Rebalancing our Immune System with Agonists

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Interested in learning more about immune agonistic antibodies research?

Immune agonistic antibodies (IAAs) an essential component of future cancer immunotherapy, but challenges such as managing immune-related adverse events need to be addressed. Learn more about IAAs and how it might change the landscape of cancer immunotherapy.

Topics include:

Landscape of IAAs in cancer immunotherapy
Mechanism of Action for Agonists
Specific Targets for IAA Development

B7 Membrane Protein Family

Taking Advantage of Co-signaling to Regulate T Cells

The B7 membrane protein family is a family of proteins that coordinates with CD28 or CTLA-4 to stimulate T cell proliferation and differentiation, or regulating immune responses and inducing antigen-specific tolerances. Depending on the recepter interaction, inhibition or stimulation can be achieved. Explore more about our B7 family to advance your research!

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Trying to find the right B7 member? Explore our table to find the ligand, receptor, and alternative names!

Name	Alt. Name	Binds to
B7-1	CD80	CD28, CTLA-4, PD-L1
B7-2	CD86	CD28, CTLA-4
B7-DC	PD-L2, CD273	PD-1
B7-H1	PD-L1, CD274	PD-1
B7-H2	ICOSLG, CD275	ICOS
B7-H3	CD2765
B7-H4	VTCN1
B7-H5	VISTA
B7-H6	NCR3LG1	NKp30
B7-H7	HHLA2	CD28H

Looking for more B7 family molecules and assay data from ACROBiosystems?

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