February 25, 2016 
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In This Issue
Look inside the IVBM Virtual Conference Bag
Corporate Partners
Corporate Members
Affiliated Journals
IVBM Supporters
Diamond Level
Welcome Reception Host

Silver Level
Academic Supporters
Bronze Level
Academic Supporter
News You Can Use
HHT Organ and Tissue Samples Available for Research Use
Anatomy Gifts Registry (AGR) recently received an HHT body donation, and the following samples are now available for HHT research:
  • Skin - samples of formalin preserved and frozen lesions, about six total, from hand, L axillary, mid sternum and anterior chest locations
  • Mammary tumor - fixed and frozen
  • Lung Base affected tissue - fixed and frozen
  • Lower lobe of liver affected tissue - fixed and frozen
For more information and to request HHT Tissue: Go to http://curehht.org/medical-scientific/tissue-donation/
Get Involved in NAVBO
Host Vasculata at your Institution
The summer course on vascular biology has been presented at several different institutions including UCLA, Dartmouth, University of Washington, Cleveland Clinic, University of Virginia, University of California, San Diego, University of North Carolina, Chapel Hill, Vanderbilt University and Georgia Tech. The diversity in the settings keeps the course fresh as each institution highlights their own strengths.  Please consider hosting Vasculata at your institution.  Read more . . .

Participate in the Governance of NAVBO
If you are interested in getting more involved with NAVBO, consider running for election on the NAVBO Council. Every year two new Councilors are added and we are seeking volunteers.   Complete an application form . . .

Propose a session for Vascular Biology 2017
We're looking ahead to Vascular Biology 2017 (October 15-19 at the Asilomar Conference Grounds) and we want your input. The NAVBO Council and the meeting organizers (Vicki Bautch, Brian Black, Craig Simmons and Jessica Wagenseil) are seeking proposals from NAVBO members for a new session. This new session may or may not be directly related to the workshop themes. In 2017, we will present the Developmental Vascular Biology and Genetics Workshop and the Vascular Matrix Biology and Bioengineering Workshop. Our goal is to broaden the scope of our meetings, enhance the member experience and respond to our members' interests. To submit your proposal complete this pdf form and email it to info@navbo.org. Submissions are due May 1, 2016.
Welcome to our Newest Corporate Member

We are happy to welcome amsbio to our growing list of Corporate Members.  amsbio will be exhibiting at the 19th International Vascular Biology Meeting.  Be sure to stop by their booth (#18) and thank them for supporting NAVBO.  Visit their web site at www.amsbio.com
Vasculata 2016
August 15-18, 2016

In 2016, we will present the first European Vascu
lata, based in Uppsala, with live web cast to Philadelphia. There will be registration for both sites. The abstract submission sites are now open!  See

19th International Vascular Biology Meeting
The registration and abstract submission sites are now open!!  Save when you register by August 15, 2016.  NAVBO members save even more!  The abstract deadline is July 26, 2016.  Go to www.ivbm2016.org.

Lymphatic Conference in Chicago 2017
June 8-11, 2017
Northwestern University

Vascular Biology 2017
Save the date 
October 15-19, 2017
Asilomar Conference Grounds, Monterey, CA

Vascular Biology, NAVBO's annual meeting, will feature the seventh presentation of the Developmental Vascular Biology and Genetics Workshop and the sixth presentation of the Matrix Biology and Bioengineering Workshop.  
Member News
Welcome our newest member:
Alan Morrison, Yale University

Book chapter by Sriram Ambadapadi, PhD
Dr. Ambadapadi of the University of Florida, Gainesville, has recently published a book chapter:
Ambadapadi, S., Zheng, D., Chen, H., Liu, L., Dai, E., Munuswamy Ramanujam, G., Fortunel, A., Al-Ani, M., Lucas, A.; Serpins, Viruses and the Virome; New Directions in therapy (2015) Ed. The Serpin Family. Proteins with multiple functions in Health and Disease (2015) Springer-Verlag.

If you have news to share with your colleagues, send it to membership@navbo.org.
Product Showcase
Submit your next manuscript to Thrombosis and Haemostasis - International Journal for Vascular Biology and Medicine!

The current average turnaround time from submission to first decision is only 23 days and the Impact Factor 2014 is 4.984.
The following Manuscript categories are accepted for review by the Editorial Board:
Original Articles: Coagulation and Fibrinolysis; Cellular Haemostasis and Platelets; Blood Cells, Inflammation and Infection; Endothelium and Angiogenesis; Cellular Signalling and Proteolysis; New Technologies, Diagnostic Tools and Drugs; Stroke, Systemic or Venous Thromboembolism; and Atherosclerosis and Ischaemic Disease 
Letters to the Editor (incl. Case Reports) 
T&H Images 
Trial Design Papers 
Review Articles (contact Editorial Office before Submission)
Here you can find the instructions and forms for your online submission: http://th.schattauer.de/en/authors/manuscript-submission.html

Spotlight on Trainees (from our 2/11 issue)
Post-doctoral collectives: pathways to a more fruitful experience?
No two post-doctoral experiences are the same, running the gamut of rearview mirror descriptions from "...the best time of my working life..." to an angst-filled "...three years to lay the golden egg." Traditionally relying principally on one's advisor, labmates, and collaborators for support (both material and psychological), post-docs now have dedicated professional organizations in their corners. These include the National Postdoctoral Association and several unions, the first of which ( UAW5810 ) was chartered within the University of California system in 2008. These organizations focus on improving compensation, health care options, benefits, and overall working conditions for post-doctoral workers. As with all matters subject to the ebb and flow of research funding, some question the sustainability of solutions offered through unionization. What say you?
 Recent Publications by NAVBO Members

LDL-Related Intolerance to Glucose, Diastolic Hypertension and Additive Effects of Smoking Were Found with Three Female Study Groups
Scientific Research 

Initial prodiabetic risk profiles were invented here with three female study groups consisting of primarily healthy women (A1: 1990-1999, n = 160; A2: 2009, n = 88; A: n = 248, 36 ± 14 years; B: 2014: n = 65, aged 37± 11 years). Significantly higher blood pressure was found comparing intolerance versus tolerance to glucose (p< 0.05, IGTT, 22 of 68).   Read more


Age-dependent impact of CaV3.2 T-type calcium channel deletion on myogenic tone and flow-mediated vasodilatation in small arteries
The Journal of Physiology 

The myogenic response and flow-mediated vasodilatation are important regulators of local blood perfusion and total peripheral resistance, and are known to entail a calcium influx into vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), respectively. CaV3.2 T-type calcium channels are expressed in both VSMCs and ECs of small arteries.   Read more


Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice
Science Translational Medicine 

Chronic, nonresolving inflammation is a critical factor in the clinical progression of advanced atherosclerotic lesions. In the normal inflammatory response, resolution is mediated by several agonists, among which is the glucocorticoid-regulated protein called annexin A1.   Read more


Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities
Journal of Biological Chemistry 

Serpins regulate coagulation and inflammation, binding serine proteases in suicide inhibitory complexes. Target proteases cleave the serpin reactive center loop (RCL) scissile P1-P1' bond resulting in serpin-protease suicide inhibitory complexes.   Read more


Glycosaminoglycans (GAGs) in Cardiovascular Disease: Searching for the Sweet Spot
Journal of Clinical & Experimental Cardiology 

One of the seminal discoveries in biology was the discovery of the structure of deoxyribonucleic acid, DNA, by James Watson, Francis Crick and Rosalind Franklin that led to the later deciphering of the genetic code by a series of exceptional researchers.   Read more


Job Postings
Job Title
Columbia University
New York, NY
Post-doctoral Fellowship
Medical College of Wisconsin
Milwaukee, WI
Alpert Medical School at Brown and VA Providence
Providence, RI
Assistant/Associate Professor
University of Iowa
Iowa City, IA
University of Oklahoma Health Sciences Center
Oklahoma City, OK
Calendar of Events
Date Event
April 2-6
May 2-3
11th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease
May 25-28
ISTH 62nd Annual Scientific and Standardization Committee Meeting
July 17-22 Endothelial Cell Phenotypes in Health and Disease
Sept. 7-10 ISACB - 15th Biennial Meeting
Nov. 13-16
Industry News (from our 2/11 issue)
Federal budget includes targeted boost for the NIH
President Obama revealed his eighth and final White House budget on Tuesday, Feb. 9, 2016, outlining plans for spending priorities in fiscal year 2017. In the healthcare realm, the president's budget included few surprises. The budget proposal would give the National Institutes of Health $33.1 billion, a 2.6% increase over 2016. The funding would include $680 million for Vice President Biden's cancer initiative; $100 million more for the Precision Medicine Initiative's 1-million person cohort study; and $45 million in added funds for the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative. Aside from these three targeted programs, all of NIH's 27 institutes and centers except the National Cancer Institute would receive no increase compared to FY2016.

Safety of resorbable vascular scaffolds
The Absorb bioresorbable vascular scaffold (BVS) is on par with a traditional everolimus-eluting stent (EES) when it comes to safety (with the exception of a stronger link to target vessel-related myocardial infarction) a meta-analysis of one-year outcomes has found. As reported in The Lancet , recipients of the Absorb BVS and the Xience EES had similar combined rates of mortality, myocardial infarction, and revascularization within 12 months. The authors of the study concluded that "...the aggregate of available evidence supports the safety and effectiveness of BVS at 1 year for treatment of patients with stable coronary artery disease and stabilized acute coronary syndromes."

Vascular growth factors in kidney function
[Bartlett et al. (2016) Annual Review of Physiology] The filtration apparatus of the glomerulus comprises four specialized cell types: fenestrated endothelial cells, podocytes, perivascular mesangial cells, and parietal epithelial cells. A variety of growth factors, notably VEGF, ANGPT, EGF, SEMA3A, TGF-β, and CXCL12, signal in paracrine fashions among these cells to create and maintain filtration barrier function. 

Virally-delivered VEGF-A in microsurgically engineered muscle
[ Moimas et al. (2015) Journal of Tissue Engineering] The authors here report a modification of a published model of tissue engineering, based on an arterio-venous loop encased in a collagen-glycosaminoglycan matrix that serves as an isolated niche for angiogenesis and new tissue formation. A muscular flap harvested from the pectineus muscle was so embedded and transduced by an AAV vector encoding human VEGF-A165. VEGF expression resulted in enhanced tissue formation, with a significant increase in the number of arterioles within the chamber.
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211