November 2019 We are excited to present the research community with the third edition of the Science Spotlight new sletter. It features publications from Brigham researchers in high-impact journals and funding updates from the prior month. In October there were: 26 papers led by Brigham researchers published in top-tier journals 4 research briefs 5 press releases 24 tweets about new research 52 awards and $9,097,965 awarded in new grants

The Immune-Mind Connection Hang S, Huh JR. Cell . 2019 Oct 31;179(4):803-805. doi: 10.1016/j.cell.2019.10.012.

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Response by Kato et al to Letter Regarding Article, "Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus". Kato ET, Sabatine MS, Wiviott SD. Circulation . 2019 Oct 29;140(18):e740-e741. doi: 10.1161/CIRCULATIONAHA.119.042848. Epub 2019 Oct 28.

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More CREDENCE for SGLT2 Inhibition. Verma S, Bhatt DL. Circulation . 2019 Oct 29;140(18):1448-1450. doi: 10.1161/CIRCULATIONAHA.119.041181. Epub 2019 Jun 11.

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Dissecting racial bias in an algorithm used to manage the health of populations. Obermeyer Z, Powers B, Vogeli C, Mullainathan S. Science . 2019 Oct 25;366(6464):447-453. doi: 10.1126/ science .aax2342.

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Resolvin D4 attenuates the severity of pathological thrombosis in mice. Cherpokova D, Jouvene CC, Libreros S, DeRoo EP, Chu L, [et al.] Serhan CN. Blood . 2019 Oct 24;134(17):1458-1468. doi: 10.1182/ blood .2018886317.

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Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. Gallagher CS, Mäkinen N, Harris HR, Rahmioglu N, Uimari O, [et al.] Morton CC. Nat Commun. 2019 Oct 24;10(1):4857. doi: 10.1038/s41467-019-12536-4 .

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Resolution metabolomes activated by hypoxic environment. Norris PC, Libreros S, Serhan CN. Sci Adv. 2019 Oct 23;5(10):eaax4895. doi: 10.1126/sciadv.aax4895. eCollection 2019 Oct.

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Time for a Change or Just a Reason to Question Further? Shaw LJ, Min JK, Blankstein R. J Am Coll Cardiol. 2019 Oct 22;74(16):2071-2073. doi: 10.1016/j.jacc.2019.08.1014.

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Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients With Heart Failure and Reduced Ejection Fraction: PARADIGM-HF. Selvaraj S, Claggett B, Pozzi A, McMurray JJV, Jhund PS, [et al.] Solomon SD. Circulation . 2019 Oct 22;140(17):1369-1379. doi: 10.1161/CIRCULATIONAHA.119.039920. Epub 2019 Sep 12

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Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, [et al.] Blumberg RS. Nat Immunol. 2019 Oct 21. doi: 10.1038/s41590-019-0504-0

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Desmopressin and the risk of hyponatremia: A population-based cohort study. Fralick M, Schneeweiss S, Wallis CJD, Jung EH, Kesselheim AS. PLoS Med. 2019 Oct 21;16(10):e1002930. doi: 10.1371/journal.pmed.1002930. eCollection 2019 Oct.

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Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, [et al.] Turley SJ. Nat Immunol. 2019 Oct 21. doi: 10.1038/s41590-019-0515-x.

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PTPN2 regulates the generation of exhausted CD8 +  T cell subpopulations and restrains tumor immunity. LaFleur MW, Nguyen TH, Coxe MA, Miller BC, Yates KB, [et al.] Sharpe AH. Nat Immunol. 2019 Oct;20(10):1335-1347. doi: 10.1038/s41590-019-0480-4.

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Killing Two Birds With One Stone: Complete Percutaneous Approach to Aortic Valve Replacement and Revascularization. Kaneko T. Circulation . 2019 Oct 15;140(16):1306-1307. doi: 10.1161/CIRCULATIONAHA.119.042921. Epub 2019 Oct 14.

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Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials. Marston NA, Giugliano RP, Im K, Silverman MG, O'Donoghue ML, [et al.] Sabatine MS. Circulation . 2019 Oct 15;140(16):1308-1317. doi: 10.1161/CIRCULATIONAHA.119.041998. Epub 2019 Sep 18.

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Trends in Place of Death for Individuals With Cardiovascular Disease in the United States. Cross SH, Kaufman BG, Mentz RJ, Kamal AH, Taylor DH Jr, Warraich HJ. J Am Coll Cardiol . 2019 Oct 15;74(15):1943-1946. doi: 10.1016/j.jacc.2019.08.1015.

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Clinical Utility of Targeted Next-Generation Screening of Peripheral Blood in the Evaluation of Patients with Cytopenias. Shanmugam V, Parnes A, Kalyanaraman R, Morgan EA, Kim AS. Blood . 2019 Oct 10. pii: blood.2019001610. doi: 10.1182/blood.2019001610. [Epub ahead of print]

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The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4- positive T-cells that are PD-1-negative. Patel SS, Weirather JL, Lipschitz M, Lako A, Chen PH, [et al.] Rodig SJ. Blood . 2019 Oct 10. pii: blood.2019002206. doi: 10.1182/blood.2019002206.

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Comparison of Events Across Bleeding Scales in the ENGAGE AF-TIMI 48 Trial. Bergmark BA, Kamphuisen PW, Wiviott SD, Ruff CT, Antman EM, [et al.] Giugliano RP. Circulation . 2019 Oct 10. doi: 10.1161/CIRCULATIONAHA.119.041346.

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Cardiac Magnetic Resonance Stress Perfusion Imaging for Evaluation of Patients With Chest Pain. Kwong RY, Ge Y, Steel K, Bingham S, Abdullah S, [et al.] Simonetti OP. J Am Coll Cardiol. 2019 Oct 8;74(14):1741-1755. doi: 10.1016/j.jacc.2019.07.074.

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A luminal unfolding microneedle injector for oral delivery of macromolecules. Abramson A, Caffarel-Salvador E, Soares V, Minahan D, Tian RY, [et al.] Traverso G. Nat Med. 2019 Oct 7. doi: 10.1038/s41591-019-0598-9.

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, [et al.] Aguirre AJ. Cell  Rep. 2019 Oct 1;29(1):118-134.e8. doi: 10.1016/j.celrep.2019.08.090.

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The New World Symposium on Pulmonary Hypertension Guidelines: Should Twenty-One Be the New Twenty-Five? Ruopp NF, Farber HW. Circulation . 2019 Oct;140(14):1134-1136. doi: 10.1161/CIRCULATIONAHA.119.040292. Epub 2019 Sep 30.

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Cardiovascular Toxicities of Immune Checkpoint Inhibitors: JACC Review Topic of the Week. Ball S, Ghosh RK, Wongsaengsak S, Bandyopadhyay D, Ghosh GC, [et al.] Bhatt DL. J Am Coll Cardiol. 2019 Oct 1;74(13):1714-1727. doi: 10.1016/j.jacc.2019.07.079. Review.

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Positron Emission Computed Tomography Identified Ischemia to Guide Treatment Strategies in Stable Ischemic Heart Disease. Hachamovitch R, Di Carli MF. J Am Coll Cardiol. 2019 Oct 1;74(13):1655-1657. doi: 10.1016/j.jacc.2019.07.048.

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Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, [et al.] Sage PT. Nat Immunol. 2019 Oct;20(10):1360-1371. doi: 10.1038/s41590-019-0472-4. Epub 2019 Sep 2.

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