Ready, Set,
August 14, 2019 | 4.0
Hi Everyone,

We hope you find our new research development grand rounds useful, which will continue on 8/21 with Dr. Bateman convening a panel to discuss “Opportunities for research for full-time Clinicians.”

Are you travelling to a conference but need some family help at home or on the trip? Take advantage of the Family Care Travel Award featured below.

Are you considering submitting a grant? Please reach out to Rachel Abrams ahead of time for a list of required documents and to get the process started.

Have a great rest of the summer,

Danny
Awards & Grants
Deborah Culley
Congratulations to Deb Culley on receiving a grant from National Institutes of Health (NIH) for her project titled “Cognition and the immunology of postoperative outcomes.”

This research study will investigate postoperative delirium in patients 70 years of age or older, undergoing elective primary lower joint replacement or spine procedures.  
Lawrence Tsen
Congratulations to Lawrence Tsen on receiving a BWH Anesthesiology seed grant for his project titled “Investigation of Porcine Epidural and Spinal Spaces: Mechanism of Dural Puncture Epidural (DPE) Technique.”
Charles Serhan
Congratulations to Charles Serhan on recently being recognized as an Expertscape expert in Omega-3 Fatty Acids.

You can view the list of experts in Eicosanoids at this link: http://www.expertscape.com/ex/eicosanoids
"Our Scientists are Working on It"
I deas Requested!
As you may have seen on the rotating flat screens throughout the hospital, Brigham Health has been executing a new research campaign since January of 2019. They are looking for new and exciting material to use for their “ Our Scientists are Working on It ” series.  

They need short, punchy, eye-catching one-liners about BWH research, highlighting the translational impact of their work .

Ex. " Can viruses be used to treat brain cancer? Our scientists are working on it "

Every suggestion posted will highlight the specific investigators working on the issue, so this is nice opportunity to promote our research faculty and the transformative work they are doing .

Please reach out to Claire O'Brien with any questions you may have!
Featured Investigator
Gary Strichartz
Dr. Gary Strichartz is a Professor of Anesthesia at Harvard Medical School and is the Director of the BWH Pain Research Center.

Gary is a very curious person. He was interested in the natural world from childhood, and after earning a bachelor’s degree in Physics from Antioch College, went to graduate school (Biophysics, U Penn) in order to become a teacher at a small, liberal arts college. However, during his doctoral research, which explored the energetics of photosynthesis, he was seduced by the excitement of discovery and decided to make a career in research.

His transition to the neuroscience of pain began in a graduate psychology course when the professor drew a neuron on the blackboard and he wondered about the biophysics of what happens at the neuronal membrane. He was fortunate to have the opportunity to pursue this topic during a postdoctoral fellowship with Bertil Hille, an expert in ion channel biophysics.

Through application of a local anesthetic at the cut end of a nerve fiber, he discovered the direct binding of these drugs and their effect on sodium channel signaling. This led to a desire to better understand the factors that contribute to membrane excitability, including the evaluation of the channel pharmacology of animal toxins, from puffer fish, red tide organisms, Conus snails and scorpions. As Dr. Strichartz began his role at BWH, in 1981, he became more interested in clinically relevant questions, and sensory physiology broadly, looking to bridge the basic to the clinical; from reductionist, single unit nerve testing to understanding animal behavior and the human experience of pain. At BWH he has focused his recent research on the mechanisms of cancer pain and on the induction of acute and chronic post-surgical pain.

A year as an analgesic advisor on the Pain and Palliative Care Team led him to realize the importance of the affective components of the pain experience and drew him to directly caring for patients; chaplaincy, he decided, had the potential to provide this synergy of compassion and care. Therefore, he returned to graduate school, earned a Master of Divinity, and now he practices as a Jewish Unitarian Universalist chaplain at BWH. This combination of skills has led to many collaborations in the areas of: cancer pain (where intra-tumor cannabinoids are used to abolish tumor-related pain,) and the neurobiology of suffering (its physiological and neurochemical mechanisms, as well as developing pharmacological and drug-free methods to reduce such suffering.) In recognition of his research and teaching professor Strichartz was awarded the ASA’s Excellence in Research Award, ASRA’s Gaston Labat Medal, the Stuart Cullen Medal (UCSF) and the Royal Society of Anaesthetist’s Humphrey Davy Medal.

In addition to his research and chaplaincy, Dr. Strichartz is a recognized leader in the field serving on NIH Study Sections, Special Emphasis Review panels, serving on the editorial board of major journals (Anesthesiology, Anesthesia and Analgesia, Regional Anesthesia and Pain Medicine, Neuroscience Letters, Journal of Pain), mentoring over 40 pre- and post-doctoral candidates, and teaching students at Harvard Medical and Dental Schools, as well as MIT. Five of the Anesthesia fellows he has mentored have become department chairs, one a medical school dean.

Dr. Strichartz and his wife Linnea have 6 children together, and 7 grandchildren ranging in age from 3-21. This summer they have embarked on a new project: restoring their 1930’s country lake cottage in Upton, MA.
Post-doc Peer-to-Peer Mentoring Program
Do you know any post-docs who may be interested in a peer-to-peer mentoring program to help broaden their network, learn about the US funding system and options for career paths, improve their biosketch and CV, and more? BWH has a post-doc mentoring circles program to do exactly this! 

Junior post-docs could participate in this program as mentees and more senior post-docs would be eligible as mentors. Registrations for mentees and mentors are currently open. More information on the program and application forms can be found here.

The registration deadline is August 16, 2019.

Contact us for more information at mcp.pda@bwh.harvard.edu !
Department-Wide Research Education Initiative Grand Rounds
Connection LIVE Lunch:
Tips and Tricks to Presenting your research
Date: Monday September 16, 2019
Time : 12:00 - 1:00 PM
Location : Carrie Hall ( 2nd floor "Pike" in the Peter Bent Building near the 15 Francis Street entrance)
Finding Funding
Are you considering submitting a grant?
Please reach out to Rachel Abrams for a list of required documents and to get the process started.

BWH Program for Interdisciplinary Neuroscience
Amount : Up to four 1-year awards of $50,000 each
Deadline : September 15, 2019
Summary : The Program for Interdisciplinary Neuroscience (PIN) aims to engage and help support investigators, physicians and other professionals from across the Brigham community who are focused on understanding and treating disorders of the nervous system. In accordance with the donor’s wishes, one of the awards will be specifically in the field of brain tumors. The other three awards may be in any area of basic, translational, or clinical neuroscience. Please contact Charles Jennings, PhD , with any questions.

Anesthesiology Department Seed funding
Deadline : Rolling
Funding : up to $10,000 
Eligibility : Lecturer, Instructor, Assistant, or Associate Professor at the time of award funding
•   Goal: Support clinical, translational, or basic science research and project development
•   Prerequisites: 
–   Grantee should have a mentoring plan (senior mentor or mentoring team in area of proposed investigation)
–   Grantee should have a career development plan
Up to 5 seed grants will be awarded in 2019. Grant recipients are required to present their work to the Research Leadership Committee before the start of the project and to the Department at the conclusion of their grant.

Family Care Travel Award
Deadline : Rolling
Funding : up to $750 (lifetime limit of 2 awards will apply to each applicant)
The Center for Diversity & Inclusion, with the support of the Brigham and Women’s Physician’s Organization and the Biomedical Research Institute, is pleased to announce the Family Care Travel Award to assist faculty who are caring for a dependent family member at home. The Award will provide financial support to defray some of the costs of traveling with dependents, or extra care at home, while traveling for professional meetings critical to promoting the advancement of early career scholars with familial obligations. 
Helpful Resources
For guidance and advice on the research process and resources, contact Sarah Corey.

For a Department of Anesthesiology Biostatistical consult, please follow this link or send an email to Kara Fields.
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Publications
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE , Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M , Tseng YH.
Cell Metab. 2019 Jul 23. pii: S1550-4131(19)30374-2. doi: 10.1016/j.cmet.2019.07.001. [Epub ahead of print]

ROS-Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy.
Zheng M, Liu Y, Wang Y, Zhang D, Zou Y, Ruan W, Yin J, Tao W , Park JB, Shi B.
Adv Mater. 2019 Jul 26:e1903277. doi: 10.1002/adma.201903277. [Epub ahead of print]

Evidence-based dexamethasone dosing in malignant brain tumors: what do we really know?
Jessurun CAC, Hulsbergen AFC, Cho LD, Aglio LS , Nandoe Tewarie RDS, Broekman MLD.
J Neurooncol. 2019 Jul 25. doi: 10.1007/s11060-019-03238-4. [Epub ahead of print] Review.

Resolution of inflammation: Role of B cells.
Libreros S.
J Leukoc Biol. 2019 Aug;106(2):235-239. doi: 10.1002/JLB.3CE0119-015RR.

Emerging Two-Dimensional Nanomaterials for Cancer Therapy.
Ji X, Guo Z, Ouyang J , Kim NY, Shi J.
Chemphyschem. 2019 Jul 24. doi: 10.1002/cphc.201900551. [Epub ahead of print]

The Growing Challenge of the Older Surgical Population.
Jablonski SG, Urman RD.
Anesthesiol Clin. 2019 Sep;37(3):401-409. doi: 10.1016/j.anclin.2019.04.001. Epub 2019 Jun 14. Review.

A Contemporary Medicolegal Analysis of Injury Related to Peripheral Nerve Blocks.
Saba R, Brovman EY, Kang D , Greenberg P, Kaye AD, Urman RD .
Pain Physician. 2019 Jul;22(4):389-400.

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy.
Luo X, Gu Y, Tao X, Serhan CN , Ji RR.
Front Pharmacol. 2019 Jul 5;10:745. doi: 10.3389/fphar.2019.00745. eCollection 2019.

Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting.
Ngo AL, Orhurhu V, Urits I, Delfin EO, Sharma M, Jones MR, Viswanath O, Urman RD.
Saudi J Anaesth. 2019 Jul-Sep;13(3):231-236. doi: 10.4103/sja.SJA_817_18. Review.

Benefit of regional anaesthesia on postoperative pain following mastectomy: the influence of catastrophising.
Zinboonyahgoon N, Vlassakov K, Lirk P , Spivey T, King T, Dominici L, Golshan M, Strichartz G, Edwards R, Schreiber K.
Br J Anaesth. 2019 Aug;123(2):e293-e302. doi: 10.1016/j.bja.2019.01.041. Epub 2019 Mar 28.

Predictors of Prolonged Opioid Use Following Colectomy.
Fields AC, Cavallaro PM, Correll DJ , Rubin MS, Sequist T, Khawaja A, Yao Y, Bordeianou LG, Bleday R.
Dis Colon Rectum. 2019 Jul 12. doi: 10.1097/DCR.0000000000001429. [Epub ahead of print]

Better Care through Better Measurement: Toward Healthy Mothers and Newborns.
Wanderer JP, Rathmell JP.
Anesthesiology. 2019 Aug;131(2):A15. doi: 10.1097/ALN.0000000000002889. No abstract available.

Obstructive Sleep Apnea and Ambulatory Surgery: Who Is Truly at Risk?
Urman RD , Chung F, Gan TJ.
Anesth Analg. 2019 Aug;129(2):327-329. doi: 10.1213/ANE.0000000000004217. No abstract available.

Update on the pharmacogenomics of pain management.
Kaye AD, Garcia AJ, Hall OM, Jeha GM, Cramer KD, Granier AL, Kallurkar A, Cornett EM, Urman RD .
Pharmgenomics Pers Med. 2019 Jul 3;12:125-143. doi: 10.2147/PGPM.S179152. eCollection 2019. Review.

Rare case of parathyroid gland sarcoidosis presenting with hypercalcaemia.
Saha BK, Burns SL , Foulke LA, Judson MA.
BMJ Case Rep. 2019 Jul 15;12(7). pii: e230598. doi: 10.1136/bcr-2019-230598.

Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review.
Hermanns H, Hollmann MW, Stevens MF, Lirk P , Brandenburger T, Piegeler T, Werdehausen R.
Br J Anaesth. 2019 Jul 11. pii: S0007-0912(19)30501-X. doi: 10.1016/j.bja.2019.06.014. [Epub ahead of print] Review.

Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.
Rao Z, Pace S, Jordan PM, Bilancia R, Troisi F, Börner F, Andreas N, Kamradt T, Menche D, Rossi A, Serhan CN , Gerstmeier J, Werz O.
J Immunol. 2019 Jul 12. pii: ji1900236. doi: 10.4049/jimmunol.1900236. [Epub ahead of print]

Resolvin D4 attenuates the severity of pathological thrombosis in mice.
Cherpokova D, Jouvene CC, Libreros S , DeRoo E, Chu L, de la Rosa X, Norris P , Wagner DD, Serhan CN .
Blood. 2019 Jul 12. pii: blood.2018886317. doi: 10.1182/blood.2018886317. [Epub ahead of print]

Use of a novel non-invasive respiratory monitor to study changes in pulmonary ventilation during labor epidural analgesia.
Kodali BS, Choi L, Chau A, Harvey BC, Brayanov J, Tsen LC , Palanisamy A.
J Clin Monit Comput. 2019 Jul 8. doi: 10.1007/s10877-019-00349-1. [Epub ahead of print]

Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review.
Kaye AD, Motejunas MW, Cornett EM, Ehrhardt KP, Novitch MB, Class J , Siddaiah H, Hart BM, Urman RD .
Curr Pain Headache Rep. 2019 Jul 8;23(8):53. doi: 10.1007/s11916-019-0808-7. Review.

In Response.
Berger M, Angst MS, Culley DJ , Price CE, Scott DA, Whittington RA, Eckenhoff RG; Perioperative Neurotoxicity Working Group.
Anesth Analg. 2019 Jul 2. doi: 10.1213/ANE.0000000000004300. [Epub ahead of print] No abstract available.

Response to Letter to the Editor From Lobo et al.
Susano MJ, Crosby G, Culley DJ .
J Neurosurg Anesthesiol. 2019 Jul 2. doi: 10.1097/ANA.0000000000000621. [Epub ahead of print] No abstract available.

In Response.
Bradley JA, Urman RD, Yao D .
Anesth Analg. 2019 Jun 24. doi: 10.1213/ANE.0000000000004286. [Epub ahead of print] No abstract available.

Utilizing the procedural times glossary as a roadmap to improve efficiency tracking in non-operating room environments.
Wong T, King BS, Boggs SD, Urman RD , Tsai MH.
J Clin Anesth. 2019 Jul 1;59:72-73. doi: 10.1016/j.jclinane.2019.06.029. [Epub ahead of print] No abstract available.

Obstetric Comorbidity and Severe Maternal Morbidity Among Massachusetts Delivery Hospitalizations, 1998-2013.
Somerville NJ, Nielsen TC, Harvey E, Easter SR, Bateman B , Diop H, Manning SE.
Matern Child Health J. 2019 Sep;23(9):1152-1158. doi: 10.1007/s10995-019-02796-3.

Andexanet Alfa for Urgent Reversal of Apixaban Before Aortic Surgery Requiring Cardiopulmonary Bypass: A Case Report.
Flaherty D , Connors JM, Singh S, Sylvester KW, Rimsans J, Cornella L .
A A Pract. 2019 Jun 18. doi: 10.1213/XAA.0000000000001052. [Epub ahead of print]

Impact of Respiratory Compromise in Inpatient Interventional Radiology Procedures with Moderate Sedation in the United States.
Urman RD , Moucharite M, Flynn C, Nuryyeva E, Ray CE Jr.
Radiology. 2019 Jul 2:182455. doi: 10.1148/radiol.2019182455. [Epub ahead of print]

Smartphone Photographs to Document Preoperative Dental Examination.
Stone AB, Aglio LS .
A A Pract. 2019 Jul 1;13(1):37-38. doi: 10.1213/XAA.0000000000001011.

In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy.
Wang Y, Lin YX , Wang J, Qiao SL, Liu YY, Dong WQ, Wang J , An HW, Yang C, Mamuti M, Wang L, Huang B, Wang H.
ACS Nano. 2019 Jul 23;13(7):7568-7577. doi: 10.1021/acsnano.9b00143. Epub 2019 Jul 5.

Poorly Controlled Asthma During Pregnancy Remains Common in the United States.
Cohen JM, Bateman BT , Huybrechts KF, Mogun H, Yland J, Schatz M, Wurst KE, Hernandez-Diaz S.
J Allergy Clin Immunol Pract. 2019 Jun 27. pii: S2213-2198(19)30500-8. doi: 10.1016/j.jaip.2019.05.043. [Epub ahead of print]

GAS, PANDA, and MASK: No Evidence of Clinical Anesthetic Neurotoxicity!
Vutskits L, Culley DJ .
Anesthesiology. 2019 Jun 20. doi: 10.1097/ALN.0000000000002863. [Epub ahead of print] No abstract available.

The Impact of Technology on the Diagnosis of Congenital Malformations.
Straub L, Huybrechts KF, Bateman BT , Mogun H, Gray KJ, Holmes LB, Hernandez-Diaz S.
Am J Epidemiol. 2019 Jun 26. pii: kwz153. doi: 10.1093/aje/kwz153. [Epub ahead of print]

Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes.
Cohen JM, Huybrechts KF, Patorno E, Desai RJ, Mogun H, Bateman BT , Hernández-Díaz S.
J Clin Psychiatry. 2019 Jun 18;80(4). pii: 18m12572. doi: 10.4088/JCP.18m12572.
If you have important information, an update, or announcement that you would like to include in next month's research newsletter, please email your content along with any images, to Sarah Corey .