December 2019 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and funding updates from the prior month. In November there were: 27 papers led by Brigham researchers published in top-tier journals 3 research briefs 6 press releases 9 tweets about new research 24 awards and $5,036,682 awarded in new grants

Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney Impairment. Bajaj NS, Singh A, Zhou W, Gupta A, Fujikura K, [et al.], Di Carli MF. Circulation . 2019 Nov 29. doi: 10.1161/CIRCULATIONAHA.119.043916.

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Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Subramanian A, Sidhom EH, Emani M, Vernon K, Sahakian N, [et al.] Greka A. Nat Commun. 2019 Nov 29;10(1):5462. doi: 10.1038/s41467-019-13382-0.

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Platelet alloantibody detection: moving ahead. Wilkie AR, Italiano JE. Blood . 2019 Nov 28;134(22):1887-1888. doi: 10.1182/ blood .2019003434.

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Comparison of Events Across Bleeding Scales in the ENGAGE AF-TIMI 48 Trial. Bergmark BA, Kamphuisen PW, Wiviott SD, Ruff CT, Antman EM, [et al.] Giugliano RP. Circulation . 2019 Nov 26;140(22):1792-1801. doi: 10.1161/CIRCULATIONAHA.119.041346.

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Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons. Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. Nat Commun. 2019 Nov 26;10(1):5372. doi: 10.1038/s41467-019-13029-0.

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Artificial intelligence for global health. Hosny A, Aerts HJWL. Science . 2019 Nov 22;366(6468):955-956. doi: 10.1126/science.aay5189. No abstract available.

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CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer . Hwang JH, Seo JH, Beshiri ML, Wankowicz S, Liu D, [et al.] Hahn WC. Cell  Rep. 2019 Nov 19;29(8):2355-2370.e6. doi: 10.1016/j.celrep.2019.10.068.

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Detecting Edema and Fibrosis in Myocarditis: Not as Easy as It Looks. Blankstein R. J Am Coll Cardiol . 2019 Nov 19;74(20):2449-2451. doi: 10.1016/j.jacc.2019.10.008.

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C-reactive protein is associated with cognitive performance in a large cohort of euthymic patients with bipolar disorder. Millett CE, Perez-Rodriguez M, Shanahan M, Larsen E, Yamamoto HS, [et al.] Burdick KE. Mol Psychiatry. 2019 Nov 19. doi: 10.1038/s41380-019-0591-1

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Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure. Solomon SD, Vaduganathan M, Claggett BL, Packer M, Zile M, [et al.] McMurray JJV. Circulation . 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044586

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Effects of Sacubitril-Valsartan, versus Valsartan, in Women Compared to Men with Heart Failure and Preserved Ejection Fraction: Insights from PARAGON-HF. McMurray JJV, Jackson AM, Lam CSP, Redfield MM, Anand IS, [et al.] Solomon SD. Circulation . 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044491.

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A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation. Ghazizadeh Z, Kiviniemi TO, Olafsson S, Plotnick D, Beerens M, [et al.] MacRae CA. Circulation . 2019 Nov 16. doi: 10.1161/CIRCULATIONAHA.119.044268.

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Megakaryocyte Reprogramming in Breast Cancer. Roweth HG, Malloy M, Goreczny G, Johnson KE, McAllister SS, [et al.] Battinelli E. Blood . 2019 Nov 13;134(Supplement_1):12. doi: 10.1182/ blood -2019-124894.

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Coronary Microvascular Dysfunction in Vasospastic Angina: Provocative Role for the Microcirculation in Macrovessel Disease Prognosis. Taqueti VR. J Am Coll Cardiol. 2019 Nov 12;74(19):2361-2364. doi: 10.1016/j.jacc.2019.09.042 .

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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, [et al.] Redline S. Nat Commun. 2019 Nov 12;10(1):5121. doi: 10.1038/s41467-019-12958-0.

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Supplementation with Vitamin D and/or Omega-3 Fatty Acids and Incidence of Heart Failure Hospitalization: VITAL-Heart Failure. Djoussé L, Cook NR, Kim E, Bodar V, Walter J, [et al.] VITAL Research Group. Circulation . 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044645.

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Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial. Marston NA, Kamanu FK, Nordio F, Gurmu Y, Roselli C, [et al.] Ruff CT. Circulation . 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.043805.

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Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells via p53-Induced Quiescence. Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, [et al.] Lee RT. Circulation . 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044205.

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REDUCE-IT USA: Results from the 3,146 Patients Randomized in the United States. Bhatt DL, Miller M, Brinton EA, Jacobson TA, Steg PG, [et al.] REDUCE-IT Investigators. Circulation . 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044440.

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Evaluating the Effects of Canagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Chronic Kidney Disease According to Baseline HbA1c, Including Those with HbA1c <7%: Results From the CREDENCE Trial. Cannon CP, Perkovic V, Agarwal R, Baldassarre J, Bakris G, [et al.] Mahaffey KW. Circulation . 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044359

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Prior Heart Failure Hospitalization, Clinical Outcomes, and Response to Sacubitril/Valsartan Compared with Valsartan in HFpEF. Vaduganathan M, Claggett BL, Desai AS, Anker SD, Perrone SV, [et al.] Solomon SD. J Am Coll Cardiol . 2019 Nov 6. pii: S0735-1097(19)38299-3. doi: 10.1016/j.jacc.2019.11.003.

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Heart Failure Risk Stratification and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes Mellitus. Berg DD, Wiviott SD, Scirica BM, Gurmu Y, Mosenzon O, [et al.] Sabatine MS. Circulation . 2019 Nov 5;140(19):1569-1577. doi: 10.1161/CIRCULATIONAHA.119.042685

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Advanced Heart Failure Therapies for Adults With Congenital Heart Disease: JACC State-of-the-Art Review. Givertz MM, DeFilippis EM, Landzberg MJ, Pinney SP, Woods RK, Valente AM. J Am Coll Cardiol. 2019 Nov 5;74(18):2295-2312. doi: 10.1016/j.jacc.2019.09.004. Review.

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Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression. Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, [et al.] Turner JR. Gastroenterology . 2019 Nov;157(5):1323-1337. doi: 10.1053/j.gastro.2019.07.058.

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Author Correction: Subsets of exhausted CD8 +  T cells differentially mediate tumor control and respond to checkpoint blockade. Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, [et al.] Haining WN. Nat Immunol. 2019 Nov;20(11):1556. doi: 10.1038/s41590-019-0528-5.

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SGLT-2 inhibitors in heart failure: a new therapeutic avenue. Vaduganathan M, Butler J. Nat Med. 2019 Nov;25(11):1653-1654. doi: 10.1038/s41591-019-0647-4

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Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Mina MJ, Kula T, Leng Y, Li M, de Vries RD, [et al.] Elledge SJ. Science . 2019 Nov 1;366(6465):599-606. doi: 10.1126/science.aay6485.

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