Fall 2025

UCSF Department of Radiation Oncology Logo
The Beam Newsletter. Inspiring the leaders of today and tomorrow.

Message from Our Chair

Dear Alumni, 


Welcome to the Fall 2025 issue of The Beam – our department’s quarterly e-newsletter! It was great seeing many of you at our faculty and alumni reception September 29th at the Proton Therapy site which aligned with the ASTRO conference in San Francisco. We will have photos in our next quarterly issue.


The fall season is well underway! Over the last several months our department leadership and staff have focused on building community and engagement through more in-person touch points and gatherings – for example, through team lunches for small disease site groups, informal coffee & donuts, in-person faculty meetings, and informal Town Halls at our three main campus sites. We find that these moments bring us closer and create space to share ideas, concerns and other issues that may get missed especially as we navigate changes at our institution and nationally. We will continue to host these gatherings and to hope to see you there (some pictures below).

 

We also proudly graduated our medical and physics residents last May and welcomed our 2025-26 incoming class of residents. Please keep up the inspiring, innovative, and hard work!

 

As some of you may be aware, we have been working hard over several years to acquire proton therapy for our cancer patients. This July, the developers of our future Proton Therapy Center broke ground on schedule at the Dogpatch Power Station. We met with our proton therapy equipment manufacturer from Hitachi/Japan and toured the site. Though it will take time, we remain excited about the future new center and vital care and research that will take place to serve our patients and mission.


Warmest regards,

Cathy

Catherine Park Photo

Catherine Park, MD

Professor and Chair




Top News / Announcements

UCSF Cancer Center ready to rise at Power Station — ‘It will set the tone for everything that goes forward’

"The time is right for UCSF, which has been searching for more than a decade for an appropriate site to raise a proton therapy center, according to Dr. Catherine Park, who chairs its radiation oncology department. The treatment more precisely targets cancer cells than conventional therapies, sparing more of the surrounding tissue from radiation; it is especially useful for treating pediatric cancers, Park said, and there are increasing use cases for the treatment among adult patients, too." Read SF Business Times article here

Cancer Stole Her Voice. Curse Words, Children’s Books and AI Saved It

Sue Yom, MD, worked on a collaborative effort with Eleven Labs AI company to recreate the lost voice of a patient - showing the promise of AI voice technology and future research on patients' communiation and quality of life.


Read KQED Article and Listen to the segment here

Research icon

Research

Research Spotlight

Project IMPACT and Computational Cancer Research

Using AI and Medical Informatics to Make Fundamental Cancer Discoveries 


Julian Hong, MD, MS, associate professor, has been awarded by the new Weill Cancer Hub West - a collaboration between UCSF and Stanford - to build artificial intelligence systems that integrate clinical and biological data for precise, personalized cancer treatments. Hong continues to spearhead computational, machine learning and AI-driven research in our department and at UCSF-at-large (Learn more in publications below).


Read SF Examiner story and UCSF Announcement on Project IMPACT/Weill Cancer Hub West

Julian Hong, MD, MS, associate professor, Radiation Oncology, Affiliate Faculty member, Bakar Computational Health Sciences Institute, Core Faculty member, UCSF-UC Berkeley Joint Program in Computational Precision Health

Publications

Tumor heterogeneity underlies clinical outcome and MEK inhibitor response in somatic NF1-mutant glioblastoma

JCI Insight, September 2025; Harish N. Vasudevan


Proton Craniospinal Irradiation for Leptomeningeal Metastases

JAMA Oncology, September 2025; Loren Boreta and David Raleigh


Plasma Proteomic Analysis Reveals Complement System Changes in Irradiated Female BALB/c Mice during Mammary Carcinogenesis

AACR Cancer Research Communications, Aug. 2025; Mary Helen-Barcellos-Hoff et al

One shot at trust: building credible evidence for medical artificial intelligence

The Lancet. Digital Health, Aug 2025; Julian Hong


Considerations in Translating AI to Improve Care

JAMA Network Oncology, April 2025; Julian Hong et al


Novel radiotherapy target definition using AI-driven predictions of glioblastoma recurrence from metabolic and diffusion MRI

NPJ Digital Medicine, August 2025; Steve Braunstein, Olivier Morin, Hui Lin, et al


The climate and health impact of U.S. radiation therapy: estimating greenhouse gas emissions, DALYs, and potential of hypofractionation
Radiotherapy and Oncology, September 2025; Nicolas Prionas, Sue Yom et al


Large language model trained on clinical oncology data predicts cancer progression
NPJ Digital Medicine, July 2025. Hui Lin, Olivier Morin et al


Multi-contrast 4DMR via MR multitasking: Early clinical experience and implication for liver stereotactic body radiation therapy

Radiotherapy & Oncology, May 2025; Wensha Yang


lds and co-occurrence models for individualized risk stratication

Nature Communications, July 2025; David Raleigh, William C. Chen et al


A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system

PNAS, June 2025; Harish N. Vasudevan et al


Multimodal AI Shows No Evidence of Bias in Prostate Cancer Study

Imagine Technology News / JCO Clinical Cancer Informatics, July 2025; Mack Roach III


4D-MRI at 0.55T for internal target volume delineation in liver radiation therapy planning

Medical Physics, August 2025; Jessica E Scholey et al


Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy
Nature Communications, May 2025; Dante P.I. Capaldi, Oliver Morin, et al


Long-Term Clinical Outcomes for Adolescent and Young-Adult Uveal Melanoma Patients Treated with Dedicated Particle-Beam Radiation

Cancers / MDPI, April 2025; Kavita Mishra, Jessica Scholey et al


Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy 

Neuro-Oncology, February 2025, John Liu et al (Epigenetic reprogramming of glioblastoma to overcome chemotherapy resistance, Nature Reviews Neurology highlight on the publication, April 2025)


Here’s How to Prime Tumors to be Defeated by Cancer Immunotherapy
UCSF News story covers the Journal for ImmunoTherapy of Cancer publication, March 2025; Mary Helen Barcellos-Hoff


Perspective: Revisiting the TGFβ paradox: insights from HPV-driven cancer and the DNA damage response
Nature Reviews, May 2025; Mary Helen Barcellos-Hoff and Sue Yom


Real-time lung extraction from synthesized x-rays improves pulmonary image-guided radiotherapy

Physics in Medicine and Biology, January 2025; Ke Sheng

Clinical Trials icon

Clinical Trials

Our department is involved with some of the most important and innovative clinical trials in radiation oncology.


Mary Feng, MD, Vice Chair for Clinical Research

Current Trial Highlights

CC#23722: Wearable Activity Tracking to Curb Hospitalizations (WATCH) PI: Julian Hong

CC#194522 RT-DT : Phase II Trial of Durvalumab (MEDI4736) with/without Tremelimumab for Advanced Hepatocellular Carcinoma after Palliative Hypofractionated Radiotherapy PI: Mary Feng

Other Enrolling Clinical Trials

CC#239814: An Evaluation of Changes in the Relationships Between Fatigue and Molecular Mechanisms in Cancer Patients Receiving Curative-Intent Combined Chemotherapy and Radiation Therapy (CCRT) PI: Sue Yom

CC#24721: An International, Prospective, Open-label, Multi-center, Randomized Phase III Study comparing lutetium (177Lu) vipivotide tetraxetan (AAA617) versus Observation to delay castration or disease recurrence in adult male patients with prostate-specific membrane antigen (PSMA) positive Oligometastatic Prostate Cancer (OMPC) (PSMA-DC) PI: Steven Seyedin

CC#24726: Induction Chemotherapy Response-Guided Radiation for EBV-Associated Nasopharyngeal Carcinoma (NPC) PI: Sue Yom

Tumor-informed ctDNA testing for minimal residual disease monitoring following curative-intent treatment of squamous cell carcinoma of the head and neck (CtDNA) PI: Jason Chan

CC#23721: Two-fraction High Dose Rate Brachytherapy as Monotherapy Delivered Three Hours Apart in Localized Prostate Cancer: A Pilot Study PI: I-Chow “Joe” Hsu

NRG-BN012: A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients with Reselectable Brain Metastases PI: Steve Braunstein

NRG HN006: Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer PI: Jason Chan

CC#24724: A Pilot trial of adjuvant hypofractionated stereotactic radiosurgery for intermediate-risk meningioma (SRS-AIM) PI: William Chen

Welcome icon

Welcome

MD Faculty

William S. Chen

Dr. William S. Chen will joined our Medical faculty on October 1, 2025, as an Assistant Professor and will provide radiation treatment for patients with genitourinary malignancies. He will be located primarily at Mission Bay. Dr. Chen received his MD at Yale School of Medicine, followed by his Radiation Oncology Residency at UCSF. He completed his undergraduate degree in Computer Science at Stanford University. Dr. Chen has a strong research interest in developing and validating biomarkers in prostate cancer using genomics and AI. In his spare time, he enjoys playing tennis, skiing, and listening to live music.


Physics Faculty

Hyeri Lee, PhD

Dr. Hyeri Lee joined our Physics faculty on October 1, 2025, as an assistant professor. She will be located in Mount Zion where she will provide proton ocular service and routine physics coverage for external beam. Dr. Lee received her PhD in physics focusing on building electron accelerators for electron diffraction experiments from Cornell University. She completed her medical physics residency from Harvard Medical Physics Residency Program, then worked at the Ohio State University as a medical physicist and as an Assistant Professor providing external beam services including proton therapy. She contributed to commissioning Varian’s ProBeam 360 proton therapy machine. Dr. Lee has a strong research interest in developing MR-only workflows and utilizing dual energy CT in Radiation Oncology as well as Monte Carlo simulation in proton therapy. Outside of work, she enjoys the outdoors, and fiber arts including knitting and quilting.

Staff

Jae Lee has joined as Chief Radiation Therapist (RTT) in Mission Bay since September 2025. Lee comes to our department with 5-years of Chief Therapist experience, most recently at Stanford.


Alexis Perez joined as an Authorization Coordinator at Mt. Zion in September 2025.


Antonio Huitron joined as a Revenue Cycle Analyst at Mt. Zion in September 2025.


Larissa James joined the Berkeley Outpatient Center as a nurse in August 2025.


Nandar Paing joined in July 2025 as a front desk Practice Coordinator at Mt. Zion.


LaPrea Boudreaux joined in April 2025 as a Front Desk Practice Coordinator at Mission Bay.



Ella Behnke joined Mission Bay as a Medical Assistant in March 2025.


Clarissa Aguirre Luna joined Mission Bay as a Medical Assistant in June 2025.


Stacy Office joined Mission Bay/Parnassus as a nurse in August 2025.


Jennifer Rojas joined the Head and Neck Service as a Nurse Navigator in August 2025.


Jessica Rojas joined the Head and Neck Service as a Nurse Practitioner in September 2025.


Maria Morales joined Mission Bay as a Medical Assistant in October 2025.



Christina Spencer joined Parnassus as a nurse October 2025.

Educational Programs icon

Educational Programs

Miriam Gray, Educational Programs Manager

Dr. Steve Braunstein, MD, PhD, Residency Program Director

Dr. Katelyn Hasse, PhD, Director of Medical Physics Residency Program

Honoring Radiation Oncology Residents Class of 2025

The department hosted a graduation dinner with more than 70 guests in attendance. Graduates included PGY-5 medical residents and R2 physics residents

Medical Residents
: Jie Jane Chen, MD., William Shelton Chen, MD, Katie Lichter, MD, MPH
Physics residents
: Theodore Geoghegan, PhD, Garett Roe, MS

Learn more about Awardees and See Additional Photos

“Graduation is a major milestone to celebrate the transition from trainee to attending physician.”


Catherine Park, MD, Chair, UCSF Radiation Oncology

Welcome New Medical and Physics Residents

The department is also proud to welcome new medical and physics residents for the 2025-2026 academic year!


Other Updates

  • Residents have been helping to host rotating medical students to showcase our department and the satisfaction of training in Radiation Oncology.
  • We are also preparing to enter the application cycle for recruitment of new residents where faculty and residents will host applicants (virtually) over several dates this winter.
  • The department is preparing for Physics recruitment with a virtual residency fair on October 8th and virtual interviews around February of next year.
  • The fall picnic welcoming new residents and faculty will be held in GG Park on October 25th. See the Events section for details!
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Physics Division

First Medical Physics in Imaging and Therapy Research Symposium

The Department of Radiation Oncology at UCSF held its first-ever Medical Physics in Imaging and Therapy Research Symposium last spring. More than 80 participants from the UCSF community and the broader scientific field attended for featured presentations and a scientific poster session showcasing innovative research in medical imaging and therapeutic sciences.

Read article and Learn about Award winners

Updates

Congratulations to Ke Sheng and team for winning first place in the LUMIR Challenge at MICCAI 2025 for "Zero-shot Multi-Contrast Brain MRI Registration by Intensity Randomizing T1-weighted MRI"! MICCAI is the largest international scientific community for medical imaging research. 

For this international competition, participants were asked to train their registration models on T1-weighted brain MR dataset; The evaluation additionally focused on zero-shot tasks that involve substantial domain shifts, such as high-field MRI, pathological brains, and alternate MRI contrasts. The first author Dr. Hengjie Liu was Dr. Sheng's PhD student at UCLA and recently joined UCSF as a post doctoral scholar.


Other updates:

  • Virtual Physics Residency Fair takes place October 8th
  • See some of the latest Physics research papers in Publications and additional honors in Accolades!
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Quality and Safety

embroidery on a shirt that reads be smart about safety

Dr. Emily Hirata, Mary Mok, Nina Pitts, Dr. Nicolas Prionas, Dr. Ke Sheng, Lindsay Williams


Updates and Quality Priorities for 2025-2026

  • We are excited to announce our ACR Re-accreditation (full 3 years)
  • CDPH inspection passed
  • BOPC Launch - the site is doing well with quality oversight.
  • New technologies: The new TrueBeam MLTB4, Cyberknife (CK) for intracranial Stereotactic Radiosurgery (SRS), Real-time Position Management (RPM) breath hold for GI


Enhanced Quality Structure

  • We are pleased to announce new site associate disease site directors will help customize needs for every disease site. Our administrative directors and nurse managers continue to contribute heavily to our quality improvement work.
  • RTT Chief Jae Lee has started in Mission Bay as of September 2025.
    

Patient Pipeline in Development

  • This dashboard tool provides an overview of patients and which stage they are in the treatment process (rolled out initially to dosimetry).
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Operations

closeup image of doctor with stethescope and UCSF logo on jacket


Marina Afable, Dr. Lauren Boreta, Troy Buckmeier, Vernon Cheam, Dr. Emily Hirata, Jae Lee, Amy Miniello, Mary Mok, Nina Pitts, Keisha Nervis, Dr. Nicolas Prionas, Haley Randolph, Karishma Raghuwanshi, Lindsay Williams


Highlights by Location:


Mission Bay

  • In June 2025, the PCMB HDR suite expanded to performing brachytherapy procedures 4 days/week on the 1st and 3rd weeks of the month
  • In August 2025, Bladder Scanning on all machines workflow went live
  • RayStation upgrade completed 8/23/25


Mt. Zion

  • Tomo replacement will kick off 10/31, we will be level loading patients on Versa and at Parnassus 
  • First ADT injections are now being done in the MTZ Infusion Center as of 9/8, this now aligns with MB’s processes 
  • Patients are now able to receive Osteoarthritis treatment as of May
  • Dr. Ashley Manchanda’s new Geriatric service line launched on 7/8
  • HDR volume is shifting from MTZ to MB
    

Parnassus:

  • Treating on both Truebeams (TB4 and STx) as of July 2025
  • The break room is in the process of getting refreshed. The faculty and staff are enjoying a fresh coat of paint, new furniture, and updated appliances. Soon the breakroom storage cabinets will be revitalized.


BOPC:

  • BOPC referral, visit, and treatment volume started picking up in July 2025
  • This clinic is treating a broader variety cases than initially planned and there is an ongoing assessment of the patient population that is able to be treated at BOPC
Accolades icon

Accolades

Large group of people clapping

David Raleigh is a recipient of a UCSF Helen Diller Family Comprehensive Cancer Center Specialized Programs of Research Excellence (SPORE) grant by the National Cancer Institute (NCI) for "Genomic and biochemical mechanisms underlying differences in meningioma outcomes." William C. Chen is a co-investigator for the SPORE grant award "Elucidating interactions between genetic and environmental drivers of prostate cancer outcomes."

Oliver Morin
was recently award an RO1 grant for "Development of a Personalized Voxel-wise Prediction of Brain Metastases using Multi-Parametric MR Imaging to Reduce Treatment Toxicity."


The Radiation Oncology Institute (ROI) announced Sue Yom and Mary Helen Barcellos-Hoff as 2025 Innovation Award Winners - accelerating new indications for RT.


Katelyn Hasse was inducted into the UCSF Academy of Medical Educators.


Congratulations to John Liu and others for the team swim - Swim Across America's swim raised more than $600K at the SF event which benefits glioblastoma and pediatric cancer research. Funds go directly to the UCSF Benioff Children's Hospitals and UCSF Brain Tumor Center.


Two studies from the lab of Hui Lin were awarded by AAPM:
-Best in Physics Multi-Disciplinary: Building a Cross-Modality Model to Integrate Bio-Clinical Features, Anatomical MRI, and White-Matter Pathlength Mapping for Personalized Glioblastoma RT Planning (Bo Liu).

-John R. Cameron Early Career Investigator Symposium Finalist: A Clinically Aligned Embedding Model for Glioma Prognostication Via Radiology-Pathology Report Matching (Benedict Neo).


Harish Vasudevan received the Synergistic Idea Award under the Neurofibromatosis Research Program for “Mapping the RNA Splicing Landscape of NF1 and Its Impact on Neurofibromin Function Across Tissues” through the U.S. Department of Defense Congressionally Directed Medical Research Program (CDMRP)


The first Dr. Felix Feng Young Investigator Award went to Dr. Jeremiah Wala - presented at ASCO 2025 in honor of Dr. Feng's legacy of creating science and commitment to collaboration.

Events icon

Featured Events

Recap! ASTRO's 67th Annual Meeting - Rediscovering Radiation Medicine and Exploring New Indications


ASTRO was held Sept. 27- Oct. 1, 2025 at the Moscone Center in San Francisco. UCSF Press Release


UCSF Radiation Oncology had 40+ sessions/presentations! (Conference Website)

  • Mariana Elia (Hong Lab) was featured in ASTRO abstract highlights  "Machine Learning Holds Promise for Predicting Acute Care Risk" - Elia Elia shows that the previously tested algorithm to reduce ED visits and hospitalizations at UCSF and other medical centers works well at other institutions aiming to improve cancer care delivery and side effect management Read ASTRO article & See post
  • Hui Lin and team's glioma LLM study, "A Clinically Aligned Embedding Model for Glioma Prognostication Via Radiology-Pathology Report Matching," was featured in the Cancer Breakthroughs Session by Todd Pawlicki, president of the American Association of Physicists in Medicine.
  • Faculty connected with academic partners - See daily highlights here
  • Photos from the UCSF Faculty / Alumni reception held at Dogpatch coming soon!

Computational Cancer Community (C3) Monthly Meeting


Monday, December 8, 2025

10 - 11 am

Calendar Link here


Speaker: 

David R. Raleigh, MD, PhD

Associate Professor of Radiation Oncology

Michael McDermott, MD Endowed Professor

Wolfe Family Endowed Professor of Meningioma Research

Translational Meningioma Program Director

Brain Tumor Center Principal Investigator and Preclinical Therapeutics Core Director

HDFCCC Office of Education and Training: Postdoc Professional Development Seminar - NIH Study Section Review Process


Wednesday, November 12, 2025 
3:30pm to 5pm

Details here

Speaker: Mary Helen Barcellos-Hoff, PhD, Wun-Kon Fu Endowed Chair in Radiation Oncology
+ 3 Faculty Panelists

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Coffee Talk

With

Dr. Minsong Cao, PhD

Professor, Division of Physics

Department of Radiation Oncology

Q: What drew you to the field of radiation oncology?

Radiation oncology represents a unique intersection of cutting-edge technology and direct patient care that immediately captivated me. I was first introduced to this field as a graduate student conducting medical imaging research, and I quickly recognized it as the ideal arena where I could apply my physics and engineering background to make a tangible difference in patients' lives. What sets this specialty apart is how we harness sophisticated technology, from advanced imaging systems to precision treatment delivery equipment to fight cancer with remarkable accuracy. The ability to see my technical expertise translate directly into improved patient outcomes is incredibly rewarding and continues to motivate me every day.

Q: What is the most interesting part of your job?

The most fascinating aspect of my work is the personalized medicine approach inherent in radiation therapy. Every patient presents a unique puzzle - different anatomy, tumor characteristics, and medical history, requiring us to develop completely customized treatment plans that maximize therapeutic benefit while minimizing risk to healthy tissue. This individualized problem-solving keeps the work intellectually stimulating and clinically meaningful. Equally rewarding is my role in training the next generation of radiation oncologists, medical physicists, and dosimetrists here at UCSF. Mentoring future professionals and watching them develop their skills to carry forward this vital work adds another dimension of purpose to what I do.

Q: What's the best spot for lunch on campus?

The Hospital Café is my reliable go-to for a quick bite between patients and meetings. When I have more time, Caffe Central is my preferred choice.

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