May 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and funding updates from the prior month.

In April there were: 33 papers led by Brigham researchers published in top-tier journals 17 tweets about new research 52 awards with $42,892,298 in new grants

Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer. Agnelli G, Becattini C, Meyer G, Muñoz A, Huisman MV, [et al.] Verso M; Caravaggio Investigators. N Engl J Med . 2020 Apr 23;382(17):1599-1607. doi: 10.1056/NEJMoa1915103. Epub 2020 Mar 29.PMID: 32223112

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MYC Controls the Epstein-Barr Virus Lytic Switch. Guo R, Jiang C, Zhang Y, Govande A, Trudeau SJ, [et. al] Gewurz BE Mol Cell . 2020 Apr 3:S1097-2765(20)30193-3. doi: 10.1016/j.molcel.2020.03.025. Online ahead of print.PMID: 32315601

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Web Exclusive. Annals On Call - COVID-19: Is Chloroquine the Answer? Centor RM, Kim AH, Sparks JA. Ann Intern Med . 2020 May 5;172(9):OC1. doi: 10.7326/A20-0003. Epub 2020 Apr 9.PMID: 32271869

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Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon SD. N Engl J Med . 2020 Apr 23;382(17):1653-1659. doi: 10.1056/NEJMsr2005760. Epub 2020 Mar 30.PMID: 32227760

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Mechanisms and therapeutic implications of hypermutation in gliomas. Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, [et. al] Ligon KL. Nature . 2020 Apr;580(7804):517-523. doi: 10.1038/s41586-020-2209-9. Epub 2020 Apr 15.PMID: 32322066

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Diagnosis and Management of Obstructive Sleep Apnea: A Review. Gottlieb DJ, Punjabi NM. JAMA . 2020 Apr 14;323(14):1389-1400. doi: 10.1001/jama.2020.3514.PMID: 32286648 Review.

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Initial Invasive or Conservative Strategy for Stable Coronary Disease. Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, [et. al] Rosenberg Y; ISCHEMIA Research Group. N Engl J Med . 2020 Apr 9;382(15):1395-1407. doi: 10.1056/NEJMoa1915922. Epub 2020 Mar 30.PMID: 32227755 Clinical Trial.

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A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling. Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB. Cell  Rep. 2020 Apr 7;31(1):107466. doi: 10.1016/j.celrep.2020.03.030.PMID: 32268091

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Drug Evaluation during the Covid-19 Pandemic. Rome BN, Avorn J. N Engl J Med . 2020 Apr 14. doi: 10.1056/NEJMp2009457. Online ahead of print.PMID: 32289216

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In vitro characterization of the human segmentation clock. Diaz-Cuadros M, Wagner DE, Budjan C, Hubaud A, Tarazona OA, [et. al] Pourquié O. Nature . 2020 Apr;580(7801):113-118. doi: 10.1038/s41586-019-1885-9. Epub 2020 Jan 8.PMID: 31915384

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Effectiveness and Safety of Apixaban Compared With Rivaroxaban for Patients With Atrial Fibrillation in Routine Practice: A Cohort Study. Fralick M, Colacci M, Schneeweiss S, Huybrechts KF, Lin KJ, Gagne JJ. Ann Intern Med . 2020 Apr 7;172(7):463-473. doi: 10.7326/M19-2522. Epub 2020 Mar 10.PMID: 32150751

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Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, [et. al] DeCaprio JA. Nat Cell Biol . 2020 May;22(5):603-615. doi: 10.1038/s41556-020-0503-2. Epub 2020 Apr 13.PMID: 32284543

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Most Patients Undergoing Ground And Air Ambulance Transportation Receive Sizable Out-Of-Network Bills. Chhabra KR, McGuire K, Sheetz KH, Scott JW, Nuliyalu U, Ryan AM. Health Aff  (Millwood). 2020 May;39(5):777-782. doi: 10.1377/hlthaff.2019.01484. Epub 2020 Apr 15.PMID: 32293925

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Effects of Interleukin-1β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial. Vallurupalli M, MacFadyen JG, Glynn RJ, Thuren T, Libby P, Berliner N, Ridker PM. Ann Intern Med . 2020 Apr 21;172(8):523-532. doi: 10.7326/M19-2945. Epub 2020 Mar 24.PMID: 32203978

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Reconsidering Prostate Cancer Mortality - The Future of PSA Screening. Welch HG, Albertsen PC. N Engl J Med . 2020 Apr 16;382(16):1557-1563. doi: 10.1056/NEJMms1914228.PMID: 32294352

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Managing Stable Ischemic Heart Disease. Antman EM, Braunwald E. N Engl J Med . 2020 Apr 9;382(15):1468-1470. doi: 10.1056/NEJMe2000239. Epub 2020 Mar 30.PMID: 32227752

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How to Obtain a Nasopharyngeal Swab Specimen. Marty FM, Chen K, Verrill KA. N Engl J Med . 2020 Apr 17. doi: 10.1056/NEJMvcm2010260. Online ahead of print.PMID: 32302471

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Waiting. Rourke EJ. N Engl J Med . 2020 Apr 13. doi: 10.1056/NEJMp2007073. Online ahead of print.PMID: 32283002

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Utility, Appropriateness, and Content of Electronic Consultations Across Medical Subspecialties. Ahmed S, Kelly YP, Behera TR, Zelen MH, Kuye I, [et. al] Mendu ML. Ann Intern Med . 2020 May 19;172(10):641-647. doi: 10.7326/M19-3852. Epub 2020 Apr 14.PMID: 32283548

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Missing the Target. Iriarte C, Vaitkevicius H, Marty FM, Miller AL, Loscalzo J. N Engl J Med . 2020 Apr 2;382(14):1353-1359. doi: 10.1056/NEJMcps1901669.PMID: 32242362

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Abortion during the Covid-19 Pandemic - Ensuring Access to an Essential Health Service. Bayefsky MJ, Bartz D, Watson KL. N Engl J Med . 2020 May 7;382(19):e47. doi: 10.1056/NEJMp2008006. Epub 2020 Apr 9.PMID: 32272002

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Universal Masking in Hospitals in the Covid-19 Era. Klompas M, Morris CA, Sinclair J, Pearson M, Shenoy ES. N Engl J Med . 2020 May 21;382(21):e63. doi: 10.1056/NEJMp2006372. Epub 2020 Apr 1.PMID: 32237672

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Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism. Lee CAA, Banerjee P, Wilson BJ, Wu S, Guo Q, [et. al] Frank NY. J Biol Chem . 2020 Apr 20:jbc.RA120.013778. doi: 10.1074/jbc.RA120.013778. Online ahead of print.PMID: 32317280

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Medicare Part D and Insulin Affordability - The Devil Is in the Details. Dusetzina SB, Huskamp HA, Keohane LM, Keating NL. N Engl J Med . 2020 May 14;382(20):1878-1880. doi: 10.1056/NEJMp2001649. Epub 2020 Apr 1.PMID: 32237673

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COVID-19 and the coming epidemic in US immigration detention centres. Meyer JP, Franco-Paredes C, Parmar P, Yasin F, Gartland M. Lancet  Infect Dis. 2020 Apr 15:S1473-3099(20)30295-4. doi: 10.1016/S1473-3099(20)30295-4. Online ahead of print.PMID: 32304631

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Kidney Function in Patients With Type 2 Diabetes After Vitamin D Supplementation-Reply. de Boer IH, Zelnick LR, Manson JE. JAMA . 2020 Apr 14;323(14):1411-1412. doi: 10.1001/jama.2020.1400.PMID: 32286641

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Removing the Thyroid From Images, Not From Patients. Welch HG. JAMA  Intern Med. 2020 Apr 20. doi: 10.1001/jamainternmed.2020.0958. Online ahead of print.PMID: 32310249

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Penicillin Allergy. Reply. Castells M, Khan DA, Phillips EJ. N Engl J Med . 2020 Apr 2;382(14):1380. doi: 10.1056/NEJMc2000115.PMID: 32242379

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More on Venous Thrombosis during Spaceflight. Levy JH, Connors JM. N Engl J Med . 2020 Apr 2;382(14):1381. doi: 10.1056/NEJMc2001365.PMID: 32242380

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Trends in Utilization of Prescribed Controlled Substances in US Commercially Insured Adults, 2004-2019. Bykov K, He M, Gagne JJ. JAMA  Intern Med. 2020 Apr 20:e200989. doi: 10.1001/jamainternmed.2020.0989. Online ahead of print.PMID: 32310250

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Addressing Social Determinants of Health: Time for a Polysocial Risk Score. Figueroa JF, Frakt AB, Jha AK. JAMA . 2020 Apr 3. doi: 10.1001/jama.2020.2436. Online ahead of print.PMID: 32242887

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Web Exclusive. Annals On Call - Impact of Estrogens After Hysterectomy. Centor RM, Manson JE. Ann Intern Med . 2020 Apr 21;172(8):OC1. doi: 10.7326/A19-0028.PMID: 32311721

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High-Dose Vitamin D3 for Critically Ill Vitamin D-Deficient Patients. Preiser JC, Christopher K. N Engl J Med . 2020 Apr 23;382(17):1670. doi: 10.1056/NEJMc2000993.PMID: 32320584

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