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Washington, DC (23 April 2026) – The Society of Interventional Oncology (SIO) is pleased to announce the start of patient enrollment at Mayo Clinic in Rochester, Minnesota, for TRIBUTE: A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated with Percutaneous Ablation and Palliative Radiation Therapy. The Mayo Clinic in Rochester site is principal investigators are Brian Welch, MD, Sean Park, MD, and Jonathan Morris, MD.
The TRIBUTE study clinical leadership includes Jack Jennings, MD, PhD, and Clifford Robinson, MD, at Washington University School of Medicine, St. Louis, and Sean Tutton, MD, and James Urbanic, MD, at University of California, San Diego. “Each new participant brings us closer to understanding how combined percutaneous ablation and palliative radiation can improve outcomes for patients with high-risk bone metastases,” said Jennings. “We look forward to additional sites beginning patient enrollment later this year.”
The TRIBUTE study is collectively supported by the study’s Exclusive Pioneer Trial Partner, Varian, a Siemens Healthineers Company, the study’s Catalyst Trial Partner, Stryker, Inc., and the study’s Advocate Trial Partner, Boston Scientific Corporation.
This is the first prospective, multi-center study to evaluate real-world outcomes (e.g., pain, patient-reported outcomes, skeletal-related events, healthcare utilization, etc.) in adult patients treated with both percutaneous ablation and palliative radiation therapy (RT) for symptomatic, high-risk metastatic bone lesions. The study was collaboratively designed and developed with the partnership of radiation oncology, which SIO sees as a critical multidisciplinary partner to the success of the study. Upon completion, the study will enroll 120 subjects from across sites in the U.S.
Percutaneous ablation and RT have different mechanisms of alleviating pain and causing tumor death that may work synergistically. Radiation therapy is a widely accepted treatment for painful bone metastases and provides palliation of pain for patients. Percutaneous ablation, a minimally invasive therapy for painful metastatic bone disease, can be performed with thermal modalities (e.g., radiofrequency, microwave, cryoablation) and requires minimal recovery.
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About the Society of Interventional Oncology (SIO)
SIO serves as the only membership-based organization dedicated to the emerging field of interventional oncology (IO), working to establish, nurture, and support IO as the fourth pillar of cancer therapy alongside medical, surgical, and radiation oncology worldwide. IO therapies, such as embolization and tumor ablation, combine the expertise of oncology and radiology and use imaging technology to diagnose and treat localized cancers in ways that are precisely targeted and minimally or non-invasive. For more information, please visit www.sio-central.org.
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