Novel antioxidant makes old arteries seem young again, study shows - Science Daily, 5/6/14 - "When the research team gave old mice -- the equivalent of 70- to 80-year-old humans -- water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years ... MitoQ completely restored endothelial function in the old mice. They looked like young mice ... Biochemists manufactured MitoQ by adding a molecule to ubiquinone (also known as coenzyme Q10), a naturally occurring antioxidant. The additional molecule makes the ubiquinone become concentrated in mitochondria ... the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice" - See MitoQ at Amazon.com.
Antioxidant drug knocks down multiple sclerosis-like disease in mice - Science Daily, 12/26/13 - "The antioxidant -- called MitoQ -- has shown some promise in fighting neurodegenerative diseases. But this is the first time it has been shown to significantly reverse an MS-like disease in an animal ... the researchers induced mice to contract a disease called experimental autoimmune encephalomyelitis, or EAE, which is very similar to MS in humans ... After 14 days, the EAE mice that had been treated with the MitoQ exhibited reduced inflammatory markers and increased neuronal activity in the spinal cord -- an affected brain region in MS -- that showed their EAE symptoms were being improved by the treatment. The mice also showed reduced loss of axons, or nerve fibers and reduced neurological disabilities associated with the EAE. The mice that had been pre-treated with the MitoQ showed the least problems. The mice that had been treated with MitoQ after EAE also showed many fewer problems than mice who were just induced to get the EAE and then given no treatment" - See MitoQ at Amazon.com.
Antioxidant has potential in the Alzheimer's fight - Science Daily, 12/14/11 - "When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down ... Simply put, that same "browning" process-known as oxidative stress-happens in the brain as Alzheimer's disease sets in ... an antioxidant can delay the onset of all the indicators of Alzheimer's disease, including cognitive decline. The researchers administered an antioxidant compound called MitoQ to mice genetically engineered to develop Alzheimer's. The results of their study were published in the Nov. 2 issue of the Journal of Neuroscience ... Oxidative stress is believed to cause neurons in the brain to die, resulting in Alzheimer's ... The brain consumes 20 percent of the oxygen in the body even though it only makes up 5 percent of the volume, so it's particularly susceptible to oxidative stress ... MitoQ selectively accumulates in the mitochondria" - See MitoQ at Amazon.com.
Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function - J Hypertens. 2013 Dec 4 - "Eight-week-old male stroke-prone spontaneously hypertensive rats (SHRSPs, n=8-11) were treated with low-dose losartan (2.5mg/kg per day); MitoQ10 (500μmol/l); a combination of MitoQ10 and losartan (M+L); or vehicle for 8 weeks. Systolic pressure and pulse pressure were significantly lower in M+L rats (167.1±2.9mmHg; 50.2±2.05mmHg) than in untreated SHRSP (206.6±9mmHg, P<0.001; 63.7±2.7mmHg, P=0.001) and demonstrated greater improvement than MitoQ10 or low-dose losartan alone, as measured by radiotelemetry. Left ventricular mass index was significantly reduced from 22.8±0.74 to 20.1±0.61mg/mm in the combination group" - See MitoQ at Amazon.com.
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