SEPTEMBER 16, 2021
Grants Awarded

Extramurally funded research grants awarded to Rogel Cancer Center members

Program Key:
CB - Cancer Biology; CG - Cancer Genetics; CHI - Cancer Hematopoiesis and Immunology; DT - Developmental Therapeutics; HBO - Health Behavior and Outcomes; CEP - Cancer Epidemiology and Prevention; TACR - Translational and Clinical Research
In the Spotlight
New funding relevant to Rogel Catchment Area Priority Cancers and Disparities
John Carethers, M.D., was awarded an R01 ($2.08M) from NCI for “Inactivation of MSH3 in colorectal cancer and race.” (CG)

This project will examine the role and contribution of defective MSH3 protein that likely contributes to the poor phenotype associated with African American CRC patients.
New grants supporting brain cancer
Maria Castro, Ph.D., and Anna Schwendeman, Ph.D., were awarded an R21 ($275K) from NINDS for “Chemo-immunotherapy strategy for pediatric high grade glioma.” (CHI)

This project proposes to deliver olaparib into the TME using high-density lipoprotein (HDL)-mimicking nanodiscs (NDs) that can be specifically internalized into tumor cells via scavenger receptor class B-1 (SR- B1) and caveolae lipid rafts endocytosis.
James Moon, Ph.D., and Maria Castro, Ph.D., were awarded an R01 ($1.6M) from NINDS for “Novel nano-vaccine technology for inducing immunity against gliomas.” (CHI)

This project will address current technical limitations in vaccine technologies and potentially lead to a new treatment option for mIDH1 glioma patients.
Carl Koschmann, M.D., was awarded $378K from the Department of the Defense for “The role of EGFR and FOXG1 in diffuse midline glioma response to mitochondrial targeting drugs.” (TACR)
$100K+ Extramural Grants Awarded in August and September

Thomas Chenevert, Ph.D.: R01 ($2.77M) for “Correction of diffusion gradient bias in quantitative diffusivity metrics for multiPlatform Clinical Oncology Trials.” (TACR)
Yue Cao, Ph.D.: R01 ($1.59M) for “A clinical tool for automated detection and delineation of intracranial metastases from MRI.” (TACR)

Other External Awards

Yatrik Shah, Ph.D.: R01 ($1.63M) from NIDDK for “Control of iron absorption by intestinal HIF2 in iron and hematological disorders.” (CB)

James Moon, Ph.D., and Yu Lei, D.D.S., Ph.D.: R01 ($1.87M) from NIDCR for “New engineering strategy for harnessing immune system against head and neck cancer.” (CHI)

Aaron Udager, M.D., Ph.D.: $100K from the Department of the Defense for “Targeting FOXA1-mediated epigenetic Reprogramming in aggressive salivary gland cancer.” (TACR)
Rogel Cancer Center List of Internal and External Funding Opportunities
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