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Scan Times

An MGH Radiology Research Newsletter

June 2023

We are always on the lookout for new ways to bolster the sense of community among you and your colleagues in the department. The newsletter you are now holding in your virtual hands is an example of this: our hope with Scan Times is to encourage discussion and even collaboration among research faculty, fellows, students and staff.


Now, we are pleased to announce a corresponding Scan Times website: scantimes.mgh.harvard.edu. Like the newsletter, the site collects articles about Radiology Research from across the hospital. Here, though, you can easily refer back to the articles without having to dig through your mailboxes, all the while mumbling to yourself about the mountains of email you receive every day.


Maintaining a website also gives us more opportunity to develop original content about all the excellent work you're doing, like the Q&As you've seen in this space in recent months. To mark the launch of the Scan Times website, we are excited to share an article looking at the early days of the X-ray in Boston, at the wave of excitement and occasional trepidation that swept the city in the weeks and months after news of the discovery reached our shores. Check out "When the X-Ray Was Young, and a Little Bit Scary (Part 1)." (See below for more about the article.)


Speaking of community, we have also included on the website resources to help you learn about your colleagues and their work. The Researchers page offers descriptions of the major research centers and institutes in the department (please let us know if we've missed anything!) as well as links to Find a Researcher and Harvard Catalyst, where you can explore individual investigators' research interests, publications, etc.


The page also connects you with a relatively new initiative in the department. Spearheaded by Marc Succi, MD, and Miriam Bredella, MD, MBA, MentorMGB. serves as a kind of “LinkedIn” for the MGB community, connecting faculty and opening opportunities for collaboration, general discussion, etc. Read more about (and sign up for!) MentorMGB below.

Bruce Rosen, Vice-Chair for Research

In This Issue

A 'LinkedIn' for the MGB Community

2024 Clinical Trials Methodology Workshop

When the X-Ray Was Young, and a Little Bit Scary (Part 1)

Detecting ‘Covert Consciousness’ in Patients with Severe Brain Injury

Editorial: Radiology 2040

Review: Recent Developments and Future Trends in Thoracic Radiology

Select Publications from May 2023

A 'LinkedIn' for the MGB Community

Now online is a department-wide mentoring and research collaboration website: MentorMGB. Think of it as “LinkedIn” for the MGB community, connecting faculty across hospitals for finding and giving secondary mentorship, collaborating on research interests/finding new projects, and general work and non-work discussion / connections. The hope to foster a dynamic cross-institution mentorship culture and facilitate research collaborations.


The platform also includes a research project directory, where investigators can place "ads" for student help for research projects and allow students, residents, and collaborators to contact them through MentorMGB.org without ever revealing their email.


First-time log-in Instructions:

• Click here to login: www.mentormgb.org

• Click “create an account" and fill out the relevant details using your MGB email (@mgh/bwh.harvard.edu NOT @partners.org). For example: msucci@mgh.harvard.edu. If you don't remember your password, click on "Forgot Password."


Please email msucci@mgh.harvard.edu with any issues. As some emails/aliases have changed over time, your email may need to be updated in the system.


Read more about the platform in a recent paper published in the Journal of the American College of Radiology: "A Scalable Mentoring Web Platform Deployed in a Large Academic System: Pilot Implementation."

2024 Clinical Trials Methodology Workshop

Applications are now being accepted for the Clinical Trials Methodology Workshop to be held Jan. 6–12, 2024 in Jupiter, FL, USA. Submission deadline is July 1, 2023. Sponsored by the RSNA, this workshop is Intended for early- or mid-career academics (MD or PhD) in diagnostic or interventional radiology, radiation oncology, nuclear medicine, or medical physics. Students work with senior faculty in the imaging and data sciences in small group and one-on-one sessions to develop the skillsets needed to lead clinical trials. The application site is here. A description of last year’s program, faculty, and students are hereSusanna Lee, MD, PhD (slee0@mgh.harvard.edu) is the organizer for this year’s workshop. Fiona Miller, RSNA (dor@rsna.org) can assist with the application process.

When the X-Ray Was Young, and a Little Bit Scary (Part 1)

Reports of a 'new invisible light' in the early days of 1896 sparked a kind of X-ray fever in Boston. Here, we explore the different ways people in the city and surrounding areas reacted to the discovery, as described in contemporaneous newspaper reports as well as in other sources: from physicists quickly recreating Röntgen's original experiments to humorists worrying about the technology revealing skeletons in everyone's closets --- and finally to an apothecary and his assistant introducing X-ray imaging at Massachusetts General Hospital. Read more here.

Detecting ‘Covert Consciousness’ in Patients with Severe Brain Injury

With funding from an MGH Research Scholar award, the Martinos Center's Brian Edlow, MD, will lead a team in optimizing and implementing novel imaging technologies for this critical application. Read more here.

Editorial: Radiology 2040

Radiologist-in-chief James A. Brink, MD, and a colleague urge radiologists to prepare for “seismic” changes in health care by adding value beyond image interpretation, with special attention to how artificial intelligence will affect practice and the need to offer precision imaging, image-guided intervention, and radiotheranostics. Read more here.

Review: Recent Developments and Future Trends in Thoracic Radiology

Theresa C. McLoud, MD, senior advisor for faculty affairs in the department, and a colleague explain how the advent of artificial intelligence and quantitative thoracic imaging, and improvements in hardware and its applications, are expected to lead to more accurate diagnosis and better treatment. Read more here.

Select Papers from May 2023

1: Bahl M. The Quest to Reduce the Use of Gadolinium-based Contrast Agents: AI May Provide a Solution. Radiology. 2023 May;307(3):e230325. doi: 10.1148/radiol.230325. Epub 2023 Mar 21. PMID: 36943082; PMCID: PMC10140636.



2: Billot B, Greve DN, Puonti O, Thielscher A, Van Leemput K, Fischl B, Dalca AV, Iglesias JE; ADNI. SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining. Med Image Anal. 2023 May;86:102789. doi: 10.1016/j.media.2023.102789. Epub 2023 Feb 25. PMID: 36857946; PMCID: PMC10154424.



3: Chemli Y, Tétrault MA, Marin T, Normandin MD, Bloch I, El Fakhri G, Ouyang J, Petibon Y. Super-resolution in brain positron emission tomography using a real- time motion capture system. Neuroimage. 2023 May 15;272:120056. doi: 10.1016/j.neuroimage.2023.120056. Epub 2023 Mar 26. PMID: 36977452; PMCID: PMC10122782.



4: Cohen KW, De Rosa SC, Fulp WJ, deCamp AC, Fiore-Gartland A, Mahoney CR, Furth S, Donahue J, Whaley RE, Ballweber-Fleming L, Seese A, Schwedhelm K, Geraghty D, Finak G, Menis S, Leggat DJ, Rahaman F, Lombardo A, Borate BR, Philiponis V, Maenza J, Diemert D, Kolokythas O, Khati N, Bethony J, Hyrien O, Laufer DS, Koup RA, McDermott AB, Schief WR, McElrath MJ. A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses. Sci Transl Med. 2023 May 24;15(697):eadf3309. doi: 10.1126/scitranslmed.adf3309. Epub 2023 May 24. PMID: 37224227.



5: Corona L, Tamilia E, Perry MS, Madsen JR, Bolton J, Stone SSD, Stufflebeam SM, Pearl PL, Papadelis C. Non-invasive mapping of epileptogenic networks predicts surgical outcome. Brain. 2023 May 2;146(5):1916-1931. doi: 10.1093/brain/awac477. PMID: 36789500; PMCID: PMC10151194.



6: Coughlan GT, Betthauser TJ, Boyle R, Koscik RL, Klinger HM, Chibnik LB, Jonaitis EM, Yau WW, Wenzel A, Christian BT, Gleason CE, Saelzler UG, Properzi MJ, Schultz AP, Hanseeuw BJ, Manson JE, Rentz DM, Johnson KA, Sperling R, Johnson SC, Buckley RF. Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography. JAMA Neurol. 2023 May 1;80(5):462-473. doi: 10.1001/jamaneurol.2023.0455. PMID: 37010830; PMCID: PMC10071399.



7: Damestani NL, Jacoby J, Yadav SM, Lovely AE, Michael A, Terpstra M, Eshghi M, Rashid B, Cruchaga C, Salat DH, Juttukonda MR. Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults. Neuroimage. 2023 Jul 15;275:120167. doi: 10.1016/j.neuroimage.2023.120167. Epub 2023 May 13. PMID: 37187365.



8: Diers K, Baumeister H, Jessen F, Düzel E, Berron D, Reuter M. An automated, geometry-based method for hippocampal shape and thickness analysis. Neuroimage. 2023 May 24;276:120182. doi: 10.1016/j.neuroimage.2023.120182. Epub ahead of print. PMID: 37230208.



9: Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT. Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART. Alzheimers Dement. 2023 May;19(5):2182-2196. doi: 10.1002/alz.12937. Epub 2023 Jan 15. PMID: 36642985; PMCID: PMC10182252.



10: Eldaief MC, Brickhouse M, Katsumi Y, Rosen H, Carvalho N, Touroutoglou A, Dickerson BC. Atrophy in behavioural variant frontotemporal dementia spans multiple large-scale prefrontal and temporal networks. Brain. 2023 May 18:awad167. doi: 10.1093/brain/awad167. Epub ahead of print. PMID: 37201288.



11: Elliott ML, Hanford LC, Hamadeh A, Hilbert T, Kober T, Dickerson BC, Mair RW, Eldaief MC, Buckner RL. Brain morphometry in older adults with and without dementia using extremely rapid structural scans. Neuroimage. 2023 May 16;276:120173. doi: 10.1016/j.neuroimage.2023.120173. Epub ahead of print. PMID: 37201641.



12: Garzone D, Finger RP, Mauschitz MM, Koch A, Reuter M, Breteler MMB, Aziz NA. Visual impairment and retinal and brain neurodegeneration: A population-based study. Hum Brain Mapp. 2023 May;44(7):2701-2711. doi: 10.1002/hbm.26237. Epub 2023 Feb 28. PMID: 36852616; PMCID: PMC10089094.



13: Hammers DB, Nemes S, Diedrich T, Eloyan A, Kirby K, Aisen P, Kramer J, Nudelman K, Foroud T, Rumbaugh M, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Weintraub S, Wingo TS, Wolk DA, Wong B, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG; LEADS Consortium. Learning slopes in early-onset Alzheimer's disease. Alzheimers Dement. 2023 May 27. doi: 10.1002/alz.13159. Epub ahead of print. PMID: 37243937.



14: Hammers DB, Eloyan A, Taurone A, Thangarajah M, Beckett L, Gao S, Kirby K, Aisen P, Dage JL, Foroud T, Griffin P, Grinberg LT, Jack CR Jr, Kramer J, Koeppe R, Kukull WA, Mundada NS, La Joie R, Soleimani-Meigooni DN, Iaccarino L, Murray ME, Nudelman K, Polsinelli AJ, Rumbaugh M, Toga A, Touroutoglou A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez MF, Womack K, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo TS, Wolk DA, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG; LEADS Consortium. Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection. Alzheimers Dement. 2023 May 31. doi: 10.1002/alz.13160. Epub ahead of print. PMID: 37256497.



15: Haver HL, Ambinder EB, Bahl M, Oluyemi ET, Jeudy J, Yi PH. Appropriateness of Breast Cancer Prevention and Screening Recommendations Provided by ChatGPT. Radiology. 2023 May;307(4):e230424. doi: 10.1148/radiol.230424. Epub 2023 Apr 4. PMID: 37014239.



16: Izquierdo-Garcia D, Désogère P, Fur ML, Shuvaev S, Zhou IY, Ramsay I, Lanuti M, Catalano OA, Catana C, Caravan P, Montesi SB. Biodistribution, Dosimetry, and Pharmacokinetics of 68Ga-CBP8: A Type I Collagen-Targeted PET Probe. J Nucl Med. 2023 May;64(5):775-781. doi: 10.2967/jnumed.122.264530. Epub 2022 Dec 8. PMID: 37116909; PMCID: PMC10152126.



17: Jose O, Stoeckl EM, Miles RC, Mango VL, Reid NJ, Wagner ASB, Weissman IA, Flores EJ, Morla A, Narayan AK. The Impact of Extreme Neighborhood Socioeconomic Deprivation on Access to American College of Radiology-accredited Advanced Imaging Facilities. Radiology. 2023 May;307(3):e222182. doi: 10.1148/radiol.222182. Epub 2023 Mar 14. PMID: 36916894; PMCID: PMC10140634.



18: Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay EZ, Robert SM, Kiziltug E, Damisah EC, Nelson-Williams C, Zhu G, Kong W, Huang AY, Stronge E, Phillips HW, Chhouk BH, Bizzotto S, Chen MH, Adikari TN, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer IE, Berkovic SF, Haider S, Hildebrand MS, Yang E, Gunel M, Lifton RP, Richardson RM, Blümcke I, Alexandrescu S, Huttner A, Heinzen EL, Zhu J, Poduri A, DeLanerolle N, Spencer DD, Lee EA, Walsh CA, Kahle KT. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurol. 2023 May 1:e230473. doi: 10.1001/jamaneurol.2023.0473. Epub ahead of print. PMID: 37126322; PMCID: PMC10152377.



19: Levitt JJ, Zhang F, Vangel M, Nestor PG, Rathi Y, Cetin-Karayumak S, Kubicki M, Coleman MJ, Lewandowski KE, Holt DJ, Keshavan M, Bouix S, Öngür D, Breier A, Shenton ME, O'Donnell LJ. The organization of frontostriatal brain wiring in non-affective early psychosis compared with healthy subjects using a novel diffusion imaging fiber cluster analysis. Mol Psychiatry. 2023 May 12. doi: 10.1038/s41380-023-02031-0. Epub ahead of print. PMID: 37173451.



20: Liao C, Yarach U, Cao X, Iyer SS, Wang N, Kim TH, Tian Q, Bilgic B, Kerr AB, Setsompop K. High-fidelity mesoscale in-vivo diffusion MRI through gSlider-BUDA and circular EPI with S-LORAKS reconstruction. Neuroimage. 2023 Jul 15;275:120168. doi: 10.1016/j.neuroimage.2023.120168. Epub 2023 May 13. PMID: 37187364.



21: Li C, Hong Y, Yang X, Zeng X, Ocepek-Welikson K, Eimicke JP, Kong J, Sano M, Zhu C, Neugroschl J, Aloysi A, Cai D, Martin J, Loizos M, Sewell M, Akrivos J, Evans K, Sheppard F, Greenberg J, Ardolino A, Teresi JA. The use of subjective cognitive complaints for detecting mild cognitive impairment in older adults across cultural and linguistic groups: A comparison of the Cognitive Function Instrument to the Montreal Cognitive Assessment. Alzheimers Dement. 2023 May;19(5):1764-1774. doi: 10.1002/alz.12804. Epub 2022 Oct 12. PMID: 36222321; PMCID: PMC10090224.



22: Li Z, Fan Q, Bilgic B, Wang G, Wu W, Polimeni JR, Miller KL, Huang SY, Tian Q. Diffusion MRI data analysis assisted by deep learning synthesized anatomical images (DeepAnat). Med Image Anal. 2023 May;86:102744. doi: 10.1016/j.media.2023.102744. Epub 2023 Jan 19. PMID: 36867912.



23: Lucas A, Mouchtaris S, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Gugger JJ, Das S, Stein JM, Davis KA. Subcortical functional connectivity gradients in temporal lobe epilepsy. Neuroimage Clin. 2023 May 5;38:103418. doi: 10.1016/j.nicl.2023.103418. Epub ahead of print. PMID: 37187042; PMCID: PMC10196948.



24: Lu J, Liang F, Bai P, Liu C, Xu M, Sun Z, Tian W, Dong Y, Zhang Y, Quan Q, Khatri A, Shen Y, Marcantonio E, Crosby G, Culley DJ, Wang C, Yang G, Xie Z. Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice. Alzheimers Dement. 2023 May 30. doi: 10.1002/alz.13118. Epub ahead of print. PMID: 37249148.



25: Ma T, Wang AQ, Dalca AV, Sabuncu MR. Hyper-convolutions via implicit kernels for medical image analysis. Med Image Anal. 2023 May;86:102796. doi: 10.1016/j.media.2023.102796. Epub 2023 Mar 16. PMID: 36948069.



26: Negnevitsky V, Vives-Gilabert Y, Algarín JM, Craven-Brightman L, Pellicer- Guridi R, O'Reilly T, Stockmann JP, Webb A, Alonso J, Menküc B. MaRCoS, an open- source electronic control system for low-field MRI. J Magn Reson. 2023 May;350:107424. doi: 10.1016/j.jmr.2023.107424. Epub 2023 Mar 21. PMID: 37001194.



27: O'Shea A. Imaging Intestinal Fibrosis with 68Ga-FAPI PET/MRE: A Promising Tool for the Assessment of Crohn Disease Strictures? Radiology. 2023 May;307(3):e230130. doi: 10.1148/radiol.230130. Epub 2023 Feb 28. PMID: 36853184.



28: Pickhardt PJ, Summers RM, Garrett JW, Krishnaraj A, Agarwal S, Dreyer KJ, Nicola GN. Opportunistic Screening: Radiology Scientific Expert Panel. Radiology. 2023 May 23:222044. doi: 10.1148/radiol.222044. Epub ahead of print. PMID: 37219444.



29: Pollak C, Kügler D, Breteler MMB, Reuter M. Quantifying MR head motion in the Rhineland Study - A robust method for population cohorts. Neuroimage. 2023 Jul 15;275:120176. doi: 10.1016/j.neuroimage.2023.120176. Epub 2023 May 18. PMID: 37209757.



30: Rashid B, Glasser MF, Nichols T, Van Essen D, Juttukonda MR, Schwab NA, Greve DN, Yacoub E, Lovely A, Terpstra M, Harms MP, Bookheimer SY, Ances BM, Salat DH, Arnold SE. Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study. Neuroimage. 2023 May 27;276:120192. doi: 10.1016/j.neuroimage.2023.120192. Epub ahead of print. PMID: 37247763.



31: Saffari A, Kellner M, Jordan C, Rosengarten H, Mo A, Zhang B, Strelko O, Neuser S, Davis MY, Yoshikura N, Futamura N, Takeuchi T, Nabatame S, Ishiura H, Tsuji S, Aldeen HS, Cali E, Rocca C, Houlden H, Efthymiou S, Assmann B, Yoon G, Trombetta BA, Kivisäkk P, Eichler F, Nan H, Takiyama Y, Tessa A, Santorelli FM, Sahin M, Blackstone C, Yang E, Schüle R, Ebrahimi-Fakhari D. The clinical and molecular spectrum of ZFYVE26-associated hereditary spastic paraplegia: SPG15. Brain. 2023 May 2;146(5):2003-2015. doi: 10.1093/brain/awac391. PMID: 36315648.



32: Sherrid MV, Bernard S, Tripathi N, Patel Y, Modi V, Axel L, Talebi S, Ghoshhajra BB, Sanborn DY, Saric M, Adlestein E, Alvarez IC, Xia Y, Swistel DG, Massera D, Fifer MA, Kim B. Apical Aneurysms and Mid-Left Ventricular Obstruction in Hypertrophic Cardiomyopathy. JACC Cardiovasc Imaging. 2023 May;16(5):591-605. doi: 10.1016/j.jcmg.2022.11.013. Epub 2023 Jan 11. PMID: 36681586.



33: Wolk DA, Rabinovici GD, Dickerson BC. A Step Forward in the Fight Against Dementia-Are We There Yet? JAMA Neurol. 2023 May 1;80(5):429-430. doi: 10.1001/jamaneurol.2023.0123. PMID: 36912845.



34: Yoon JH, Strand F, Baltzer PAT, Conant EF, Gilbert FJ, Lehman CD, Morris EA, Mullen LA, Nishikawa RM, Sharma N, Vejborg I, Moy L, Mann RM. Standalone AI for Breast Cancer Detection at Screening Digital Mammography and Digital Breast Tomosynthesis: A Systematic Review and Meta-Analysis. Radiology. 2023 May 23:222639. doi: 10.1148/radiol.222639. Epub ahead of print. PMID: 37219445.



35: Zaripova K, Cosmo L, Kazi A, Ahmadi SA, Bronstein MM, Navab N. Graph-in- Graph (GiG): Learning interpretable latent graphs in non-Euclidean domain for biological and healthcare applications. Med Image Anal. 2023 May 13;88:102839. doi: 10.1016/j.media.2023.102839. Epub ahead of print. PMID: 37263109.