Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials  - J. Pain Research, 4 November 2016 Volume 2016:9 Pages 941-961 -  "oral enzyme combination (OEC) containing proteolytic enzymes and bioflavonoid vs diclofenac (DIC) ... When compared with DIC, OEC showed comparable efficacy and a superior tolerability/safety profile associated with a significantly lower risk of treatment-emergent adverse events, related study discontinuations, and changes in laboratory parameters"  - [ Nutra USA ] - See  Wobenzym at Amazon.com .