Editor's Note
The findings presented in this study are consistent with previous evidence suggesting that the oral administration of CBD in a corn oil formulation is a safe route for the administration of the active substance without bioconversion to THC in humans under different conditions (fasting and normal feeding). The results also add to the knowledge built over 40 years of research that CBD-based therapies are safe and well tolerated in humans. Finally, these results may have clinical and forensic implications considering the potentially toxic effects of THC and other cannabis constituents, including cognitive impairment and chronic psychiatric disturbances, especially in younger patients who might be more prone to potential long-term harmful effects of the substance on their developing brains.

The main results of our study show that a standard clinical dose of CBD in corn oil formulation did not convert into THC in humans under fasting and normal feeding conditions. We found no signs of Δ8-THC or Δ9-THC in whole blood at 3 and 6 h after oral administration of CBD. The findings are supported by the results of previous, methodologically adequate animal studies using oral CBD. In a study with male rats (Sprague Dawley), oral CBD (50 mg/kg) dissolved in olive oil and ethyl alcohol was administered, and the animals were sacrificed after 3 or 6 h. Despite the use of a highly sensitive and selective LC-MS/MS method, the authors found no signs of Δ9-THC or its metabolites (11-hydroxy-D9-tetrahydrocannabinol [11-OH-THC], THCCOOH, and THCCOOH-gluc) in whole blood at 3 or 6 h after oral CBD. The possibility of the conversion of CBD to Δ9-THC has also been investigated in minipigs, which is considered a suitable animal model for the human gastrointestinal tract. Synthetic CBD (15 mg/kg) dissolved in sesame oil was administered by gavage to male minipigs twice a day for 4 days, and blood samples were collected from the jugular vein on days 1 and 5, just before, and 1, 2, 4, and 6 h after CBD administration. No detectable levels of both Δ9-THC and 11-OH-THC were found in any of the plasma samples collected.

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