Researchers plan to retract landmark Alzheimer's paper containing doctored images

Senior author acknowledges manipulated figures in study tying a form of amyloid protein to memory impairment

June 4, 2024

Science

Charles Pillar

"Authors of a landmark Alzheimer’s disease research paper published in Nature in 2006 have agreed to retract the study in response to allegations of image manipulation. University of Minnesota (UMN) Twin Cities neuroscientist Karen Ashe, the paper’s senior author, acknowledged in a post on the journal discussion site PubPeer that the paper contains doctored images. The study has been cited nearly 2500 times, and would be the most cited paper ever to be retracted, according to Retraction Watch data.

'Although I had no knowledge of any image manipulations in the published paper until it was brought to my attention two years ago,” Ashe wrote on PubPeer, “it is clear that several of the figures in Lesné et al. (2006) have been manipulated … for which I as the senior and corresponding author take ultimate responsibility.'"



Elite researchers in China say they had 'no choice' but to commit misconduct

Anonymous interviewees say they engaged in unethical behaviour to protect their jobs — although others say study presents an overly negative view.

June 11, 2024

Nature

Smriti Mallapaty

"'I had no choice but to commit [research] misconduct,' admits a researcher at an elite Chinese university. The shocking revelation is documented in a collection of several dozen anonymous, in-depth interviews offering rare, first-hand accounts of researchers who engaged in unethical behaviour — and describing what tipped them over the edge. An article based on the interviews was published in April in the journal Research Ethics1.

The interviewer, sociologist Zhang Xinqu, and his colleague Wang Peng, a criminologist, both at the University of Hong Kong, suggest that researchers felt compelled, and even encouraged, to engage in misconduct to protect their jobs. This pressure, they conclude, ultimately came from a Chinese programme to create globally recognized universities. The programme prompted some Chinese institutions to set ambitious publishing targets, they say."



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