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We’re pleased to invite you to attend the 3rd webinar in a 3-part series that showcases important updates and innovations leading up to the 19th International HLA & Immunogenetics Workshop (IHIWS).
Date: Tuesday, December 16, 2025
Time: 10 AM Eastern
Agenda:
- ABO-Histocompatibility - Anne Halpin
- Leukocyte Receptor Complex (LRC) Structure and Polymorphism - Kazuyoshi Hosomichi
- High-resolution KIR sequencing - Jill Hollenbach
- Immunogenetics of type 1 diabetes in world populations - Janelle A. Noble
- Immunogenicity of HLA-DQ antibodies (epitopes) - Anat R. Tambur
Learning Objectives:
ABO–Histocompatibility: By the end of this session, learners will be able to:
- Describe the molecular basis of ABO blood group antigens and their expression on tissues relevant to transplantation.
- Explain the immunologic mechanisms underlying ABO incompatibility and accommodation in solid organ and hematopoietic stem cell transplantation.
- Compare the strategies used to overcome ABO barriers in clinical transplantation.
- Interpret serologic and molecular ABO typing results in the context of histocompatibility testing.
Leukocyte Receptor Complex (LRC) Structure and Polymorphism: By the end of this session, learners will be able to:
- Identify the major gene families located within the human LRC, including KIR, LILR, and Fc receptor genes.
- Explain how LRC gene structure and polymorphism influence innate and adaptive immune responses.
- Discuss the evolutionary significance of LRC variability among individuals and populations.
- Correlate LRC gene polymorphisms with clinical outcomes such as infection susceptibility and transplant rejection.
High-Resolution KIR Sequencing: By the end of this session, learners will be able to:
- Outline the principles and methodologies used in high-resolution KIR sequencing.
- Differentiate between genotyping, copy number analysis, and allelic-level sequencing of KIR genes.
- Evaluate the impact of KIR sequencing resolution on interpretation of NK cell receptor-ligand interactions.
- Apply sequencing data to assess KIR–HLA matching relevance in transplantation and disease studies.
Immunogenetics of Type 1 Diabetes in World Populations: By the end of this session, learners will be able to:
- Summarize the major HLA and non-HLA genetic risk factors associated with type 1 diabetes.
- Compare the genetic architecture of type 1 diabetes across different global populations.
- Explain how population diversity influences disease risk prediction and precision medicine approaches.
- Integrate immunogenetic data to interpret ethnic and geographic differences in disease incidence.
Immunogenicity of HLA-DQ Antibodies (Epitopes): By the end of this session, learners will be able to:
- Describe the structural features and polymorphic determinants of HLA-DQ molecules
- Define epitopes relevant to HLA-DQ antibody formation and immunogenicity
- Assess the clinical significance of HLA_DQ antibodies in graft outcomes and donor selection
This will be an opportunity for you to gain early insights into the 19th IHIWS. We look forward to your participation in this valuable session!
**Attendees will receive 1 contact hour or .15 CEC for attending this webinar**
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