Minneapolis Heart Institute Foundation

Prevention Research / Nolan Family Center for Cardiovascular Health

September 2025 Semi-Annual Update

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News & Updates

Save the Date for our annual Kevin Grahm Lecture on September 29^th at 7am. Dr. Matt Budoff, Program Director and Director of Cardiac CT at Harbor UCLA Medical Center, will present on Cardiac CT in 2025.
The Nolan Center Team has added a 3rd educational booklet, Heart Healthy Eating on the Go, to its virtual educational library. For more information, visit mplsheart.org/prevention-population-health/patients.

Study Spotlight: TRANSFORM

Description

This study compares two different strategies for preventing complications related to atherosclerosis in individuals with diabetes, pre-diabetes, and metabolic syndrome with no symptomatic cardiovascular disease. Those assigned to usual care receive care based on their CV risk factors while the Cleery coronary artery disease (CAD) stage-based care strategy incorporates imaging-based evaluation for coronary atherosclerosis, algorithm-supported pharmacotherapy and personalized education.

Contact

Daphne Barrera

Daphne.Barrera@allina.com

Principal Investigator

Dr. Michael Miedema

Enrolling Clinical Studies

Study

Study Intervention

PI and Enrolling Sites

TRANSFORM

Cleerly

Cleery CAD stage-based care strategy

Dr. Michael Miedema

ANW and Eden Prairie clinics

Test2Treat

Amgen

Care Champion supplemental education

Dr. Steven Bradley

Dr. Michael Miedema, Co-PI

ANW

Dal-Gene 2

DalCor Pharma

Cholesteryl ester transfer protein (CETP)

Dr. Tom Knickelbine

ANW

DESIFOR EXPAND

MHIF

Patients previously intolerant of statins serve as their own controls while taking blinded placebo/rosuvastatin

Dr. Michael Miedema

ANW, Eden Prairie, Chaska and Edina clinics

Pipeline Studies

MARITIME-CV

Amgen

GLP-1 medication

Dr. Michael Miedema

ANW and Eden Prairie clinics

Abbreviations: ANW= Abbot Northwestern Hospital; ASCVD= atherosclerotic cardiovascular disease; CV= cardiovascular; CAD= coronary artery disease; GLP= glucagon like peptide; LDL= low density lipoprotein; PCSK9= proprotein convertase subtilisin/kexin type 9

For more information, please contact Shannon Clark at Shannon.Clark@allina.com

Interested in clinical trials from our other areas of cardiovascular research? Visit mplsheart.org/archive for any recent emails you may have missed.