Dear Journal Club Attendees-

Please note that the talk originally advertised for December 8th - Dr. Gaston Pfluegl's presentation on making interactive videos and embedding them in CCLE using HTML5 - has been postponed until the Winter quarter. Please find the details of the talk that will be presented in its place this Friday below.


CEILS Special Seminar
Please join us Friday, December 8th to welcome our presenter:
Dr. Alan Garfinkel

Department of Integrative Biology and Physiology
University of California, Los Angeles
2:00-3:00pm | 1100 Terasaki Life Sciences Building [TLSB]
Dynamics in Biology (Points of Contact
between LS30 and LS7)
There are several major points of contact between the quantitative concepts in LS30 and biological topics in LS7. In this talk, we will review the basic approach of LS30, demonstrate the relationship and show applications to three concepts in LS7:
(1)   Moving beyond the “central dogma of molecular biology”.  We teach that the one-way arrows that lead from DNA to RNA, and from RNA to protein, are only a third of the correct picture, and that critical feedback arrows from RNA to DNA (Barbara McClintock) and from protein to DNA (Monod et al.) make for a more complete picture. These feedback loops require mathematical modeling to understand their dynamics.
(2)   lac operon and positive feedback.  An excellent example of feedback loops requiring mathematical modeling is the lac operon, where positive feedback loops controlling gene expression make for a bistable “switch”.
(3)   Oscillations and negative feedback. Negative feedback from protein to gene expression can produce oscillatory gene expression, an important phenomenon (see, for example, 2017 Nobel Prize in Physiology). We will review some oscillatory phenomena, and suggest important revisions of the doctrine of homeostasis.
No RSVP needed. We hope to see you there!
Center for Education Innovation & Learning in the Sciences | UCLA

For more information about CEILS events and resources, including a list of STEM education events from previous mailers, please visit the CEILS website at  or stop by the CEILS offices in Hershey Hall (Rooms 122, 126, 210, and 243).

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