October 2016

Here's a recap of blog posts and other news from the past month.

BBC recently ran a program on The Extreme Side-Effects of Antidepressants by Lesley Ashmall on the Victoria Derbyshire programme. ( Here is a link to the program summary and video clip. Here is a link to the  full version  of the video clip.)

While the program was well-received, it is difficult to know what on earth can make a difference when there are close to 30,000 deaths per year in North America from Opioid use, and this has only just begun to elicit serious concern after close to three decades of escalating deaths.

Some of the posts in recent weeks on DavidHealy.org and RxISK.org touch on these issues. RxISK team members also recently published an article in the International Journal of Risk and Safety in Medicine, entitled  Links between serotonin reuptake inhibition during pregnancy and neurodevelopmental delay/spectrum disorders that provides the background for the Autistic Spectrum Disorder and SSRIs blog post on RxISK.

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David Healy, MD

RxISK stories

Five years ago, the Croen et al article in the Figure above appeared suggesting that antidepressant use in pregnancy can cause Autistic Spectrum Disorder (ASD). Pharmaceutical companies rushed to manage the risks - to them. What you do is you convene your experts and you put them in boxes, a teratology box, an animal studies [...]...»

Further excerpts from Bruce Springsteen's Born to Run. Bruce looks like he had a dependence syndrome and perhaps even organic damage or dysfunction linked to an antidepressant - See Born to Withdraw. Did he also have akathisia? Akathisia (restlessness, agitation & turmoil): A disorder characterized by an uncomfortable feeling of inner restlessness and inability to [...]...»


These excerpts from Bruce Springsteen's new book Born To Run were picked out for us by a colleague who is a lifetime Bruce fan. Zero to sixty in nothing flat The blues don't jump right on you. They come creeping. Shortly after my sixtieth I slipped into a depression like I hadn't experienced since that [...] ...»

Dr. David Healy
From David's blog...

Harold Shipman was a doctor in Britain, who was arrested for murder in 1998. He turned out to be a true Angel of Death, the most prolific known serial killer, who killed it is thought between two and three hundred of his patients by prescribing opioids in large doses. After his trial and conviction and [...]...»

This post merges the Go Figure sequence of posts from several weeks ago with the 329 series. In the wake of the French Revolution of 1968, the government was still tottering when on February 4 1970, sixteen miners died with twelve others maimed in an explosion at a mine in Lens in France. The [...] ...»


It was tempting not to run a post today for fear it might get lost in the wash of the Clinton-Trump debate. But today is the fourteenth anniversary of the day FDA issued an approvable letter for Paxil for children, as well as the fifty-fourth anniversary of the 1962 FDA Act that created [...] ...»


We interrupt the Go Figure series of posts to return for two posts to Study 329. We will then return to Go Figure. All the fuss about Study 329 centers on its 8 week acute phase. But this study had a 24 week Continuation Phase that has never been published. Until Now. We might [...] ...»