Scan Times

An MGH Radiology Research Newsletter

July 2023

Bruce Rosen, Vice-Chair for Research

Daily Statin Medication Reduces Risk of Major Cardiovascular Events by More Than One-Third in People Living with HIV

The department's Michael T. Lu, MD, MPH, and colleagues have reported the primary results from REPRIEVE, a randomized controlled trial (RCT) of pitavastatin to prevent major adverse cardiovascular events (MACE, myocardial infarction and stroke) in people with HIV. The results were published this week in the New England Journal of Medicine.

The trial randomized 7,769 participants from 12 countries to pitavastatin or placebo. The primary result is that the pitavastatin arm had 35% lower risk of MACE than placebo over median 5 years of follow-up. The researchers anticipate that REPRIEVE will change prevention guidelines and improve the care of millions of people with HIV.

REPRIEVE is the work of a multidisciplinary team at MGB and around the world. Trial co-PIs are Dr. Lu (co-director of the Cardiovascular Imaging Research Center, Mass General Department of Radiology), Steve Grinspoon, MD (chief of the MGH Metabolism Unit), Pamela Douglas, MD (Duke University), and Heather Ribaudo, PhD (Harvard T.H. Chan School of Public Health).

Read more in this MGH press release.

Op-Ed: Congress Can Eradicate Hepatitis C and Reduce the Deficit at the Same Time

Jagpreet Chhatwal, PhD, director of the Institute for Technology Assessment in the Mass General Department of Radiology, co-authored a Stat News Op-Ed about the Biden administration's proposed initiative to eliminate hepatitis C in the US. He and colleagues have estimated that the initiative will avert 20,000 cases of cancer, 49,100 cases of diabetes, and 25,000 cases of chronic kidney disease over a decade. It will save 24,000 lives.

Read the Op-Ed here.

Bruce Rosen on the Advanced Imaging Technologies Coming to the Martinos Center

In this video, Dr. Rosen describes several cutting-edge technologies that will advance research in the center and elsewhere in the coming years: the "Connectome 2.0" MRI scanner recently installed in the center, a PET insert for the center's ultrahigh-field (7T) MRI scanner, the first human-scale magnetic particle imaging (MPI) device, and the portable "FlexNIRS" optical imaging technology for a variety of applications.

Watch the video here.

Intimate Partner Violence Can Cause Brain Injury -- But There's Still Hope

Eve Valera, PhD, a researchers in the MGH Department of Psychiatry and an affiliated faculty member in the Martinos Center, discusses her work with brain injury in people who have experienced intimate partner violence (IPV) -- and emphasizes the importance of recognizing when such injury might have occurred.

Watch the video here.

Select Papers from June 2023

1: Bahl M, Do S. Artificial Intelligence Applied to Contrast-enhanced Mammography: Exploring Uncharted Territory. Radiology. 2023 Jun;307(5):e231140. doi: 10.1148/radiol.231140. PMID: 37338358; PMCID: PMC10315514.

2: Fischbach L, Bauer T, Diers K, Witt JA, Brugues M, Borger V, Schidlowski M, Rácz A, Baumgartner T, von Wrede R, Paech D, Weber B, Radbruch A, Vatter H, Becker AJ, Huppertz HJ, Helmstaedter C, Surges R, Reuter M, Rüber T. A novel geometry-based analysis of hippocampal morphometry in mesial temporal lobe epilepsy. Hum Brain Mapp. 2023 Aug 15;44(12):4467-4479. doi: 10.1002/hbm.26392. Epub 2023 Jun 22. PMID: 37347650; PMCID: PMC10365234.

3: Griffin P, Apostolova L, Dickerson BC, Rabinovici G, Salloway S, Brandt K, Masdeu J, Hammers D, Raghuram S, Hall S, Carrillo MC. Developments in understanding early onset Alzheimer's disease. Alzheimers Dement. 2023 Jun 30. doi: 10.1002/alz.13353. Epub ahead of print. PMID: 37390354.

4: Guehl NJ, Dhaynaut M, Hanseeuw BJ, Moon SH, Lois C, Thibault E, Fu JF, Price JC, Johnson KA, El Fakhri G, Normandin MD. Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging. J Nucl Med. 2023 Jun;64(6):968-975. doi: 10.2967/jnumed.122.265072. Epub 2023 Mar 30. PMID: 36997330; PMCID: PMC10241011.

5: Holzschuh JC, Mix M, Ruf J, Hölscher T, Kotzerke J, Vrachimis A, Doolan P, Ilhan H, Marinescu IM, Spohn SKB, Fechter T, Kuhn D, Bronsert P, Gratzke C, Grosu R, Kamran SC, Heidari P, Ng TSC, Könik A, Grosu AL, Zamboglou C. Deep Learning based Automated Delineation of the Intraprostatic Gross Tumour Volume in PSMA-PET for Patients with Primary Prostate Cancer. Radiother Oncol. 2023 Jun 30:109774. doi: 10.1016/j.radonc.2023.109774. Epub ahead of print. PMID: 37394103.

6: Hong CW, Chernyak V, Choi JY, Lee S, Potu C, Delgado T, Wolfson T, Gamst A, Birnbaum J, Kampalath R, Lall C, Lee JT, Owen JW, Aguirre DA, Mendiratta-Lala M, Davenport MS, Masch W, Roudenko A, Lewis SC, Kierans AS, Hecht EM, Bashir MR, Brancatelli G, Douek ML, Ohliger MA, Tang A, Cerny M, Fung A, Costa EA, Corwin MT, McGahan JP, Kalb B, Elsayes KM, Surabhi VR, Blair K, Marks RM, Horvat N, Best S, Ash R, Ganesan K, Kagay CR, Kambadakone A, Wang J, Cruite I, Bijan B, Goodwin M, Moura Cunha G, Tamayo-Murillo D, Fowler KJ, Sirlin CB. A Multicenter Assessment of Interreader Reliability of LI-RADS Version 2018 for MRI and CT. Radiology. 2023 Jun;307(5):e222855. doi: 10.1148/radiol.222855. Erratum in: Radiology. 2023 Jul;308(1):e239018. PMID: 37367445; PMCID: PMC10315518.

7: Huber FA, Singhal V, Tuli S, Becetti I, López López AP, Bouxsein ML, Misra M, Bredella MA. Two-year Skeletal Effects of Sleeve Gastrectomy in Adolescents with Obesity Assessed with Quantitative CT and MR Spectroscopy. Radiology. 2023 Jun;307(5):e223256. doi: 10.1148/radiol.223256. PMID: 37310246; PMCID: PMC10315522.

8: Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay EZ, Robert SM, Kiziltug E, Damisah EC, Nelson-Williams C, Zhu G, Kong W, Huang AY, Stronge E, Phillips HW, Chhouk BH, Bizzotto S, Chen MH, Adikari TN, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer IE, Berkovic SF, Haider S, Hildebrand MS, Yang E, Gunel M, Lifton RP, Richardson RM, Blümcke I, Alexandrescu S, Huttner A, Heinzen EL, Zhu J, Poduri A, DeLanerolle N, Spencer DD, Lee EA, Walsh CA, Kahle KT. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurol. 2023 Jun 1;80(6):578-587. doi: 10.1001/jamaneurol.2023.0473. PMID: 37126322; PMCID: PMC10152377.

9: Kong R, Tan YR, Wulan N, Ooi LQR, Farahibozorg SR, Harrison S, Bijsterbosch JD, Bernhardt BC, Eickhoff S, Thomas Yeo BT. Comparison between gradients and parcellations for functional connectivity prediction of behavior. Neuroimage. 2023 Jun;273:120044. doi: 10.1016/j.neuroimage.2023.120044. Epub 2023 Mar 20. PMID: 36940760; PMCID: PMC10192836.

10: Levitt J, Yang Z, Williams SD, Lütschg Espinosa SE, Garcia-Casal A, Lewis LD. EEG-LLAMAS: A low-latency neurofeedback platform for artifact reduction in EEG-fMRI. Neuroimage. 2023 Jun;273:120092. doi: 10.1016/j.neuroimage.2023.120092. Epub 2023 Apr 5. PMID: 37028736; PMCID: PMC10202030.

11: Morais A, Qin T, Ayata C, Harriott AM. Inhibition of persistent sodium current reduces spreading depression-evoked allodynia in a mouse model of migraine with aura. Pain. 2023 Jun 6. doi: 10.1097/j.pain.0000000000002962. Epub ahead of print. PMID: 37318029.

12: Ortega-Cruz D, Iglesias JE, Rabano A, Strange BA. Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior. Alzheimers Dement. 2023 Jun 27. doi: 10.1002/alz.13352. Epub ahead of print. PMID: 37366342.

13: Peters GW, Tarbell NJ. Dr A's Dilemma. Int J Radiat Oncol Biol Phys. 2023 Jun 1;116(2):214. doi: 10.1016/j.ijrobp.2023.02.035. PMID: 37179083.

14: Pickhardt PJ, Summers RM, Garrett JW, Krishnaraj A, Agarwal S, Dreyer KJ, Nicola GN. Opportunistic Screening: Radiology Scientific Expert Panel. Radiology. 2023 Jun;307(5):e222044. doi: 10.1148/radiol.222044. Epub 2023 May 23. PMID: 37219444; PMCID: PMC10315516.

15: Polsinelli AJ, Wonderlin RJ, Hammers DB, Garcia AP, Eloyan A, Taurone A, Thangarajah M, Beckett L, Gao S, Wang S, Kirby K, Logan PE, Aisen P, Dage JL, Foroud T, Griffin P, Iaccarino L, Kramer JH, Koeppe R, Kukull WA, La Joie R, Mundada NS, Murray ME, Nudelman K, Soleimani-Meigooni DN, Rumbaugh M, Toga AW, Touroutoglou A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez MF, Womack K, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo TS, Wolk DA, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG; LEADS Consortium. Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort. Alzheimers Dement. 2023 Jun 9. doi: 10.1002/alz.13344. Epub ahead of print. PMID: 37296082.

16: Prakken NHJ, Besson FL, Borra RJH, Büther F, Buechel RR, Catana C, Chiti A, Dierckx RAJO, Dweck MR, Erba PA, Glaudemans AWJM, Gormsen LC, Hristova I, Koole M, Kwee TC, Mottaghy FM, Polycarpou I, Prokop M, Stegger L, Tsoumpas C, Slart RHJA. PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL). Eur J Nucl Med Mol Imaging. 2023 Jun 28. doi: 10.1007/s00259-023-06308-y. Epub ahead of print. PMID: 37378857.

17: Sandström A, Ellerbrock I, Tour J, Kadetoff D, Jensen K, Kosek E. Dysfunctional Activation of the Dorsolateral Prefrontal Cortex During Pain Anticipation Is Associated With Altered Subsequent Pain Experience in Fibromyalgia Patients. J Pain. 2023 Jun 21:S1526-5900(23)00415-7. doi: 10.1016/j.jpain.2023.05.006. Epub ahead of print. PMID: 37354157.

18: Wu D, Schaper FLWVJ, Jin G, Qi L, Du J, Wang X, Wang Y, Xu C, Wang X, Yu T, Fox MD, Ren L. Human anterior thalamic stimulation evoked cortical potentials align with intrinsic functional connectivity. Neuroimage. 2023 Aug 15;277:120243. doi: 10.1016/j.neuroimage.2023.120243. Epub 2023 Jun 21. PMID: 37353098.

19: Yang K, Li X, Yu L, Li B, Marschall TA, Liu B. Visualization and comparison of CT dose distribution between axial and helical acquisitions. Med Phys. 2023 Jun 7. doi: 10.1002/mp.16530. Epub ahead of print. PMID: 37283112.

20: Yan X, Kong R, Xue A, Yang Q, Orban C, An L, Holmes AJ, Qian X, Chen J, Zuo XN, Zhou JH, Fortier MV, Tan AP, Gluckman P, Chong YS, Meaney MJ, Bzdok D, Eickhoff SB, Yeo BTT. Homotopic local-global parcellation of the human cerebral cortex from resting-state functional connectivity. Neuroimage. 2023 Jun;273:120010. doi: 10.1016/j.neuroimage.2023.120010. Epub 2023 Mar 12. PMID: 36918136; PMCID: PMC10212507.

21: Yoon JH, Strand F, Baltzer PAT, Conant EF, Gilbert FJ, Lehman CD, Morris EA, Mullen LA, Nishikawa RM, Sharma N, Vejborg I, Moy L, Mann RM. Standalone AI for Breast Cancer Detection at Screening Digital Mammography and Digital Breast Tomosynthesis: A Systematic Review and Meta-Analysis. Radiology. 2023 Jun;307(5):e222639. doi: 10.1148/radiol.222639. Epub 2023 May 23. PMID: 37219445; PMCID: PMC10315526.