Editor's Note
This study investigates the ameliorative effect of salidroside (SAL) from  Rhodiola Rosea L. on the  intestinal microflora  subject to furan-induced  liver injury  in a  mouse model . The authors found that SAL supplement restrained intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan. The study concludes that SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases.
In our study, the ameliorative effect of salidroside (SAL) from  Rhodiola Rosea L. on the  intestinal microflora  subject to furan-induced  liver injury  in a  mouse model  was investigated by 16 S  rDNA , oxidative indexes, LPS and cytokine levels. The results demonstrated that SAL alleviated hepatic oxidative injury by inhibiting the activities of AST, ALT and the content of  MDA , and promoting the activities of SOD, GSH and GST, compared to the furan-treated group. SAL significantly modified the intestinal microbial diversity and downregulated the circulating levels of serum LPS, IL-6, and  TNF-α , as well as enhanced the content of IL-10. Importantly, SAL dramatically increased LPS-suppressing bacteria genera Akkermansia, and decreased LPS-producing bacteria phyla  Proteobacteria . Our results indicate that SAL supplement restrains intestinal microbial  dysbiosis  and systemic low-grade inflammation induced by  furan . Hopefully, SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases.