Ready, Set,
June 27, 2019 | 3.0
Dear Colleagues,

As we head into the summer months, there are a number of events in the research arena that I would like to share with you. 

Our research retreat was a resounding success, with high-profile speakers, good attendance, and some exciting new collaborations (which were funded – see below). Next year’s retreat will be on a Saturday to allow more clinician-investigators to participate.

Our recent funding success as a Department has been thrilling to watch ( 3 FAER, 2 internal Brigham, 1 American Lung Association, 4 Eleanor and Miles Shore Fellows, 2 internal starter grants with education at Harvard School of Public Health, 3 internal seed grants, 2 large NIH awards (to be announced soon)). Below the formal announcements. These are all diverse and innovative proposals, ranging from artificial intelligence to a project improving the environmental impact in the OR to immunotherapy for lung cancer.

I am also excited to announce a new initiative, the department-wide research education sessions . Beginning in July, every 1-2 months the Wednesday morning Grand Rounds will be dedicated to research education and training. From 7-8am, we will have various speakers discuss fundamental research questions, such as study design, IRB, statistics, promotion, academic career development, and publishing. The details are shown below. Then, from 8-9am, our own junior investigators will be presenting their work with the focus on obtaining feedback from experts within our Department and discussing obstacles and how to overcome them.

We also have a new website for both our new and seasoned researchers with the goal of improving the workflow and data infrastructure for research, QAQI, and data analytics projects. The Perioperative Data Group is a one stop shop for all data-related questions, research or QI.

Best

Danny
Awards & Grants
Vesela Kovacheva
"Harnessing the superpower of machine learning to improve patient care during Cesarean Section"
Ehren Nelson
Project aims to create a hands-on, cadaver based simulation approach to learning at the Stratus Simulation Center for interventional pain management trainees.
Angela Nichols
Project aims to create sustainable recycling practices in the operating room, beginning with anesthesia supplies.
Matt Grunert
Project aims to create sustainable recycling practices in the operating room, beginning with anesthesia supplies.
Jinjun Shi
"Combination of p53 mRNA Nanotherapy with Immunotherapy for Liver Cancer Treatment"

Lung Cancer Discovery Award (American Lung Association)
"Tumor Suppressor Restoration Sensitizes mTOR Inhibitor for Lung Cancer"
Alexander Arriaga
"Increasing the Frequency of Debriefing after Perioperative Crises: Altering Trajectories that Impact Provider Burnout and Wellness"
Linda Aglio
Department of Anesthesiology, Perioperative and Pain Medicine Seed Grant
“Predicting and Reducing Post-operative Opioid Consumption and Pain”
Marc Pimentel
Site Director for the HMS Fellowship in Patient Safety and Quality, a CRICO grant.
Research Retreat - Inspired Proposals
Philipp Lirk & Christopher Connor
Department of Anesthesiology, Perioperative and Pain Medicine Seed Grant
“Establishing an instrumented large animal model of compartment syndrome”
Mieke Soens & Pankaj Sarin
Runner-up: Collaborative dinner to discuss proposal
“Development and Validation of a Deep Neural Network Model for Prediction of Severe Acute Post-operative Pain”
Featured Investigator
Kristin Schreiber
As an undergrad, Dr. Schreiber was always interested in the connection between psychology and physiology; both how thoughts impact the body and how signals coming back from the body are received and processed by the brain. To this day, she is fascinated by differences in pain processing between individuals, and that these can be observed through both complex (MRI showing parts of the brain that are active even after a painful stimulus has been removed) and simple (questionnaire or simple bedside pain test) means. Dr. Schreiber’s ultimate goal is to understand and prevent the transition to chronic pain; she is actively working to decrease the activation of nociceptive systems and better understand how to personalize therapeutic approaches. In her translational research lab, she explores this concept using Quantitative Sensory Testing (QST) methods where she is able to probe how pain is sensed and can be modulated. Her primary research focus is on the prevention of post-operative pain, but her research projects also include efforts to build an evidence base for regional anesthetic techniques, investigate alternative therapies for treating chronic pain, optimize breast cancer pain management, and understand gender differences in pain processing. Two years after coming to BWH, she obtained independent NIH K23 funding to complete a longitudinal prospective study of risk of persistent post-mastectomy pain. In 2018, she was the second anesthesiologist in the nation to receive the Maximizing Investigators' Research Award (MIRA; R35) which will provide funding for her lab for the next five years to investigate the different mechanisms underlying development of chronic pain and opioid use after surgery, and how these differ between individuals, across conditions and surgical procedures. 

Dr. Schreiber is an educator, organizing regional and pain journal clubs, and an active mentor to several residents and fellows. In addition, she has been invited to serve on pain management and research task forces including the IMMPACT and ACTTION committees, which develop guidelines regarding clinical research, and the integration of research with clinical practice. Further, she collaborates on several grants with colleagues in surgery, oncology, and emergency medicine, is a member of the Neuropathic Pain Research Consortium and reviews grants for the International Anesthesia Research Society , Canadian Breast Cancer Foundation , the Auckland Medical Research Foundation of New Zealand , and locally for the WHISPR awards . She and her husband Paul have two boys- Leo (14) and Fredrik (12). In their free time they enjoy restoring their 1893 Victorian home, swimming, hiking, running, camping, and going to the beach. Dr. Schreiber is an active member of the Brookline bicycling advisory committee, and is passionate about teaching kids to navigate urban biking safely.
Dear Colleagues, 

I write to announce a new research sundry fund program that will greatly benefit junior and mid-career researcher faculty at Brigham and Women’s Hospital. This new program has been created with the goal of providing a modest level of financial stability for BWH investigators at the Associate Professor level and below who rely on grant funding for their research activities. 

Through this new program, generously funded by Brigham Health President Betsy Nabel, MD and the BWH Department Chairs, investigators who do not currently have sundry fund balances in excess of $50,000 may be eligible for a contribution of up to $25,000 to their sundry fund. Please visit this web page for details. 

The new research sundry fund program will serve as one more pillar in the strong institutional support structure we have here at BWH to enable our investigators and our science to remain competitive in an uncertain funding climate. I am very proud of the research done at BWH and grateful for your collective dedication. I strongly believe that this new program will better position us for continued research successes. 

Regards,

Paul Anderson, MD, PhD
Chief Academic Officer, Brigham Health
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Let the Perioperative Data Group help you with your project! 
Have a question on how to design your research study? Perhaps you need data from our various clinical systems and databases? Or you could use help navigating the study approval process?

The Department has created a “Perioperative Data Group” (PDG) for both our new and seasoned researchers with the goal of improving the workflow and data infrastructure for research, QAQI, and data analytics projects.

The PDG is your one stop shop to conducting your project or research study efficiently and quickly, and can help you at any stage of the project lifecycle. For more information, to ask us a quick question, or to request a consult, visit our website at https://pdg.bwh.harvard.edu . Log in using your Partners username / password from inside the Partners firewall / VPN. 

Feedback on the website and process is greatly appreciated! You can send your feedback to Pankaj Sarin .
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Interesting Article of the Month
Farewell to Morteza Mahmoudi
Dr. Morteza Mahmoudi has been an extremely productive investigator in the Center for Nanomedicine for the past 3 years, rising to the level of Assistant Professor and winning several prestigious awards (IGNITE Award, Connors Center for Women's Health & Gender Biology; BWH, BRIght Future Prize, BWH). He will be leaving BWH on July 1st, to join Michigan State University.

Morteza, we wish you well.
Department-Wide Research Education Initiative Grand Rounds
Finding Funding
Featured Opportunities
Health & Technology Innovation Awards
Deadline: Letters of Intent Due Mon, July 22, 2019
Funding: up to TWO $50,000 awards
Eligibility: Instructor rank and above; professional staff (clinicians, nurses etc); administrative staff (with a letter of approval/support from a direct or indirect supervisor.)
Brigham & Women’s Hospital will host its bi-annual Shark Tank in Oct 2019 to fund innovative and high-risk/high-impact projects in the basic, clinical, digital and translational realms through its Health & Technology Innovation Awards.

McGraw Family Opioid Innovator Awards
Deadline: Letters of Intent Due Mon, July 22, 2019
Funding: ONE $50,000 award & ONE $25,000 award
Eligibility: Instructor rank and above; professional staff (clinicians, nurses etc); administrative staff (with a letter of approval/support from a direct or indirect supervisor.)
The McGraw Family Innovator Awards (open specifically to opioid-related research, ONE $50,000 award & ONE $25,000 award). These awards aim to advance projects that have the potential to make an impact in one or more of the following domains: biomedical research, healthcare delivery, the generation of new companies/products/services, cost savings, care quality and provider burnout among others.

For more information about the awards, follow this link.

Anesthesiology Department Seed funding
Deadline: Rolling
Funding: up to $10,000 
Eligibility: Lecturer, Instructor, Assistant, or Associate Professor at the time of award funding
•   Goal: Support clinical, translational, or basic science research and project development
•   Prerequisites: 
–   Grantee should have a mentoring plan (senior mentor or mentoring team in area of proposed investigation)
–   Grantee should have a career development plan
Up to 5 seed grants will be awarded in 2019. Grant recipients are required to present their work to the Research Leadership Committee before the start of the project and to the Department at the conclusion of their grant.

Family Care Travel Award
Deadline: Rolling
Funding: up to $750 (lifetime limit of 2 awards will apply to each applicant)
The Center for Diversity & Inclusion, with the support of the Brigham and Women’s Physician’s Organization and the Biomedical Research Institute, is pleased to announce the Family Care Travel Award to assist faculty who are caring for a dependent family member at home. The Award will provide financial support to defray some of the costs of traveling with dependents, or extra care at home, while traveling for professional meetings critical to promoting the advancement of early career scholars with familial obligations. 
Publications
Paracetamol versus other analgesia in adult patients with minor musculoskeletal injuries: a systematic review.
Ridderikhof ML, Saanen J, Goddijn H, Van Dieren S, Van Etten-Jamaludin F, Lirk P, Goslings JC, Hollmann MW.
Emerg Med J. 2019 Jun 22. pii: emermed-2019-208439. doi: 10.1136/emermed-2019-208439. [Epub ahead of print] Review.  

Resolvin D1 promotes the targeting and clearance of necroptotic cells.
Gerlach BD, Marinello M, Heinz J, Rymut N, Sansbury BE, Riley CO, Sadhu S, Hosseini Z, Kojima Y, Tang DD, Leeper NJ, Spite M, Barroso M, Rayner KJ, Fredman G.
Cell Death Differ. 2019 Jun 20. doi: 10.1038/s41418-019-0370-1. [Epub ahead of print] 

Anesthesia Type Is Not Associated With Postoperative Complications in the Care of Patients With Lower Extremity Traumatic Fractures.
Brovman EY, Wallace FC, Weaver MJ, Beutler SS, Urman RD.
Anesth Analg. 2019 Jun 17. doi: 10.1213/ANE.0000000000004270. [Epub ahead of print] 

The American Board of Anesthesiology's Standardized Oral Examination for Initial Board Certification.
Sun H, Warner DO, Patterson AJ, Harman AE, Rathmell JP, Keegan MT, Dainer RJ, McLoughlin TM Jr, Fahy BG, Macario A.
Anesth Analg. 2019 Jun 17. doi: 10.1213/ANE.0000000000004263. [Epub ahead of print]  

Moderate and deep sedation training and pharmacology for nonanesthesiologists: recommendations for effective practice.
Tran TT, Beutler SS, Urman RD.
Curr Opin Anaesthesiol. 2019 Jun 18. doi: 10.1097/ACO.0000000000000758. [Epub ahead of print]  

A Stress Test for the Brain: Sedation-induced Deficits.
Wanderer JP, Rathmell JP.
Anesthesiology. 2019 Jul;131(1):A17. doi: 10.1097/ALN.0000000000002853. No abstract available.

Older Adult With Cognitive Impairment Undergoing Ambulatory Surgery: New Epidemiological Evidence With Implications for Anesthesia Practice.
Urman RD, Joshi GP.
Anesth Analg. 2019 Jul;129(1):10-12. doi: 10.1213/ANE.0000000000004184. No abstract available.

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.
Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP.
J Clin Invest. 2019 Jun 17;130. pii: 127282. doi: 10.1172/JCI127282. eCollection 2019 Jun 17.  

The association of body mass index with same-day hospital admission, postoperative complications, and 30-day readmission following day-case eligible joint arthroscopy: A national registry analysis.
Gabriel RA, Burton BN, Ingrande J, Joshi GP, Waterman RS, Spurr KR, Urman RD.
J Clin Anesth. 2019 Jun 11;59:26-31. doi: 10.1016/j.jclinane.2019.06.012. [Epub ahead of print]

A Review of Scientific Literature of Interest to Office-Based Anesthesiology Practitioners.
Saxen MA, Urman RD, Homsi JT.
Anesth Prog. 2019 Summer;66(2):111-114. doi: 10.2344/anpr-66-02-11. No abstract available.

Multivariate resting-state functional connectivity predicts responses to real and sham acupuncture treatment in chronic low back pain.
Tu Y, Ortiz A, Gollub RL, Cao J, Gerber J, Lang C, Park J, Wilson G, Shen W, Chan ST, Wasan AD, Edwards RR, Napadow V, Kaptchuk TJ, Rosen B, Kong J.
Neuroimage Clin. 2019 May 28;23:101885. doi: 10.1016/j.nicl.2019.101885. [Epub ahead of print]  

Commentary: How much hydration is really optimal for the kidneys? How will we know?
Mizuguchi KA, Frendl G.
J Thorac Cardiovasc Surg. 2019 May 2. pii: S0022-5223(19)30941-9. doi: 10.1016/j.jtcvs.2019.04.045. [Epub ahead of print] No abstract available.

Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence.  
Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R; SAGES Study Group; Overall Principal Investigator:.
Anesthesiology. 2019 May 24. doi: 10.1097/ALN.0000000000002729. [Epub ahead of print]

Repeated Cross-sectional Surveys of Burnout, Distress, and Depression among Anesthesiology Residents and First-year Graduates.
Sun H, Warner DO, Macario A, Zhou Y, Culley DJ, Keegan MT.
Anesthesiology. 2019 May 21. doi: 10.1097/ALN.0000000000002777. [Epub ahead of print]  

The American Board of Anesthesiology Staged Examination System and Performance on the Written Certification Examination After Residency.
Zhou Y, Sun H, Macario A, Martin DE, Rathmell JP, Warner DO.
Anesth Analg. 2019 Jun 3. doi: 10.1213/ANE.0000000000004250. [Epub ahead of print]  

Malignant Hyperthermia-Susceptible Adult Patient and Ambulatory Surgery Center: Society for Ambulatory Anesthesia and Ambulatory Surgical Care Committee of the American Society of Anesthesiologists Position Statement.
Urman RD, Rajan N, Belani K, Gayer S, Joshi GP.
Anesth Analg. 2019 Jun 3. doi: 10.1213/ANE.0000000000004257. [Epub ahead of print]


The ultrasound-guided proximal intercostal block: anatomical study and clinical correlation to analgesia for breast surgery.
Zinboonyahgoon N, Luksanapruksa P, Piyaselakul S, Pangthipampai P, Lohasammakul S, Luansritisakul C, Mali-Ong S, Sateantantikul N, Chueaboonchai T, Vlassakov K.
BMC Anesthesiol. 2019 Jun 5;19(1):94. doi: 10.1186/s12871-019-0762-2.  

Identification and Management of Perioperative Anaphylaxis (Grand Rounds Review Article).
Volcheck GW, Hepner DL.
J Allergy Clin Immunol Pract. 2019 May 30. pii: S2213-2198(19)30490-8. doi: 10.1016/j.jaip.2019.05.033. [Epub ahead of print]  

Brachial Plexus Block with Liposomal Bupivacaine for Shoulder Surgery Improves Analgesia and Reduces Opioid Consumption: Results from a Multicenter, Randomized, Double-Blind, Controlled Trial.
Patel MA, Gadsden JC, Nedeljkovic SS, Bao X, Zeballos JL, Yu V, Ayad SS, Bendtsen TF.
Pain Med. 2019 May 31. pii: pnz103. doi: 10.1093/pm/pnz103. [Epub ahead of print]

The Impact of Psychological Interventions on Posttraumatic Stress Disorder and Pain Symptoms: A Systematic Review and Meta-Analysis.
Goldstein E, McDonnell C, Atchley R, Dorado K, Bedford C, Brown RL, Zgierska AE.
Clin J Pain. 2019 May 27. doi: 10.1097/AJP.0000000000000730. [Epub ahead of print]

Racial and ethnic differences in the experience and treatment of noncancer pain.
Meints SM, Cortes A, Morais CA, Edwards RR.
Pain Manag. 2019 May;9(3):317-334. doi: 10.2217/pmt-2018-0030. Epub 2019 May 29.

The neuroinflammatory component of negative affect in patients with chronic pain.
Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML.
Mol Psychiatry. 2019 May 28. doi: 10.1038/s41380-019-0433-1. [Epub ahead of print]

Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations.
Garvey LH, Dewachter P, Hepner DL, Mertes PM, Voltolini S, Clarke R, Cooke P, Garcez T, Guttormsen AB, Ebo DG, Hopkins PM, Khan DA, Kopac P, Krøigaard M, Laguna JJ, Marshall S, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Savic S, Scherer K, Takazawa T, Volcheck GW, Kolawole H.
Br J Anaesth. 2019 Jul;123(1):e50-e64. doi: 10.1016/j.bja.2019.04.044. Epub 2019 May 24.

A medicolegal analysis of positioning-related perioperative peripheral nerve injuries occurring between 1996 and 2015.
Grant I, Brovman EY, Kang D, Greenberg P, Saba R, Urman RD.
J Clin Anesth. 2019 May 22;58:84-90. doi: 10.1016/j.jclinane.2019.05.013. [Epub ahead of print]

Effect of Preoperative Opioid Use on Adverse Outcomes, Medical Spending, and Persistent Opioid Use Following Elective Total Joint Arthroplasty in the United States: A Large Retrospective Cohort Study of Administrative Claims Data.
Blevins Peratikos M, Weeks HL, Pisansky AJB, Yong RJ, Stringer EA.
Pain Med. 2019 May 23. pii: pnz083. doi: 10.1093/pm/pnz083. [Epub ahead of print]

Primary cilia defects causing mitral valve prolapse.
Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA.
Sci Transl Med. 2019 May 22;11(493). pii: eaax0290. doi: 10.1126/scitranslmed.aax0290.

Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain.
Tu Y, Jung M, Gollub RL, Napadow V, Gerber J, Ortiz A, Lang C, Mawla I, Shen W, Chan ST, Wasan AD, Edwards RR, Kaptchuk TJ, Rosen B, Kong J.
Pain. 2019 Jun;160(6):1308-1318. doi: 10.1097/j.pain.0000000000001507.

In Search of Answers and Technology to Better Identify the Bleeding and the Hypercoagulable Patient Phenotype-The Need for Improved Assessment of Deranged Coagulation Beyond Our Current Coagulation Tests.
Frendl G.
Crit Care Med. 2019 Jun;47(6):876-877. doi: 10.1097/CCM.0000000000003754. No abstract available. 

A Contemporary Analysis of Medicolegal Issues in Obstetric Anesthesia Between 2005 and 2015.
Kovacheva VP, Brovman EY, Greenberg P, Song E, Palanisamy A, Urman RD.
Anesth Analg. 2019 Jun;128(6):1199-1207. doi: 10.1213/ANE.0000000000003395.

Maintenance of Certification: Comment.
Cole DJ, Culley DJ, Fahy BG, Warner DO.
Anesthesiology. 2019 Jun;130(6):1091-1092. doi: 10.1097/ALN.0000000000002723. No abstract available. 

Anesthesia without Surgery: Unconsciousness is Metastable.
Wanderer JP, Rathmell JP.
Anesthesiology. 2019 Jun;130(6):A17. doi: 10.1097/ALN.0000000000002768. No abstract available. 

Obstetric Anesthesia: Leading the Way in Patient Safety.
Birnbach DJ, Bateman BT.
Obstet Gynecol Clin North Am. 2019 Jun;46(2):329-337. doi: 10.1016/j.ogc.2019.01.015. Review.

Publisher Correction: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration.
Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L.
Nat Immunol. 2019 Jun;20(6):765-767. doi: 10.1038/s41590-019-0401-6.
Helpful Resources
For guidance and advice on the research process and resources, contact Sarah Corey.

For a Department of Anesthesiology Biostatistical consult, please follow this link or send an email to Kara Fields.
NEW website with BRI Educational videos:
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If you have important information, an update, or announcement that you would like to include in next month's research newsletter, please email your content along with any images, to Sarah Corey .