=0.012) and diastolic BP (DBP) by 4.7 % (P=0.049) after 6 weeks of intervention period ... GSE significantly reduced systolic BP (SBP) by 5.6 % (P=0.012) and diastolic BP (DBP) by 4.7 % (P=0.049) after 6 weeks of intervention period" - See grape seed extract at Amazon.com.

Grape seed procyanidins in pre- and mild hypertension: a registry study - Evid Based Complement Alternat Med. 2013;2013:313142 - "The efficacy of a standardized grape seed procyanidins extract (GSPE, Enovita) to decrease blood pressure when associated with nondrug intervention (diet and lifestyle modifications) was investigated in a controlled registry study involving 119 healthy, pre- and mildly hypertensive subjects. Two dosages of Enovita were evaluated (150 and 300 mg/die) ... After four months of treatment, a statistically significant higher, and dose-dependent, improvement in all endpoints was observed in the treatment groups compared to that of the control, with blood pressure normalizing in 93% of the higher dosage (300 mg) treatment group. Taken together, these observations suggest that GSPEs have beneficial cardiovascular effects that complement current intervention strategies in the hypertension area. The effect on blood pressure adds to the beneficial effects of GSPEs on the cardiovascular disease (CVD) phenotype associated with the oxidation of membrane lipids (endothelial dysfunction, formation of oxidized LDL, and activation of phagocytic cells)" - See grape seed extract at Amazon.com.

LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers - Int J Food Sci Nutr. 2012 Dec 19 - "A randomized, double-blind, placebo-controlled clinical trial was performed over 56 days and included 60 volunteers. Thirty volunteers took 700 mg of the grape extract, Eminol® (E), and 30 took the placebo (P). On comparison of the results, a decrease in total cholesterol (E: 213.77 +/- 4.1 mg/dl and P: 245.57 +/- 4.1 mg/dl; p = 0.01) and LDL cholesterol (E: 142.17 +/- 3.1 mg/dl and P: 165.13 +/- 3.1 mg/dl; p = 0.02) levels as well as an increase in antioxidant capacity (E: 65.63 +/- 5.8 µmol TE/mg and P: 57.80 +/- 7.7 µmol TE/mg; p < 0.01) and vitamin E (E: 11.46 +/- 0.5 µg/ml and P: 9.06 +/- 0.5 µg/ml; p = 0.018) was observed. This result indicates that the grape extract Eminol® modulated the lipid profile in terms of cardiovascular risk indicators, lowering total blood cholesterol and LDL cholesterol levels" - See grape seed extract at Amazon.com.

Note:  Some say grape seed extract is closely related to Pycnogenol®  but without the patent mark-up.

Pine Bark Extract Found Effective To Naturally Improve Varicose And Spider Vein - prnewswire.com, 10/8/14 - "This study confirms the findings of prior studies that have shown Pycnogenol® effective in strengthening capillary walls making them more resistant against pressure which consequently lowers the release of fluids into tissues. Pycnogenol® has been shown to exert a direct effect on the vein wall. It increases vein tonicity by improving vein resistance and vein elasticity. The extract reduces acute venous swelling and improves venous insufficiency" - [ Nutra USA] - See Pycnogenol at Amazon.com.

Effects of Pycnogenol on Endothelial Function in Stable CAD - Medscape, 8/2/12 - "Recent studies suggested a blood pressure-lowering effect of Pycnogenol. In a double-blind, placebo-controlled cross-over study involving 11 patients, supplementation with Pycnogenol 200 mg q.d. significantly reduced systolic blood pressure of patients with mild-to-moderate hypertension from 139.9 +/- 3.3 to 132.7 +/- 4.18 mmHg (P < 0.05) after 8 weeks of therapy, while diastolic blood pressure remained stable (93.8 +/- 1.23 vs. 92 +/- 1.7 mmHg, P = NS) ... This study demonstrates for the first time an improvement of endothelial function after 8-week treatment with Pycnogenol at a dose of 200 mg q.d. in patients with stable CAD. Pycnogenol significantly reduced oxidative stress as assessed by plasma levels of 8-isoprostanes, but left ADMA and SDMA as well as plasma ET-1 levels unaffected" - See Pycnogenol at Amazon.com.

Pycnogenol May Help Reduce Muscular Cramps and Pain - Medscape, 6/20/06 - "While analog measurements of muscular cramping and pain remained stable in the placebo group during the treatment phase, Pycnogenol significantly improved symptoms"  - See Pycnogenol at Amazon.com.

The COFU3 Study. Improvement in cognitive function, attention, mental performance with Pycnogenol® in healthy subjects (55-70) with high oxidative stress - J Neurosurg Sci. 2015 Dec;59(4):437-46 - "Oxidative stress was comparable in both groups at inclusion. It was significantly decreased with Pycnogenol® (-28.07%; P<0.05) at 12 months; there was no decrease in controls. The short blessed test (SBT) value was significantly increased in controls (P<0.05); but significantly decreased in the Pycnogenol® group ... Pycnogenol® supplementation for 12 months appears to improve cognitive function and oxidative stress in normal subjects between 55 and 70 years of age" - [Nutra USA] - See Pycnogenol at Amazon.com.

French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence - Skin Pharmacol Physiol. 2015 Oct 23 - "the existing data provide compelling evidence that Pycnogenol® intake does not only provide photoprotection, but may be used to (i) reduce hyperpigmentation of human skin and (ii) improve skin barrier function and extracellular matrix homeostasis" - See Pycnogenol at Amazon.com.

Effects of Pycnogenol® on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study - Int Angiol. 2015 Feb;34(1):43-52 - "half of the subjects in each group used 150 mg/day Pycnogenol®. 31 normal subjects were included as control ... This open registry study indicates that Pycnogenol® improves EF in preclinical, borderline subjects in a macro-microcirculatory model. This observation may suggest an important preventive possibility for borderline hypertensive, hyperglycemic and hyperlipidemic subjects" - [Nutra USA] - See Pycnogenol at Amazon.com.

Pycnogenol® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55 - J Neurosurg Sci. 2014 Dec;58(4):239-48 - "Pycnogenol® (150 mg/day) ... Cognitive function, attention, mental performance, sustained attention, memory, executive functions, mood and oxidative stress values were comparable at inclusion. At 12 weeks the improvement in Pycnogenol® subjects was more significant than in controls. Plasma-free radicals (oxidative stress) were significantly decreased (median -30.4%) at 12 weeks in Pycnogenol® subjects in comparison with a non-significant variation observed in controls (+0.9%; difference between groups). Considering the cognitive test battery (PASAT, pattern recognition memory, spatial recognition memory, spatial working memory), Pycnogenol® subjects showed a small but significant improvement with spatial recognition memory unchanged. Mood parameters (alertness, anxiety, contentedness) also improved in professionals using the supplement. In the evaluation of 12 professional daily tasks all items were improved with Pycnogenol® supplementation. The score relative to semi-professional minitasks was improved more in Pycnogenol® subjects. Tolerability and compliance were optimal with >94% of the doses of supplement correctly used" - [Nutra USA] - See Pycnogenol at Amazon.com.

Improvement of common cold with Pycnogenol®: a Winter registry study - Panminerva Med. 2014 Dec;56(4):301-8 - "All subjects used the "best management" for colds and one group added Pycnogenol® capsules (50 mg, bid/die) from day zero. The resulting registry groups were comparable ... The number of days with a perceived cold affecting the patients was reduced in the supplement group (3.1;0.4 days) in comparison with controls (4.2;0.2). Lost working days were significantly decreased in the supplement group (0.55;0.3 versus 0.67;0.3 in controls). The need to use any other compound (on demand basis; OTC products) to manage symptoms and the occurrence of any clinically significant complications were significantly lower in the Pycnogenol® group ... Pycnogenol® supplementation appears to make regression faster for all symptoms in comparison with controls" - See Pycnogenol at Amazon.com.

Evaluation of the effects of supplementation with Pycnogenol® on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the 100-minute triathlon - J Sports Med Phys Fitness. 2013 Dec;53(6):644-54 - "physical fitness (PF) ... Army Physical Fitness Test (APFT) ... divided into 2 parts. In PART 1 (Pycnogenol 100 mg/day), the APFT was used to assess an improvement in PF during an 8-week preparation and training program. In PART 2 (Pycnogenol 150 mg/day), the study evaluated the effects of Pycnogenol supplementation in athletes in training for a triathlon ... Results: PART 1. There was a significant improvement in both males and females in the 2-mile running time within both groups, but the group using Pycnogenol (74 subjects) performed statistically better than controls (73 subjects). The number of push-ups was improved, with Pycnogenol subjects performing better. Sit-ups also improved in the Pycnogenol group. Oxidative stress decreased with exercise in all subjects; in Pycnogenol subjects the results were significantly better. PART 2. In the Pycnogenol group 32 males (37.9; SD 4.4 years) were compliant with the training plan at 4 weeks. In controls there were 22 subjects (37.2;3.5) completing the training plans. The swimming, biking and running scores in both groups improved with training. The Pycnogenol group had more benefits in comparison with controls. The total triathlon time was 89 min 44 s in Pycnogenol subjects versus 96 min 5 s in controls. Controls improved their performing time on average 4.6 minutes in comparison with an improvement of 10.8 minutes in Pycnogenol subjects. A significant decrease in cramps and running and post-running pain was seen in the Pycnogenol group; there were no significant differences in controls. There was an important, significant post-triathlon decrease of PFR one hour after the end of the triathlon with an average of -26.7, whereas PFR in controls increased. In Pycnogenol subjects there was a lower increase on oxidative stress with a faster recovery to almost normal levels (<330 for these subjects). These variations in PFR values were interpreted as a faster metabolic recovery in subjects using Pycnogenol" - See Pycnogenol at Amazon.com.

Pycnogenol® Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome - Phytother Res. 2013 Jan 28 - "In the 6-month study Pycnogenol® supplementation 150mg/day decreased waist circumference, TG levels, blood pressure and increased the HDL cholesterol levels in subjects. Pycnogenol lowered fasting glucose from baseline 123+/-8.6mg/dl to 106.4+/-5.3 after 3months and to 105.3+/-2.5 at the end of the study (p<0.05 vs controls). Men's waist circumference decreased with Pycnogenol from 106.2+/-2.2cm [41.8 inches] to 98.8+/-2.3cm [38.9 inces] and to 98.3+/-2.1 after 3 and 6months. Women's waist decreased from 90.9+/-1.6cm to 84.6+/-2.1cm and to 83.6+/-2.2cm after 3 and 6months. Both genders waist circumference reduction was significant as compared to controls at both time points. In addition, plasma free radicals decrease in the Pycnogenol group was more effective than in the control group (-34.6%; p<0.05)" - See Pycnogenol at Amazon.com.

Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study - Eur Heart J. 2012 Jan 11 - "Patients received Pycnogenol (200 mg/day) for 8 weeks followed by placebo or vice versa on top of standard cardiovascular therapy ... In CAD patients, Pycnogenol treatment was associated with an improvement of FMD from 5.3 +/- 2.6 to 7.0 +/- 3.1 (P < 0.0001), while no change was observed with placebo (5.4 +/- 2.4 to 4.7 +/- 2.0; P = 0.051). This difference between study groups was significant [estimated treatment effect 2.75; 95% confidence interval (CI): 1.75, 3.75, P < 0.0001]. 15-F(2t)-Isoprostane, an index of oxidative stress, significantly decreased from 0.71 +/- 0.09 to 0.66 +/- 0.13 after Pycnogenol treatment, while no change was observed in the placebo group (mean difference 0.06 pg/mL with an associated 95% CI (0.01, 0.11), P = 0.012]. Inflammation markers, platelet adhesion, and blood pressure did not change after treatment with Pycnogenol or placebo. Conclusion This study provides the first evidence that the antioxidant Pycnogenol improves endothelial function in patients with CAD by reducing oxidative stress" - See Pycnogenol at Amazon.com.

Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women - Skin Pharmacol Physiol. 2012;25(2):86-92 - "This study provides skin-physiological and for the first time molecular evidence that Pycnogenol supplementation benefits human skin by increasing skin hydration and skin elasticity. These effects are most likely due to an increased synthesis of extracellular matrix molecules such as hyaluronic acid and possibly collagen. Pycnogenol supplementation may thus be useful to counteract the clinical signs of skin aging" - [Nutra USA] - See Pycnogenol at Amazon.com.

Pycnogenol® supplementation improves cognitive function, attention and mental performance in students - Panminerva Med. 2011 Sep;53 - "In the 8-week study Pycnogenol® supplementation improved sustained attention, memory, executive functions and mood ratings in the students. The improvement was statistically significant. The actual performance on real tests was measured in students undergoing university examinations. The controls failed 9 tests out a total of 84 (10.71%). In the Pycnogenol® group the students failed 7 tests out of 112 (6.25%) with a difference of 4.46% of failures in the Pycnogenol® group that performed, statistically, generally better. The average test score measured by the marks obtained was 23.81 (1.1) in controls vs. 26.1(1.3) (P<0.024) in the Pycnogenol® group" - [Nutra USA] - See Pycnogenol at Amazon.com.

Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition - Panminerva Med. 2011 Sep;53(3 Suppl 1):65-70 - "Pycnogenol® significantly contributed to reduce signs and symptoms associated with menopausal transitions in women investigated in this study. Furthermore, Pycnogenol® improved the quality of life of most women and these benefits may be at least in part attributed to decreased oxidative stress levels" - [Nutra USA] - See Pycnogenol at Amazon.com.

Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction - Phytother Res. 2011 May 27 - "Subjects were instructed to take a supplement (Pycnogenol® 60mg/day, l-arginine 690mg/day and aspartic acid 552mg/day) or an identical placebo for 8weeks, and the results were assessed using the five-item erectile domain (IIEF-5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF-5. In particular, a marked improvement was observed in 'hardness of erection' and 'satisfaction with sexual intercourse'. A decrease in blood pressure, aspartate transaminase and γ-glutamyl transpeptidase (γ-GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with l-arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction" - See Pycnogenol at Amazon.com, l-arginine products at Amazon.com and l-aspartic acid at Amazon.com.
Improvement in cochlear flow with Pycnogenol® in patients with tinnitus: a pilot evaluation - Panminerva Med. 2010 Jun;52 - "These results suggest that in selected patients with tinnitus and altered perfusion, Pycnogenol is effective in a short period of time in relieving tinnitus symptoms by improving cochlear blood flow. The effect is more pronounced with higher Pycnogenol dosage" - [ Nutra USA ] - See Pycnogenol at Amazon.com .
Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study  - J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6 - "evaluated the effects of Pycnogenol as an adjunct to angiotensin-converting enzyme (ACE)-inhibitor ramipril treatment of hypertensive patients presenting with early signs of renal function problems. One group of 26 patients was medicated with 10 mg ramipril per day only; a second group of 29 patients took Pycnogenol in addition to the ACE inhibitor over a period of 6 months ... Urinary albumin decreased from 87 +/- 23 to 64 +/- 16 mg/d with ramipril only. Additional Pycnogenol lowered albumin significantly better from 91 +/- 25 to 39 +/- 13 mg/day (P < .05). In both groups, serum creatinine was lowered; however, only in the combination treatment group did the effect reached statistical significance. In both groups, CRP levels decreased from 2.1 to 1.8 with ramipril and from 2.2 to 1.1 with the ramipril-Pycnogenol combination; the latter reached statistical significance. Kidney cortical flow velocity was investigated by Doppler color duplex ultrasonography. Both systolic and diastolic flow velocities increased significantly after 6 months medication with ramipril. The addition of Pycnogenol to the regimen statistically significantly further enhanced kidney cortical flow velocities, by 8% for diastolic flow and 12% for systolic flow, relative to values found for the group taking ramipril only" - [ Nutra USA ] - See Pycnogenol at Amazon.com.

Pycnogenol((R)) Improves Microcirculation, Retinal Edema and Visual Acuity in Early Diabetic Retinopathy - J Ocul Pharmacol Ther. 2009 Nov 16 - "Results: The major positive observation of this study is the visual improvement, which was subjectively perceived by 18 out of 24 patients in the Pycnogenol group. Testing of visual acuity using the Snellen chart showed a significant improvement from baseline 14/20 to 17/20 already, after 2 months treatment, whereas no change was found in the control group. Conclusions: Pycnogenol taken at this early stage of retinopathy may enhance retinal blood circulation accompanied by regression of edema, which favorably improves vision of patients" - [Nutra USA] - See Pycnogenol at Amazon.com.
Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis - Phytother Res. 2008 Aug;22(8) - "Results show that Pycnogenol in patients with mild to moderate OA improves symptoms and is able to spare NSAIDs" - See Pycnogenol at Amazon.com.

Treatment of osteoarthritis with Pycnogenol((R)). The SVOS (San Valentino osteo-arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects - Phytother Res. 2008 Apr;22(4):518-23 - "The global WOMAC score decreased by 56% (p < 0.05) in the treatment group versus 9.6% in the placebo group. Walking distance in the treadmill test was prolonged from 68 m at the start to 198 m after 3 months treatment (p < 0.05), under placebo, from 65 m to 88 m (NS). The use of drugs decreased by 58% in the treatment group (p < 0.05) versus 1% under placebo. Gastrointestinal complications decreased by 63% in the treatment group, but only 3% under placebo. Overall, treatment costs were reduced significantly compared with placebo ... After 3 months edema decreased in 79% of Pycnogenol patients (p < 0.05) vs 1% in controls" - [Nutra USA] - See Pycnogenol at Amazon.com.

Pycnogenol((R)), French maritime pine bark extract, augments endothelium-dependent vasodilation in humans - Hypertens Res. 2007 Sep;30(9):775-80 - "These findings suggest that Pycnogenol((R)) augments endothelium-dependent vasodilation by increasing in NO production. Pycnogenol((R)) would be useful for treating various diseases whose pathogeneses involve endothelial dysfunction" - See Pycnogenol at Amazon.com.

Treatment of ADHD with French maritime pine bark extract, Pycnogenol - Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35 - "1-month Pycnogenol administration caused a significant reduction of hyperactivity, improves attention and visual-motoric coordination and concentration of children with ADHD. In the placebo group no positive effects were found. One month after termination of Pycnogenol administration a relapse of symptoms was noted. Our results point to an option to use Pycnogenol as a natural supplement to relieve ADHD symptoms of children" - See Pycnogenol at Amazon.com.

Best Naturals Grape Seed Extract 400 mg Veggie Capsule, 120 Count
by Best Nutritionals LLC
Health and Beauty ~ Release Date: 2016-01-18
List Price: $49.99
Our Price: $19.43
Buy Now

Save up to $10 on your first iHerb order.  Use coupon code NAR152.

iHerb now ships to over 190 different countries.  Click here for international rates.

Join Our Mailing List