SBP Discoveries
Dear Colleagues,

This February issue of SBP Discoveries introduces you to our research contributions in muscular dystrophy, heart disease, cancer and autoimmune disease. We've also highlighted news about SBP people and events. 

We welcome your input. Please drop us a line anytime.

Wishing you all the best,
SBP Communications
Sanford • Burnham • Prebys
SBP Discoveries
Monthly Newsletter  •  February 2016
Structure of immune-regulating ubiquitin ligase solved

New research from the lab of Stefan Riedl, Ph.D., associate professor in the Cancer Metabolism and Signaling Networks Program, has revealed the atomic structure of HOIP, a unique ubiquitin ligase. The findings, published in Nature, open the door to develop a new class of drugs for cancer and inflammatory diseases.

Select Media Coverage: Science Codex, Science Daily
Science News
Pinpointing the components needed to regenerate muscle

Research from the lab of Pier Lorenzo Puri, M.D., resolves deep-rooted conflicting data on the proteins that control the genes needed to repair skeletal muscle. The study was published in eLife.

Failing hearts switch fuels to generate energy

A new study published in Circulation by Daniel Kelly, M.D., provides fresh molecular insight into heart failure and may eventually lead to new therapeutic targets to prevent or slow progression of the disease.

Why new therapies are failing some kids with brain cancer

Robert Wechsler-Reya, Ph.D., director of the Tumor Initiation and Maintenance Program, co-authored an international collaborative study published in Nature describing why so many targeted drugs for medulloblastoma fail in clinical trials.

Read more on Beaker >>

New insight on T cells that promote autoimmune disease

Fraydoon Rastinejad, Ph.D., professor in the Integrative Metabolism Program, co-authored research published in Nature on how a recently discovered type of T cell  (TH17) evolves and contributes to inflammation and autoimmune diseases.

Read more on Beaker >>

Towards a more sensitive and specific diagnostic test for melanoma

Ranjan J. Perera, Ph.D., associate professor and scientific director of the Analytical Genomics and Bioinformatics core facility at SBP, is making headway on an improved diagnostic test for melanoma. The new approach, published in Molecular and Cellular Biology and the Journal of Investigative Dermatology, measures non-protein coding RNA levels in tumor biopsies.

Our People
Ze'ev Ronai receives Outstanding Investigator grant

Ze’ev Ronai, Ph.D., scientific director of SBP's La Jolla campus, has received one of 50 Outstanding Investigator Awards from the NCI.  

Randal Kaufman among world's most influential biologists

Thomson Reuters has announced the world's most influential scientific minds, and for the second time since 2014, Randal Kaufman, Ph.D., professor and director of SBP's Degenerative Disease Program, is on that list. 

Select Media Coverage: UT San Diego
SBP's Garth Powis talks about the search for a cure for cancer

The search is on for a new generation of cancer drugs, and Garth Powis, D. Phil., head of the NCI-designated Cancer Center at SBP, appeared on KUSI news in San Diego to talk about recent treatment breakthroughs and what's to come for treating this often deadly disease. 

SBP graduate student Victoria Thaney's internship at Illumina

Congratulations to Victoria Thaney, who was chosen for an internship at Illumina. The company is a leader in sequencing technologies and was named the world's smartest company by MIT Technology Review in 2014.

Welcome to our newest and recently renewed President's Circle Members!
Julie and George Bronstein  •  D Bar  •  Dr. Harsh Karandikar, Ph.D.  •  Michael P. Sampson  • Kathleen A. Wachter  •  Bebe Zigman  •  Rupa and Harsh Karandikar
President's Circle
Please Donate
SBP at the Reuben H. Fleet Science Center stem cell exhibit

Pamela Itkin-Ansari, Ph.D., adjunct assistant professor in the Development, Aging, and Regeneration Program at SBP, participated in the grand opening event for the Super Cells exhibit at the Fleet on Jan. 28.

SBP's Rare Disease Day in La Jolla

On February 26-27, SBP will host its 7th annual Rare Disease Day symposium and workshop. The theme, human glycosylation disorders, will attract scientists, physicians, patients and their families working to improve the lives of affected children.

Read more on SBP's website >>
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