- Bacopa monnieri (L.) (BM) is widely used in traditional ayurvedic medicine.
- Active molecules of BM have potential neuroprotective and memory boosting ability.
- Neuroprotection of BM via oxidative stress mitigation, mitochondrial dysfunction.
- Learning and memory action are enhanced by the active constituents of BM.
- This review highlights neuropharmacological and cognitive effects of BM.
(L.) – (BM) is a perennial, creeping herb which is widely used in traditional ayurvedic medicine as a neural tonic to improve intelligence and memory. Research into the biological effects of this plant has burgeoned in recent years, promising its neuroprotective and memory boosting ability among others. In this context, an extensive literature survey allows an insight into the participation of numerous signaling pathways and oxidative mechanism involved in the mitigation of oxidative stress, along with other indirect mechanisms modulated by bioactive molecules of BM to improve the cognitive action by their synergistic potential and cellular multiplicity mechanism. This multi-faceted review describes the novel mechanisms that underlie the unfounded but long flaunted promises of BM and thereby direct a way to harness this acquired knowledge to develop innovative approaches to manipulate its intracellular pathways.